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1 – 10 of 581John D. Salamone and Mercè Correa
Classical definitions of motivation typically involve two main components: direction and activation. Motivated behavior is directed toward or away from particular stimuli (i.e.…
Abstract
Classical definitions of motivation typically involve two main components: direction and activation. Motivated behavior is directed toward or away from particular stimuli (i.e., appetitive and aversive motivation). Furthermore, activational aspects of motivation refer to the observation that motivated behavior is characterized by substantial activity, vigor, persistence, and exertion of effort in both the initiation and maintenance of behavior. Although separate neural systems direct organisms toward distinct motivational stimuli (e.g., food, water, sex), there appears to be a common circuitry regulating behavioral activation and the exertion of effort. Mesolimbic dopamine is one of the brain systems mediating activational aspects of motivation and exertion of effort. This system integrates aspects of motivation and motor control functions involved in the instigation of action. Research on the neurobiology of effort has contributed to our understanding of the pathophysiology of neurological and psychiatric disorders that are characterized by motivational dysfunction.
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Corinna Laube and Wouter van den Bos
Teenagers are typically described as impulsive and risk taking. Yet recent research shows that this observation does not hold in all contexts. Rather, adolescents show higher…
Abstract
Teenagers are typically described as impulsive and risk taking. Yet recent research shows that this observation does not hold in all contexts. Rather, adolescents show higher impulsivity and risk taking than children or adults in affective contexts. Motivational and affective processes are therefore of particular interest when trying to understand typical adolescent behavior. Additionally, pubertal hormones are hypothesized to play a special role in adolescents’ motivated decision making. However, evidence for the mechanisms underlying this relationship is sparse. In this chapter, we aim to integrate findings from human and animal studies in order to elucidate the specific impact of pubertal hormones on motivational processes in adolescence. Against this background, we critically discuss and reinterpret recent findings in psychology and neuroscience, speculate about underlying mechanisms, and suggest new approaches for future studies of adolescent behavior.
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Vishnu P. Murty and Kathryn C. Dickerson
Motivation significantly influences learning and memory. While a long history of research has focused on simple forms of associative learning, such as Pavlovian conditioning…
Abstract
Motivation significantly influences learning and memory. While a long history of research has focused on simple forms of associative learning, such as Pavlovian conditioning, recent research is beginning to characterize how motivation influences episodic memory. In this chapter we synthesize findings across behavioral, cognitive, and educational neuroscience to characterize motivation’s influence on memory. We provide evidence that neural systems underlying motivation, namely the mesolimbic dopamine system, interact with and facilitate activity within systems underlying episodic memory, centered on the medial temporal lobes. We focus on two mechanisms of episodic memory enhancement: encoding and consolidation. Together, the reviewed research supports an adaptive model of memory in which an individual’s motivational state (i.e., learning under states of reward or punishment) shapes the nature of memory representations in service of future goals. The impact of motivation on learning and memory, therefore, has very clear implications for and applications to educational settings.
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Yi Liu, Hao Wang, Yongfeng Liu, Meng Shi and Duolong Di
The purpose of this paper is to focus on the selection of the optimum porous material modified with poly-dopamine coating for peptides enrichment. The adsorption behaviors for…
Abstract
Purpose
The purpose of this paper is to focus on the selection of the optimum porous material modified with poly-dopamine coating for peptides enrichment. The adsorption behaviors for peptides and the antioxidant capacity of peptides fraction purified by the porous materials were investigated.
Design/methodology/approach
The optimum porous material with the highest adsorption capacity for peptides was selected for surface modification. The surface modified porous material was characterized by SEM, nitrogen adsorption-desorption isotherm and color change.
Findings
The results showed that the porous material was successfully modified with poly-dopamine coating. Adsorption capacity for peptides of the modified porous material was enhanced compared to the original porous material. Antioxidant capacity of peptides fraction enriched by the modified porous material was much higher than that enriched by the original porous material, indicating that the introduction of poly-dopamine coating was inclined to enrich peptides with certain amino acid residues.
Research limitations/implications
The structures of peptides are a bit not clear, which is the subject of future investigation.
Practical implications
This contribution provides a method to design and prepare porous materials with poly-dopamine coating to separate and enrich peptides or peptides fraction with high antioxidant capacity.
Originality/value
It showed that polarity, surface area, pore diameter and interactions were contributed to high adsorption capacity. The peptides fraction purified by the modified porous material showed excellent antioxidant capacity through results of reduction of DPPH radical, because of the enrichment of the peptides with certain amino acids residues which were considered to enhance radical scavenging capacity. This paper provides new insights into designing and preparing porous materials with poly-dopamine coating to enrich peptides fraction with high antioxidant capacity.
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Although first rank symptoms focus on positive symptoms of psychosis they are shared by a number of psychiatric conditions. The difficulty in differentiating bipolar disorder from…
Abstract
Although first rank symptoms focus on positive symptoms of psychosis they are shared by a number of psychiatric conditions. The difficulty in differentiating bipolar disorder from schizophrenia with affective features has led to a third category of patients often loosely labeled as schizoaffective. Research in schizophrenia has attempted to render the presence or absence of negative symptoms and their relation to etiology and prognosis more explicit. A dichotomous population is a recurring theme in experimental paradigms. Thus, schizophrenia is defined as process or reactive, deficit or non-deficit and by the presence or absence of affective symptoms. Laboratory tests confirm the clinical impression showing conflicting responses to dexamethasone suppression and clearly defined differences in autonomic responsiveness, but their patho-physiological significance eludes mainstream theory. Added to this is the difficulty in agreeing to what exactly constitutes useful clinical features differentiating, for example, negative symptoms of a true deficit syndrome from features of depression. Two recent papers proposed that the general and specific cognitive features of schizophrenia and major depression result from a monoamine-cholinergic imbalance, the former due to a relative muscarinic receptor hypofunction and the latter, in contrast, to a muscarinic hypersensitivity exacerbated by monoamine depletion. Further development of these ideas will provide pharmacological principles for what is currently an incomplete and largely, descriptive nosology of psychosis. It will propose a dimensional view of affective and negative symptoms based on relative muscarinic integrity and is supported by several exciting intracellular signaling and gene expression studies. Bipolar disorder manifests both muscarinic and dopaminergic hypersensitivity. The greater the imbalance between these two receptor signaling systems, the more the clinical picture will resemble schizophrenia with bizarre, incongruent delusions and increasingly disorganized thought. The capacity for affective expression, by definition a non-deficit syndrome, will remain contingent on the degree of preservation of muscarinic signaling, which itself may be unstable and vary between trait and state examinations. At the extreme end of muscarinic impairment, a deficit schizophrenia subpopulation is proposed with a primary and fixed muscarinic receptor hypofunction.
The genomic profile of bipolar disorder and schizophrenia overlap and both have a common dopaminergic intracellular signaling which is hypersensitive to various stressors. It is proposed that the concomitant muscarinic receptor upregulation differentiates the syndromes, being marked in bipolar disorder and rather less so in schizophrenia. From a behavioral point of view non-deficit syndromes and bipolar disorder appear most proximate and could be reclassified as a spectrum of affective psychosis or schizoaffective disorders. Because of a profound malfunction of the muscarinic receptor, the deficit subgroup cannot express a comparable stress response. None -theless, a convergent principle of psychotic features across psychiatric disorders is a relative monoaminergic-muscarinic imbalance in signal transduction.
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Majid Monajjemi and Fatemeh Mollaamin
Recently, powerful instruments for biomedical engineering research studies, including disease modeling, drug designing and nano-drug delivering, have been extremely investigated…
Abstract
Purpose
Recently, powerful instruments for biomedical engineering research studies, including disease modeling, drug designing and nano-drug delivering, have been extremely investigated by researchers. Particularly, investigation in various microfluidics techniques and novel biomedical approaches for microfluidic-based substrate have progressed in recent years, and therefore, various cell culture platforms have been manufactured for these types of approaches. These microinstruments, known as tissue chip platforms, mimic in vivo living tissue and exhibit more physiologically similar vitro models of human tissues. Using lab-on-a-chip technologies in vitro cell culturing quickly caused in optimized systems of tissues compared to static culture. These chipsets prepare cell culture media to mimic physiological reactions and behaviors.
Design/methodology/approach
The authors used the application of lab chip instruments as a versatile tool for point of health-care (PHC) applications, and the authors applied a current progress in various platforms toward biochip DNA sensors as an alternative to the general bio electrochemical sensors. Basically, optical sensing is related to the intercalation between glass surfaces containing biomolecules with fluorescence and, subsequently, its reflected light that arises from the characteristics of the chemical agents. Recently, various techniques using optical fiber have progressed significantly, and researchers apply highlighted remarks and future perspectives of these kinds of platforms for PHC applications.
Findings
The authors assembled several microfluidic chips through cell culture and immune-fluorescent, as well as using microscopy measurement and image analysis for RNA sequencing. By this work, several chip assemblies were fabricated, and the application of the fluidic routing mechanism enables us to provide chip-to-chip communication with a variety of tissue-on-a-chip. By lab-on-a-chip techniques, the authors exhibited that coating the cell membrane via poly-dopamine and collagen was the best cell membrane coating due to the monolayer growth and differentiation of the cell types during the differentiation period. The authors found the artificial membrane, through coating with Collagen-A, has improved the growth of mouse podocytes cells-5 compared with the fibronectin-coated membrane.
Originality/value
The authors could distinguish the differences across the patient cohort when they used a collagen-coated microfluidic chip. For instance, von Willebrand factor, a blood glycoprotein that promotes hemostasis, can be identified and measured through these type-coated microfluidic chips.
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Lu Zhang and Lydia Hanks
This study aims to investigate the joint effect of three factors – processing fluency, the individuals’ need for cognition (NFC) and mood – on consumer skepticism toward corporate…
Abstract
Purpose
This study aims to investigate the joint effect of three factors – processing fluency, the individuals’ need for cognition (NFC) and mood – on consumer skepticism toward corporate social responsibility (CSR) messages.
Design/Methodology/Approach
Study 1 uses a 2 (fluency: high versus low) × 2 (NFC: high versus low) design. In Study 2, a three-way interaction between fluency, NFC and mood was explored.
Findings
Individuals high in need for cognition responded more positively after reading a CSR message that is difficult to process. On the other hand, people low in NFC exhibited a higher level of skepticism toward CSR messages with low processing fluency. In addition, such an effect was moderated by mood. Positive mood (versus negative mood) increased dopamine levels, which further reduced skepticism.
Practical implications
Hospitality marketers should not simply assume that all consumers process information in the same fashion and, therefore, design their CSR message using the “one size fits all” strategy. It is critical for them to understand the importance of how to present the CSR messages to communicate with customers more effectively.
Originality/value
CSR has been increasingly used as a marketing tool by firms because of its positive effect on company reputation and customers’ purchase intentions. However, one of the greatest challenges corporate marketers are facing with regard to CSR programs is consumer skepticism. No prior research investigated the impact of processing fluency, individuals’ need for cognition and mood on consumer skepticism. This study fills this gap in the hospitality literature.
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Swaminathan Mani and Mridula Mishra
To provide an alternative, neuroscience perspective to enhance employee engagement in companies.
Abstract
Purpose
To provide an alternative, neuroscience perspective to enhance employee engagement in companies.
Design/methodology/approach
The authors have undertaken extensive literature review to identify the key neurotransmitters that enhances employee motivation. The paper list four neurochemicals - DOSE (Dopamine, Oxytocin, Serotonin and Endorphins) are called “angel chemicals” that enhance the overall well-being of people. The characteristics of these neurochemicals and their impact on employee engagement are discussed briefly in the paper. Care has been taken to ensure the language used in the paper is not medical terminologies but what is widely used in the business world - to make it relevant for HR managers and leaders in the Industry.
Findings
Dopamine (Mood elevator that enhances happiness and is associated with memory, learning, planning and productivity), Oxytocin (that enhances bonding, trust and empathy), Serotonin (that helps maintain emotional balance and enhances well-being) and Endorphins (boosts self-esteem and reduces anxiety) are all known to enhance productivity, improve collaboration, increase prosocial behavior, reduce stress and boost the overall well-being of the employees. These concepts are both the necessary goldilocks conditions and celebrated output of having highly engaged workforce. Many of the triggers for synthesizing DOSE in the body needs small modifications in the office environment and cost-effective interventions as shared in the paper. Companies have spent several hundred billion dollars on employee engagement initiatives with limited success. HR leaders now have an alternative, neuroscience perspective to consider as part of their overall employee engagement strategy.
Originality/value
This paper provides insights into this important concept of employee engagement from a neuroscience perspective. Leveraging DOSE to enhance employee engagement is a new concept that HR managers now can use to augment their employee engagement interventions to enhance the teams’ morale.
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Joan Carles Mico, Salvador Amigó, Antonio Caselles and Pantaleón D. Romero
The purpose of this paper is to investigate the body-mind problem from a mathematical invariance principle in relation to personality dynamics in the psychological and the…
Abstract
Purpose
The purpose of this paper is to investigate the body-mind problem from a mathematical invariance principle in relation to personality dynamics in the psychological and the biological levels of description.
Design/methodology/approach
The relationship between the two mentioned levels of description is provided by two mathematical models as follows: the response model and the bridge model. The response model (an integro-differential equation) is capable to reproduce the personality dynamics as a consequence of a determined stimulus. The invariance principle asserts that the response model can reproduce personality dynamics at the two levels of description. The bridge model (a second-order partial differential equation) can be deduced as a consequence of this principle: it provides the co-evolution of the general factor of personality (GFP) (mind), the it is an immediate early gene (c-fos) and D3 dopamine receptor gene (DRD3) gens and the glutamate neurotransmitter (body).
Findings
An application case is presented by setting up two experimental designs: a previous pilot AB pseudo-experimental design (AB) pseudo-experimental design with one subject and a subsequent ABC experimental design (ABC) experimental design with another subject. The stimulus used is the stimulant drug methylphenidate. The response and bridge models are validated with the outcomes of these experiments.
Originality/value
The mathematical approach here presented is based on a holistic personality model developed in the past few years: the unique trait personality theory, which claims for a single personality trait to understand the overall human personality: the GFP.
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