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To solve the problems caused by using precise molds for copper column positioning in the current column grid array package, this paper aims to optimize the proposed friction plunge micro-welding (FPMW) technology without mold assistance, to overcome the problems of low interfacial bonding strength, shrinkage cavities and flash defects caused by the low hold-tight force of solder on the copper column.

A pressurizing device installed under the drill chuck of the friction welding machine is designed, which is used to apply a static constraint to the solder ball obliquely downward to increase the hold-tight force of the peripheral solder on the copper column during welding and promote the friction metallurgical connection between them.

The results show that the application of static constraint during welding can increase the compactness of the solder near the friction interface and effectively inhibit occurrences of flash, shrinkage cavities and crystal defects such as vacancies. Therefore, compared with the unconstrained (UC) FPMW, the average strength of the statically constrained (SC) FPMW joints and aged SC-FPMW joints can be increased by 51.1% and 122.6%, and the problem of the excessive growth of the interfacial connection layer in the UC-FPMW joints during aging can be effectively avoided.

The application of static constraint effectively inhibits the occurrence of defects such as shrinkage cavities, vacancies and flash in FPMW joints, and the welding quality is significantly improved.

This study aims to develop a simplified bioink preparation method that can be applied to most hydrogel bioinks used in extrusion-based techniques.

The parameters of the bioprinting process significantly affect the printability of the bioink and the viability of cells. In turn, the bioink formulation and its physicochemical properties may influence the appropriate range of printing parameters. In extrusion-based bioprinting, the rheology of the bioink affects the printing pressure, cell survival and structural integrity. Three concentrations of alginate-gelatin hydrogel were prepared and printed at three different flow rates and nozzle gauges to investigate the print parameters. Other characterizations were performed to evaluate the hydrogel structure, printability, gelation time, swelling and degradation rates of the bioink and cell viability. An experimental design was used to determine optimal parameters. The analyses included live/dead assays, rheological measurements, swelling and degradation.

The experimental design results showed that the hydrogel flow rate substantially influenced printing accuracy and pressure. The best hydrogel flow rate in this study was 10 ml/h with a nozzle gauge of 18% and 4% alginate. Three different concentrations of alginate-gelatin hydrogels were found to exhibit shear-thinning behavior during printing. After seven days, 46% of the structure in the 4% alginate-5% gelatin sample remained intact. After printing, the viability of skin fibroblast cells for the optimized sample was 91%.

This methodology offers a straightforward bioink preparation method applicable to the majority of hydrogels used in extrusion-based procedures. This can also be considered a prerequisite for cell printing.