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This work proposes a methodology to project future freight demand for all commodity types that begin and end in each geographical region and the amount of freight that moves between all origin and destination pairs. Following the traditional four-step demand forecasting framework, the procedure corresponds to trip generation and trip distribution analysis for interregional freight demand. Using future economic growth factors from macroeconomic and input-output models, the amounts of freight production and attraction in each analysis zone are forecasted and taken as given. Subsequently, an iterative matrix balancing method is applied to determine the estimated freight shipment demand for all origin and destination zone pairs. The proposed algorithm is applied to generate predicted future freight demand within the United States from 2010-2050 in five-year increments based on the national freight demand data from 2007. Four different scenarios are proposed that consider variations in both global economic growth and environmental regulation. This study will assist transportation planners and decision makers in public and private sectors to assess how future freight delivery demand on the national scale considering various future global economic growth and environmental policy scenarios will affect various issues such as air quality and human health problems.