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This study aims to study the connected vehicle (CV) impact on highway operational performance under a mixed CV and regular vehicle (RV) environment.

The authors implemented a mixed traffic flow model, along with a CV speed control model, in the simulation environment. According to the different traffic characteristics between CVs and RVs, this research first analyzed how the operation of CVs can affect highway capacity under both one-lane and multi-lane cases. A hypothesis was then made that there shall exist a critical CV penetration rate that can significantly show the benefit of CV to the overall traffic. To prove this concept, this study simulated the mixed traffic pattern under various conditions.

The results of this research revealed that performing optimal speed control to CVs will concurrently benefit RVs by improving highway capacity. Furthermore, a critical CV penetration rate should exist at a specified traffic demand level, which can significantly reduce the speed difference between RVs and CVs. The results offer effective insight to understand the potential impacts of different CV penetration rates on highway operation performance.

This approach assumes that there shall exist a critical CV penetration rate that can maximize the benefits of CV implementations. CV penetration rate (the proportion of CVs in mixed traffic) is the key factor affecting the impacts of CV on freeway operational performance. The evaluation criteria for freeway operational performance are using average travel time under different given traffic demand patterns.

Based on DNase I and reduced graphene oxide (rGO)-magnetic silicon microspheres (MNPS), a highly sensitive and selective fluorescent probe for the detection of PD-L1 was developed.

Here °C we present a feasibility of biosensor to detection of PD-L1 in lung tumors plasma. In the absence of PD-L1°C the PD-L1 aptamer is absorbed on the surface of graphene oxide modified magnetic nanoparticles °8rGO-MNPS°9 and leading to effective fluorescence quenching. Upon adding PD-L1°C the aptamer sequences could be specifically recognized by PD-L1 and the aptamer/PD-L1 complex is formed°C resulting in the recovery of quenched fluorescence.

This sensor can detect PD-L1 with a linear range from 100 pg mL⁻¹ to 100 ng mL⁻¹, and a detection limit of 10 pg•m⁻¹ was achieved.

This method provides an easy and sensitive method for the detection of PD-L1 and will be beneficial to the early diagnosis and prognosis of tumors.