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The purpose of this paper is to study the effect of chronic consumption of fresh palm oil (FPO) and thermoxidized palm oil (TPO) diet on gastric acid secretion, pepsin secretions, gastric mucus output and gastric cytoprotection.

Adult Wistar rats were randomly assigned into three groups, i.e. control, FPO and TPO groups (n = 10 in each). The control group was fed with normal rat chow only, the FPO group was fed on diet containing 15 per cent v/w FPO and the TPO group was fed with diet containing v/w of thermally oxidized palm oil. All animals had free access to feed and water, and the feeding lasted for 14 weeks. At the end of the feeding period, gastric acid secretion, pepsin secretion, mucus output and gastric ulceration were measured following standard methods.

There was increase in histamine-stimulated gastric acid output in the TPO diet-fed group (p < 0.01) compared with the control and FPO diet-fed groups. No significant change in the mucus output was observed across all the experimental groups; whereas, pepsin secretion was significantly higher (p < 0.05) in the TPO diet-fed group (0.46 ± 0.27) compared with the control (0.14 ± 0.05) and FPO diet-fed groups (0.25 ± 0.01). Ulcer scores in the TPO diet-fed group (15.5 ± 0.33) was significantly higher (p < 0.01) compared with the control (10.0 ± 0.05) and FPO diet-fed (5.0 ± 0.04) groups.

Chronic consumption of TPO increased gastric acid and pepsin secretion (gastric-aggressive factors) without a change in the mucus output. This can bring about gastric ulceration; therefore, the liberal use of TPO should be discouraged.

The purpose of this paper is to assess participants’ perception that tramadol enhances physical work performance and acts as a pain relief.

The participants were 30 (18 male and 12 female) tramadol-using emerging adults, aged 16–27 years, selected through respondent-driven sampling. The majority of the participants were university students, whereas others had completed senior secondary education. The study adopted a qualitative design. Qualitative data were analysed using thematic analyses.

In general, respondents perceived and used tramadol for pain relief and physical work performance enhancement. The result showed that sex, employment status and daily dosage were not associated with respondents’ perception of tramadol as a pain-relieving medication. In contrast, sex and employment status were associated with participants’ perception of tramadol as a physical work performance enhancement medication, but daily dosage was not.

Some users refused to participate because they were afraid of being exposed to law enforcement.

Male and female emerging adults are involved in non-medical use of tramadol. Prevention and intervention programs to reduce or stop this behaviour are needed, especially in the rural communities.

The result showed that users were mostly from poor homes, whose parents could not afford university education and who were not qualified to get good government paying jobs. So, the use of tramadol became necessary for them to make more money from the kind of jobs they did. Reduction of the cost of university education and provision of regular jobs for this population are some of the measures recommended to counter non-medical use of tramadol by this population.

This is the first study in South-eastern Nigeria that focused on the non-medical use of tramadol among emerging adults, using a qualitative design.