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In this chapter the authors present a field study investigating the adoption of information communications technology innovation at a UK-based University hospital. The authors have followed the implementation of electronic medicine chart technology (EMEDs) designed to replace “traditional” paper-based systems used by doctors, nurses, and pharmacists teams in the hospital. Having studied the interactions between the “user” and “implementer” groups, the findings of this chapter offer a socio-cognitive model of innovation adoption which accounts for the intra- and inter-team idiosyncrasies that underpin the processes of implementation. Using the concept of interactive framing as the analytical lens, findings of this chapter illustrate that the adoption and diffusion process of innovation is a social process resulting from the interaction of organizational team members. The cycles constituting the adoption and implementation of EMEDs in this research encapsulate the conflicting experience of different groups and their transition from implementation to acceptance. The authors have adopted a socio-cognitive perspective to explain the asymmetrical experience of different groups in a complex, high reliable organization.