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For the past few years, in a purely competitive and dynamic environment, the supply chain plays a crucial role to adapt the business as it is very contingent on collaborative integration as well as flexibility. Many specialized applications are implemented to improve the flow control of the supply chain. One of the most important new technological applications in the supply chain is blockchain technology which has garnered the attention of many business owners as this technology can be quickly adapted to the dynamic business environment. Blockchain technology has been gaining importance and acceptability over the past few years. Blockchain technology has found significant success in all fields, including the banking and finance sector, health, manufacturing, transportation, and many others. Recently, the researchers have contributed significantly toward understanding blockchain technology and its application in the organizational and technology-specific factors that play a crucial role in driving its adoption in the supply chain. Blockchain technology plays a vital role to maintain trust among the stakeholder of the supply chain. The purpose of this chapter is to discuss a theoretical framework for blockchain adoption in the supply chain in business. The outcomes of this chapter endorse that companies invest in blockchain technology so that the supply chain becomes more transparent, flexible, and secure. In the end, this chapter has also given contemplations on the security issues of implementing blockchain in the field of collaboration and integration.