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One of the most profitable industries worldwide is automotive manufacturing, with an estimated economic impact of 2.9 trillion dollars, which employs 8% of the economically active world population, both directly and indirectly. The main 12 world powers in the automotive sector account for 80% of the total manufactured vehicles, and Mexico ranks seventh in the world and is part of the free trade agreement in the Pacific Alliance (PA). This fact may have a direct impact on boosting the domestic automotive industry in Mexico by leveraging the manufacturing supply chain in primary and secondary industries in the three commercial partners: Chile, Colombia, and Peru. This chapter found that there is a coincidence in the competitiveness pillars of the Mexican automotive industry and its business partners in the PA. This presents a strategic panorama of competition and economic development for the region.