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This study evaluates machine learning (ML) classifiers for diagnosing Parkinson’s disease (PD) using subcortical brain region data from 3D T1 magnetic resonance imaging (MRI) Parkinson’s Progression Markers Initiative (PPMI database). We aim to identify top-performing algorithms and assess gender-related differences in accuracy.

Multiple ML algorithms will be compared for their ability to classify PD vs healthy controls using MRI scans of the brain structures like the putamen, thalamus, brainstem, accumbens, amygdala, caudate, hippocampus and pallidum. Analysis will include gender-specific performance comparisons.

The study reveals that ML classifier performance in diagnosing PD varies across subcortical brain regions and shows gender differences. The Extra Trees classifier performed best in men (86.36% accuracy in the putamen), while Naive Bayes performed best in women (69.23%, amygdala). Regions like the accumbens, hippocampus and caudate showed moderate accuracy (65–70%) in men and poor performance in women. The results point out a significant gender-based performance gap, highlighting the need for gender-specific models to improve diagnostic precision across complex brain structures.

This study highlights the significant impact of gender on machine learning diagnosis of PD using data from subcortical brain regions. Our novel focus on these regions uncovers their diagnostic potential, improves model accuracy and emphasizes the need for gender-specific approaches in medical AI. This work could ultimately lead to earlier PD detection and more personalized treatment.

Accurate diagnosis of brain tumors is crucial for effective treatment and improved patient outcomes. Magnetic resonance imaging (MRI) is a common method for detecting brain malignancies, but interpreting MRI data can be challenging and time-consuming for healthcare professionals.

An innovative method is presented that combines deep learning (DL) models with natural language processing (NLP) from ChatGPT to enhance the accuracy of brain tumor detection in MRI scans. The method generates textual descriptions of brain tumor regions, providing clinicians with valuable insights into tumor characteristics for informed decision-making and personalized treatment planning.

The evaluation of this approach demonstrates promising outcomes, achieving a notable Dice coefficient score of 0.93 for tumor segmentation, outperforming current state-of-the-art methods. Human validation of the generated descriptions confirms their precision and conciseness.

While the method showcased advancements in accuracy and understandability, ongoing research is essential for refining the model and addressing limitations in segmenting smaller or atypical tumors.

These results emphasized the potential of this innovative method in advancing neuroimaging practices and contributing to the effective detection and management of brain tumors.