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The purpose of this paper is to investigate the role of illness-related worries as a mediator among depression, anxiety and self-care in heart failure (HF) patients was the aim of this study.

This study was descriptive and correlational study. In total, 149 patients with HF were selected for sampling in 2016. Patients completed self-care behavior scale, illness-related worries questionnaire and Depression Anxiety Stress Scale (DASS) questionnaires. The Pearson correlation coefficient and Sobel test were also done.

According to the analysis of the Sobel test, the role of illness-related worries as a mediator in the relationship between depression and self-care result was −5.37. Sobel test analysis was done to assess the role of illness-related worries as mediator between anxiety and self-care (6.66). The correlation between depression and self-care was 0.488 (p<0.01); correlation between anxiety and self-care was 0.4 (p<0.01); correlation between anxiety and depression was 0.79 (p<0.01); and the correlation between illness-related worries and self-care was 0.71 (p<0.01).

Illness-related worries can serve as a mediator in the relationship among depression, anxiety and self-care. There was a significant correlation among the research variables. Therefore, educational programs to reduce depression, anxiety and increase self-care should be given priority to for HF patients.