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This chapter outlines how the academic field in Germany, particularly universities as institutions of research and education, became a constitutive element in the process of digitalization. Institutions in higher education created long-lasting networks not only by scientific relations in the academic field but also by the establishment of business-oriented and application-oriented disciplines. This chapter focuses on the case of business information systems (BIS) and reconstructs the structural conditions under which BIS evolved from an initially marginal data-centric subfield of business administration into an independent discipline. This discipline has had a major influence on the transformation of work processes in recent decades and is an important player in the digital transformation in Germany. This chapter therefore also outlines the far-reaching implications of the paths taken, which are eventually not limited to the academic field but manifested in transformed work processes in almost all professional fields.