Device for the release of biologically active agents

Citation

Rigelsford, J. (2001), "Device for the release of biologically active agents", Sensor Review, Vol. 21 No. 3. https://doi.org/10.1108/sr.2001.08721cad.027

Device for the release of biologically active agents

Device for the release of biologically active agents

Applicant: IsoTis B.V. HollandPatent number: US6143948Publication date: 7 November 2000Title: Device for incorporation and release of biologically active agents

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance. The present invention further relates to a process of producing such a device and to the biomedical use of such a device.