Ultrasonic spectrometry goes HTP

Citation

(2003), "Ultrasonic spectrometry goes HTP", Pigment & Resin Technology, Vol. 32 No. 4. https://doi.org/10.1108/prt.2003.12932dad.008

Ultrasonic spectrometry goes HTP

Ultrasonic spectrometry goes HTP

Keywords: Spectroscopy, Equipment

Ultrasonic Scientific introduces its first major product launch of the year with its new HR-US HTP high throughput spectrometer. Nominated for best new product at Pittcon 2003, the high resolution ultrasonic spectrometer – high throughput (HR-US HTP) is an enabling technology, which is sold to pharmaceutical organizations in the USA and Europe for a variety of applications. The new HTP ultrasonic spectrometer greatly improves throughput and productivity for routine or higher volume applications and has the added capability of semi-automated sample introduction. This allows for the fast filling, emptying and cleaning of the ultrasonic cells. It is ideal for analysis of large quantities of samples, to study batch to batch variation, sample stability, composition, the presence of crystals or aggregates, particle size etc., and also ideal for measuring a wide variety of liquid systems, from dilute solutions to concentrated emulsion.

The high resolution ultrasonic/acoustic spectrometer has the capacity for process development and monitoring in real time. One of the applications is concentration measurements, other related applications are ingredient and formulation consistency (composition, structure), process impurity analysis, batch to batch variation, etc. The technology can be used for static fingerprint measurements or for dynamic analysis of systems.

High resolution ultrasonic spectroscopy can address and solve many of these concerns. It provides capabilities for fast analysis of raw materials, intermediates for final products and allows fast adjustment of manufacturing parameters, thus achieving the desired quality of the final products. It allows the generation of information on product quality in real time.

Previously, pharmaceutical process monitoring involved temperature, pressure flows, pH and other physical parameters, and now ultrasonic spectroscopy can be used for on-line testing or for fast off-line testing as a primary means of ultrasonic process monitoring. This yields data which provide information on various stages of the process. The HR-US HTP has two 1 ml cells for parallel or differential sample analysis, variable speed pump system (speed from 130 to 25 ml/min), a frequency range of 2-18 MHz (cells with extended frequency range are available on request) and high resolution and reproducibility (10-5 per cent for velocity and 0.1 per cent attenuation).