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There is high incidence of dementia in individuals with Down’s syndrome. Much of the emphasis has been on Alzheimer’s disease as being most prevalent; however, it is apparent that other dementia types are also likely, to which this patient cohort may be predisposed. Specifically, this paper aims to highlight the potential for subcortical dementias in Down’s syndrome, suggesting a role for broader cognitive screening in aging individuals.

This paper describes a case of a female with Down’s syndrome and mild intellectual disability who presented with early signs of distinctive cognitive impairment and radiological calcification of the basal ganglia.

An active 42-year-old lady, who was mostly independent of activities of daily living and in part-time employment, presented with a three-year history of progressive cognitive deficit, characteristic of subcortical decline. She had no personal or known family history of mental illness, epilepsy or dementia. Routine blood tests showed chronic renal impairment, mild hypocalcaemia and vitamin D deficiency, managed by her GP. CT scan showed only bilateral basal ganglia calcification.

There is a widespread appreciation for the link between Down’s syndrome and Alzheimer’s disease but lesser consideration of the possibility of subcortical dementias. Given the differential nature and presentation of the two dementias, this case report highlights a need for clinicians to consider both to effectively manage these patients in the longer-term. Screening is discussed as a potential means of achieving this.

Clozapine is a well-known antipsychotic medication licensed for treatment-resistant schizophrenia, but there is limited research available to suggest its efficacy in the context of personality disorder and intellectual disabilities presenting with high-risk behaviour with or without psychotic symptoms. The purpose of this paper is to raise awareness of the benefits of using clozapine in patients with intellectual disabilities and personality disorder that present with a complex picture of serious risk of harm to both their life and the lives of others.

The authors present five patients with intellectual disabilities and serious life-threatening challenging behaviour whom were started on clozapine as part of their multidisciplinary treatment plan to manage their presentation. The authors completed baseline assessment of five main symptom domains and then repeated this assessment following treatment with clozapine.

In all five cases use of clozapine was objectively associated with an improvement in symptomatology, quality of life and a safe transfer to the community.

The findings suggest that judicious use of clozapine could be considered as one of the effective pharmacological strategies in the management of patients with intellectual disabilities and personality disorder who present with serious life-threatening challenging behaviours.

Mental health problems, particularly psychotic symptoms, are associated with polycystic ovary syndrome (PCOS) which may be linked to oestrogen signalling cascade following a period of sustained high oestrogen and dysregulation of cortisol. This case report aims to demonstrate a potential link and improvement following the use of Metformin.

The paper describes a case of a female with intellectual disability who presents with psychosis coinciding with PCOS and the aetiology of this association.

The case highlights some key points and complexities encountered in diagnosing and managing an individual with mental and physical health issues and an underlay of family dynamics and insecure attachment. A treatment approach involving recommendations from and joint working between professional groups including endocrinology, is highlighted.

There are very few studies to date that link PCOS to psychosis and only a single case report describes the use of Metformin. In a patient presenting with psychosis and PCOS, the consideration of an association with hormonal changes should be made, especially in patients with changing severity of psychosis and poor response to psychiatric medication. A “multimodal” intervention package needs to be considered for optimum benefit.

Understanding China's carbon dioxide (CO2) emission status is crucial for getting Carbon Neutrality status. The purpose of the paper is to calculate two possible scenarios for CO2 emission distribution and calculated input-output flows of CO2 emissions for every 31 China provinces for 2012, 2015 and 2017 years.

In this study using the input and output (IO) table's data for the selected years, the authors found the volume of CO2 emissions per one Yuan of revenue for the industry in 2012 and the coefficient of emission reduction compared to 2012.

Results show that in the industries with a huge volume of CO2 emissions, such as “Mining and washing of coal”, the authors cannot observe the reduction processes for years. Industries where emissions are being reduced are “Processing of petroleum, coking, nuclear fuel”, “Production and distribution of electric power and heat power”, “Agriculture, Forestry, Animal Husbandry and Fishery”. For the “construction” industry the situation with emissions did not change.

“Transport, storage, and postal services” and “Smelting and processing of metals” industries in China has the second place concerning emissions, but over the past period, emissions have been sufficiently reduced. “Construction” industry produces a lot of emissions, but this industry does not carry products characterized by large emissions from other industries. Authors can observe that Jiangsu produces a lot of CO2 emissions, but they do not take products characterized by significant emissions from other provinces. Shandong produces a lot of emissions and consumes many of products characterized by large emissions from other provinces. However, Shandong showed a reduction in CO2 emissions from 2012 to 2017.

Power and politics.

This case is suitable for all levels of students, undergraduate MBA to Executive MBA classes and practitioners. Assignment questions are designed from the perspective of teaching this case to a business student audience.

A raging dispute between Kerala and Tamil Nadu over the 116-year-old Mullaperiyar Dam was in the national spotlight after mild tremors shook nearby areas. The Mullaperiyar Dam was located in Idukki district of Kerala in India. The dam was filled to its maximum permissible level of 136 ft. Tamil Nadu wanted the storage capacity to be increased by raising the dam height from 136 ft (41.5 m) to 142 ft (43 m) as per a 2006 Supreme Court directive to meet the growing irrigation needs of the state. The dam was vital for people living in the drought-prone districts of Theni, Dindigul, Madurai, Sivagangai and Ramanathapuram of Tamil Nadu. It irrigated about 220,000 acres and supplied drinking water to Madurai city and several towns. Kerala on the other hand wants a new dam as it feared that a strong earthquake might damage the existing dam. Chief Minister of Kerala, Oommen Chandy said: “I strongly believe that only a new dam can provide safety to the people of Kerala. We are only concerned about the safety of the people. But, unfortunately, there is a feeling in Tamil Nadu that the situation of panic here is a created one. That is not at all correct”. However, Tamil Nadu Government said the dam was safe as it had undergone periodic repairs during 1980-1994 with Kerala Government's approval. With the Kerala Government screaming loud over the danger that could be caused by the alleged obsolete 116 year old Mullaperiyar Dam on safety grounds of people who live downstream, why is Tamil Nadu defiant on any debate that cites the decommission of the controversial dam? Is the Tamil Nadu Government overlooking the issue for its personal benefits by putting the lives of 3 million people at stake?

The case would fit in a course for power and politics. It would also be appropriate for a modular course on regional development planning.

Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

While the obstacles of archiving endangered languages are significant, the question of which platform is best for building a digital language archive is constantly present. The purpose of this study is to evaluate and analyse digital language archives development platforms, such as content management systems (CMSs), digital repositories and archival collections management systems (ACMSs) using parameters that have been specified. The authors selected Mukurtu CMS, which is based on Drupal CMS; DSpace as the digital repository software; and ArchivesSpace as an ACMS in this study.

The current research is supported by a study of the literature and a detailed exploration of different systems used to develop digital language archives. The whole research is carried out in three steps: literature searching; identification of relevant literature; and parameter identification, exploration of tools and data reporting and analysis.

Following the technical and feature analysis of these tools, it can be concluded that they are more or less comparable, as well as constantly evolving, updating and having a bigger community base. It may be determined that DSpace is the most popular platform, but the other two, particularly ArchivesSpaces, are fierce competitors.

This study outlines the technical prerequisites for creating a digital language archive, which will be useful to IT personnel working on these projects. The research is also useful for tool developers as it allows them to incorporate missing functionality and technical standards by comparing them to alternatives. The parameters established in this study can be used for similar studies in other domains, as well as for evaluating existing digital language archives.

The findings of this study have broad practical implications, and they can assist archivists, linguists, language communities and library and information science professionals in choosing an appropriate platform for building a digital language archive.

This study finds that there is relatively little effort made towards reviewing digital language archiving and the systems that are used to do it; thus, this study is carried out to assess and analyse digital language archive creation systems based on defined parameters. The parameters were discovered through a combination of the available literature and tool discovery. Using a parametric approach to evaluate tools yields unique insights and quickly reveals system flaws.

High-performance work systems (HPWSs) are linked to performance, but few studies explore creativity behaviours (CBs). The present study includes job satisfaction as a mediator, and firm size and competitive rivalry as moderators to better understand the context.

Data were collected using a sample of 310 New Zealand managers. Data analysis was a moderated mediation analysis in structural equation modelling using Mplus.

The authors find HPWSs are directly related to CBs and job satisfaction, with job satisfaction fully mediating HPWS effects. Two-way moderation effects show managers in small firms report the highest CBs with high HPWSs, and a significant moderated mediation effect is found with firm size, showing a strong positive indirect effect from HPWS, which diminishes as firm size increases.

HPWSs hold the key to providing managers with opportunities for enhancing their CBs. Exploring the distinct bundles of HPWSs in the present study provides avenues for firms to understand and expand their influence on managers.

The findings of firm size as a boundary condition provides unique insights that aid our understanding of the effectiveness of HPWSs on CBs, and how small-sized New Zealand firms might extract better advantages from HPWSs. A major contribution is testing external firm factors (size and the business environment) to understand what roles they may play on managers’ creativity.