Average intakes of vitamin B6 are equal to, or greater than, reference nutrient intakes and clinical deficiency disease due to inadequate dietary intake is unknown. Although there is little scientific evidence of efficacy, the vitamin is widely recommended for treatment of premenstrual syndrome at levels of 50‐100mg/day (compared with reference nutrient intakes of under 2mg/day). At higher levels of intake (over 1,000mg/day), there is clear evidence of nerve damage, and there have been reports of symptoms of nerve damage in people taking between 50‐100mg/day.
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