Search results

Additive manufacturing (AM), also known as three-dimensional (3D) printing technology, has been used in the health-care industry for over two decades. It is in high demand in the health-care industry due to its strength to manufacture custom-designed and personalized 3D constructs. Recently, AM technologies are being explored to develop personalized drug delivery systems, such as personalized oral dosages, implants and others due to their potential to design and develop systems with complex geometry and programmed controlled release profile. Furthermore, in 2015, the US Food and Drug Administration approved the first AM medication, Spritam® (Apprecia Pharmaceuticals) which has led to tremendous interest in exploring this technology as a bespoke solution for patient-specific drug delivery systems. The purpose of this study is to provide a comprehensive overview of AM technologies applied to the development of personalized drug delivery systems, including an analysis of the commercial status of AM based drugs and delivery devices.

This review paper provides a detailed understanding of how AM technologies are used to develop personalized drug delivery systems. Different AM technologies and how these technologies can be chosen for a specific drug delivery system are discussed. Different types of materials used to manufacture personalized drug delivery systems are also discussed here. Furthermore, recent preclinical and clinical trials are discussed. The challenges and future perceptions of personalized medicine and the clinical use of these systems are also discussed.

Substantial works are ongoing to develop personalized medicine using AM technologies. Understanding the regulatory requirements is needed to establish this area as a point-of-care solution for patients. Furthermore, scientists, engineers and regulatory agencies need to work closely to successfully translate the research efforts to clinics.

This review paper highlights the recent efforts of AM-based technologies in the field of personalized drug delivery systems with an insight into the possible future direction.

The purpose of this study is to look into the hygroscopic and tribo-mechanical properties of a polypropylene/polyamide-6 (PP/PA6) blend and a PP/PA6/Boron sesquioxide composite.

The hygroscopic behaviour of the PP/PA6 blend and PP/PA6/Boron sesquioxide composite was studied using a water contact angle goniometer in this study. To validate the hygroscopic behaviour of the blend and composite, water contact angles and surface energy of the materials were investigated. Tensile strength and hardness tests were used to determine mechanical characteristics, and tribological experiments on a pin-on-disc tribometer were used to demonstrate the friction and wear rates of dry and water-conditioned blends and composites. The melting temperature of dry and water-conditioned composites was determined using DSC analysis.

The hygroscopic effect of the PP/PA6 blend was found to be minimal in the experiment, while it was relatively dominating in the PP/PA6/Boron sesquioxide composite. Tensile strength was found to be somewhat lower in blend and composite compared to virgin PP, whereas hardness was found to be higher in both blend and composite. The composite’s tribological testing findings were fairly outstanding, with the coefficient of friction (COF) and wear rates significantly reduced due to boron sesquioxide reinforcement. The reaction between boron sesquioxide and water molecules produced boric acid, which increased the tribological characteristics of the composite even further. Following 30 days of water conditioning, the weight of the blend increased by 3.64% and the weight of the composite increased by 6.45% as compared to the dry materials. After water conditioning, tensile strength reduced by 0.8% for the blend and 14.16% for the composite. Hardness was determined to be the same in the dry state and after water-conditioning for blend but dropped 1% for composite. As compared to blend, the COF and wear resistance of composite were 15.52% and 25.16% higher, respectively. After absorbing some water, the results increased to 28.57% and 34.9%, respectively.

The mechanical and thermal behaviour of polymer composites (particularly polyamide composites) vary depending on the surrounding environment. Tests were carried out to explore the effect of water treatment on the tribo-mechanical and thermal characteristics of PP/PA6/Boron sesquioxide composite. Water treatment caused polyamides to bind with water molecules, resulting in voids in the material. The interaction between boron sesquioxide and water molecules produced boric acid, which increased the tribological characteristics of the composite.

This paper aims to control the deformation of a thin wall CrZrCu cylinder components (wall thickness 5 mm, diameter 400 mm) during thermal spray alumina-titania (AT13) coating by adjusting the spray parameters without deteriorating its quality evidently.

The deformation was controlled by lowering the temperature of the component in the way of adjusting the spray parameters. The main parameters adjust included extending the spraying distance, from normally 120 mm to 140 mm, decreasing plasma power from 50to 42 kW. An alumina-titanium (AT13) ceramic coating was chosen for protecting the substrate from corrosion. Microscopic morphology and phase analysis, insulation resistance testing, neutral salt test and electrochemical method were used to analyze the anti-corrosion and insulation performances of the coating.

The results indicate that, after adjusting the spraying parameters, the coating has a relatively high porosity, with an average value of 8.96 ± 0.77%. The bonding strength of the coating is relatively low, with an average value of 17.69 ± 0.85 MPa. However, after sealing, the polarization resistance of the coating in seawater can be maintained above 6.25 × 10⁶ Ω.cm² for an extended period. The coating has a high resistance (=1.1 M Ω), and there is no apparent galvanic corrosion when contacted with TC4 alloy. Additionally, analysis of corrosion products on the sample surface reveals that the samples with sprayed alumina-titanium ceramic show no copper corrosion products on the surface, and the coating remains intact, effectively isolating the corrosive medium.

By adjusting the spraying parameters, the deformation of the cylinder thin-walled component can be effectively controlled, making the φ 400 × 392 mm (thickness 5 mm) CrZrCu cylinder com-ponent with a maximum diameter deformation of only 0.14 mm. The satisfactory corrosion performances can be achieved under adjusting spraying parameters, which can guarantee the application of ceramic coating for weapon launching system of naval ships.