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This study aims to integrate design methods and additive manufacturing with the use of a thermoplastic elastomer certified for medical use and reverse engineering towards a new concept of a customized buttress model with optimized features for the reconstruction of the osteo-dural opening after endoscopic endonasal transtuberculum-transplanum approach.

Additive manufacturing allows making of cost-effective and useable devices with tailored properties for biomedical applications. The endoscopic endonasal approach to the suprasellar area enables the management of different intradural tumours, and the craniectomy at the skull base is generally wide and irregular. Defining an optimal strategy for osteodural defect closure at the preoperative stage represents a significant challenge.

Using the results obtained from a computed tomography analysis, skull base defects were designed to plan the surgical approach. Several concepts of customized buttress models were first built up, initially focusing on thin, flexible edges characterized by different thicknesses. Finite element analyses and design optimization allowed us to achieve the optimal design solution with improved compliance/flexibility for easy intranasal manoeuvrability, maintaining an adequate mechanical stability. As the thickness of the edges decreased, an increase of strain energy values was found (i.e. 1.2 mJ – Model A, 1.7 mJ – Model B, 2.3 mJ – Model C, 4.3 mJ – Model D). However, a further optimization (Model E) led to a significant increase of the compliance (strain energy of 14.1 mJ).

The results obtained from clinical evaluations demonstrated the feasibility of the proposed technical solutions, improving surgery effectiveness.

Identifying the health-related needs in transgender (TG) people can help to formulate strategies for providing appropriate and accessible health services and promoting health and social justice, as well as human rights in these populations. This systematic review aims to determine health-related needs, problems and barriers, as well as ways to solve them in TG people from the viewpoint of TG individuals and health policymakers.

All international electronic databases such as PubMed (Medline), Embase, CINAHL, Scopus, Web of Sciences, Cochrane, PsycInfo and Google Scholar (Gray Literature) were searched from December 1990 to December 2019. After the search, the articles were screened based on their title, abstract and full text. The quality of articles was assessed using the Strengthening the reporting of observational studies in epidemiology (STROBE), Consolidated Standards of Reporting Trials (CONSORT) and Standards for Reporting Qualitative Research (SRQR) checklists. The search strategy, data extraction and quality evaluation of articles were independently performed by two researchers.

The general health-related needs identified in TG individuals from the viewpoint of themselves included access to legal hormone therapy, psychological and psychiatric counseling, privacy, health and hygiene needs, equality and freedom of expression. General health-related needs in TG individuals from the viewpoint of health policymakers included screening tests to detect sexually transmitted diseases, especially HIV, cancers and other diseases, as well as training service providers (physicians, nurses, health workers, etc.).

One of the limitations of this study was nonreporting of health-related needs in initial articles by different TG groups because these groups have had different needs and different barriers to accessing health-care services. In this study, health-related needs and barriers to satisfy them were categorized from the viewpoint of TG populations and health policymakers around the world, which may influence future decisions to provide services to TG populations. The results of this systematic review can help to develop different strategies by considering all TGs from individual, family and social aspects to better provide services for this group. However, given the dynamics and changes in the existing communities and the limited studies on gender minorities in developing countries, further research is required to comprehensively address the subject.

The findings can be used as an incentive to improve existing conditions and to address problems and shortcomings. The results of this systematic review formulate strategies for providing appropriate and accessible health services and better lives for TGs, planning for more effective participation of these individuals in local communities, improving their physical problems and mental health through counseling, as well as promoting health and social justice, and human rights for these populations.

Sustainable urban development involves integrating intelligent technology into urban planning to promote economic growth, social services, and environmental preservation. It fosters inclusiveness, safety, resilience, and sustainability in urban environments. However, this strategy faces challenges balancing economic growth, social equality, and environmental preservation. Design experts must balance economic development with sustainability preservation to achieve sustainable urban development. They depend on technology for smarter communities. The paper aims to identify the criteria for sustainable urban design and design professionals' bias and their awareness of using the fourth industrial revolution technologies.

The research methodology involves a document review to identify criteria and weights for sustainable urban design. A questionnaire was conducted with 30 design professionals to understand their preferences and biases. A hierarchical framework was created, and pairwise comparisons were computed using an AHP Online System. The weight of each criterion was calculated by aggregating normalized pairwise values within each row and dividing by the total number of cells. The Consistency Ratio (CR) was determined by aggregating the values in the row to produce the weighted aggregate value for each principle.

The document review emphasizes the significance of sustainable urban design, livability, intelligence, and environmental conservation in sustainable communities. However, participants often overlook these aspects, focusing on comfort, privacy, security, and exclusiveness. They also ignore the need for smart city technologies and environmental protection. This lack of understanding may hinder Egypt’s achievement of SDG11.

The paper’s main limitation is the small sample size and composition, as all participants were Egyptians working in Egypt or the Arabian Gulf region. The findings cannot be generalized, and future research could involve a team from different regions. Egypt needs to address the lack of knowledge and awareness of sustainable urban design principles among design professionals to achieve SDG 11 goals. This can be achieved through educational initiatives, readjusting priorities towards sustainability, harmonizing policy and practice with sustainable urban design principles, and interdisciplinary teamwork. Design professionals should customize their methods to suit local requirements and ecological circumstances.

The paper reveals that many design professionals lack an integrated and holistic understanding of sustainable urban design principles that the document review outlined. Their responses and practices reveal an incomplete understanding of sustainable urban development, requiring attention to organizing the profession, training practitioners, and reforming planning education. The paper shows that AHP has the potential to serve as a suitable instrument for decision-making; nonetheless, it is essential to exercise caution when interpreting its outcomes.