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Synthesis of novel biologically active thiazole dyes and their applications

Sraa Abu-Melha (King Khalid University, Abha, Saudi Arabia)

Pigment & Resin Technology

ISSN: 0369-9420

Article publication date: 25 June 2019

Issue publication date: 21 August 2019



This study aims to focus on the possibility of developing new thiazole azo dyes with good colouristic application properties, biological and pharmacological activities.


Coupling of curcumin with different aromatic diazonium salts of 2-amino thiazole derivatives, such as 2-aminobenzothiazole, 2-amino-5-phenylthiazole, 2-amino-5-methylthiazole and 2-amino-5-nitrothiazole-produced novel azo dyes. Structures of all synthesised dyes were fully confirmed via spectroscopic and analytical methods. Those compounds were examined for their antimicrobial, anticancer and antioxidant activities. They were applied on polyester fabrics and, subsequently, their dyeing properties, light, washing, perspiration, rubbing and sublimation fastness were determined.


Prepared dyestuffs were suitable for dyeing polyester fabrics. It was found that all prepared dyes possess high colour strength, as well as good overall fastness properties. Meanwhile, the synthesised compounds exhibited good biological and pharmacology activity.

Research limitations/implications

Synthesis of these four azo dyes for textile dyeing was not conveyed earlier.

Practical implications

Thaizolyl disperse dyes were responsible for giving better colour assessment and fastness properties on polyester fabrics.

Social implications

Although, most of synthesis eco-friendly dyes are expensive, they are showing a good antimicrobial and anticancer activity.


It gave straightforward approach to synthesise novel thiazolyl azo dyes with good biological, pharmacology activities, good colour assessment, and fastness properties.



Abu-Melha, S. (2019), "Synthesis of novel biologically active thiazole dyes and their applications", Pigment & Resin Technology, Vol. 48 No. 5, pp. 375-382.



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