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An entrepreneurial mode is the latest stage in the evolution of the scientific role. Earlier phases included the differentiation of the modern experimental scientific role from natural philosophy in the mid 17th century. Indeed, the creation of the scientific role preceded the invention of the term “scientist” by Cambridge philosopher of science, William Whewell, in 1834 to describe Mary Somerville, a unique researcher. A transition from amateur to professional scientist followed in the mid 19th century, exemplified by another female scientist, Maria Mitchell, who carried out her astronomic investigations at home until she was appointed to an academic post in middle age (Bergland, 2008). A transition from basic researcher to entrepreneurial scientist is currently underway as part of a broader reconstruction of innovation systems from double helix (government–university or government–industry) to a university–industry–government triple helix (Etzkowitz, 2008). Each transformation in the scientific role reflected a change in the role of knowledge in the political economy. Thus, experimental science provided the instrumentation that allowed ocean commerce to be carried on in a secure fashion; professional science discoveries that were scaled up to provide the basis for the chemical and dye industries. Entrepreneurial academic scientists in collaboration with venture capitalists, building upon a substrate of government-funded research, created the biotechnology industry.