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The purpose of this chapter is to explore the challenges of health emergency communication as presented in the COVID-19-related research articles in the fields of organisational communication, strategic communication and public relations published between 2020 and mid-2022. A qualitative literature review consisting of two rounds of data selection and ATLAS.ti-assisted content analysis was conducted. The data include 67 articles published in quality journals of communication studies, with a focus on the abstract, results and discussion sections. The findings emphasise the need for emotional support, empathy and both vertical and horizontal informal communication in uncertainty reduction during a major health emergency. The limitations of the study include that the data are limited to the first published journal articles concerning the consequences of COVID-19 and that it comprises publications in communication studies but not related fields, such as health, psychology or management. However, it provides an overview of the research findings and offers guidelines for managers and communication professionals for the development of communication practices under the threat of a major health crisis. Moreover, it proves the importance of healthy and trustful workplace relationships as a prerequisite for coping with uncertainty. All in all, the study provides a good basis for further studies of organisational communication and health emergencies.