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To meet the increasing needs for ubiquitous healthcare, a mobile phone‐based system for monitoring multiple vital signs is under development. In this paper, design and implementation of the system architecture are described. The hierarchy of this system comprises three layers, which respectively handle multiple vital signs sensing, data/command communication via either wireless or wired means, and healthcare management. The fundamental basis of the sensing layer is a wearable cordless sensor device for monitoring vital signs without discomfort to the user during daily activities. The data communication layer performs bi‐directional information exchange between the sensing layer and the management layer. The uppermost management layer conducts data mining and analysis for risk factors assessment and healthcare. Overall considerations of implementation method and prototype fabrication are outlined. Finally, applicability to a variety of real‐world situations, and provision of customizable solutions not only for home healthcare but also for other vital signs‐related domains (such as emergency rescue and safety guarantee) are discussed. Three of the most promising applications based upon this system are described.