Search results

ß-thalassemia is a hereditary disorder due to mutation in the ß-globin gene on chromosome 11. Out of 200 known ß-globin gene chain mutations recognized, it is better to identify the most common mutation in specific regions and ethnicity for cost-effective molecular diagnosis of this disorder. Therefore, this study aims to practice multiplex-amplification refractory mutation system (ARMS) PCR on patients with thalassemia in Khyber Pakhtunkhwa (KP) to investigate the most common mutations in the ß-globin chain gene.

Twenty-two individuals (patients, their parents and non-affected siblings) with signed consent were studied from six consanguineous families of ß-thalassemia. Blood samples were collected for DNA isolation. For the detection of mutations in the ß-globin gene, ARMS-PCR was used. The amplicon was visualized through 2% Agarose Gel.

The most common mutations among different ethnic groups in the study area residents were Fr 8-9 (+G) and IVS 1-5 (G> C). The prominent enhancing factors for ß-thalassemia are inter-family marriages and lack of awareness.

Multiplex ARMS_PCR is the most valuable technique for assessing multiple mutations in a single reaction tube.

Due to extensively found ethnic and regional variations and a high rate of consanguinity, the Pashtun population has a great risk of mutations in their genome. Therefore, ARMS-PCR is a cost-effective mutational diagnostic strategy that can help to control disease burden.

Limited studies using ARMS-PCR for mutational analysis in the ß-globin gene are conducted. This study is unique as it targeted consanguineous families of KP Pakistan.

This paper aims to investigate the prepared modified alkyd and poly(ester-amide) (PEA) resins as antimicrobial and insecticide binders for surface coating applications.

Salicylic diethanolamine and 4-(N, N-dimethylamino) benzylidene glutamic acid were prepared and used as new sources of polyol and dibasic acid for PEA and alkyd resins, then confirmed by: acid value, FT-IR and 1H-NMR. The coating performance of the resins was determined using measurements of physico-mechanical properties. The biological and insecticide activities of the prepared resins were investigated.

The tests carried out revealed that the modified PEA and alkyd enhanced both phyisco-mechanical and chemical properties in addition to the biological and insecticide activities. The results of this paper illustrate that the introduction of salicylic diethanolamine and 4-(N, N-dimethylamino) benzylidene glutamic acid within the resin structure improved the film performance and enhanced the antimicrobial activity performance of PEA and alkyd resins.

The modified alkyd and PEA organic resins can be used as biocidal binders when incorporated into paint formulations for multiple surface applications, especially those that are exposed to several organisms.

Modified alkyd and PEA resins based on newly synthesized modifiers have a significant potential to be promising in the production and development of antimicrobial and insecticide paints, allowing them to function to restrict the spread of insects and microbial infection.

Education 4.0 (E 4.0) represents a new paradigm in the field of education, which emphasizes a student-centric approach that allows learners to access education anytime, anywhere, tailored to their individual needs through modern-day technologies. The purpose of the study was to unearth the critical success factors (CSFs) essential for the successful implementation of E 4.0.

The CSFs were unearthed using a literature review and further the interrelationships were analysed using multi-criteria decision making (MCDM) approach.

The study unearthed 15 CSFs for the successful implementation of E 4.0. The most important factor for the successful implementation of E 4.0 was personalized learning which was found to be the casual factor. The other causal CSFs were clear vision and leadership for E 4.0, stakeholder involvement, data analytics in teaching and learning, inter-disciplinary learning and blended learning environments. The effect factors were digital citizenship-based education, teacher training and development for E 4.0, supportive environment, curriculum redesign for E 4.0, open educational resources, digital technologies, formative assessments, infrastructure for E 4.0 and sustainability in education.

This is the first study which unearthed the CSFs and found the interrelationships among them, thus contributing to the theory of technology organization environment.

This study represented a pioneering effort in understanding the CSFs underpinning the successful adoption of E 4.0, paving the way for a more personalized, tech-savvy and effective education system.

This study aims to examine the impact of two dimensions of agile work practices (i.e. agile taskwork and agile teamwork) on team efficacy and creativity. Further, it examines the mediating effect of team efficacy in the relationship between two dimensions of agile work practices and team creativity.

The data were collected from 563 professionals working in 290 information technology (IT) companies in India using a self-reporting structured questionnaire. Partial least squares-structural equation modeling (PLS-SEM) was used to test the hypothesized model.

The results demonstrate that agile taskwork and agile teamwork positively impact team creativity and team efficacy, and team efficacy positively impacts team creativity. Furthermore, team efficacy partially mediates the impact of agile taskwork and agile teamwork on team creativity.

This study shows the importance of agile work practices and team efficacy to enhance team creativity. The research offers managers strategies to boost team creativity.

There is a dearth of research examining the distinct effects of agile taskwork and agile teamwork on team efficacy and team creativity. Also, this study is one of its kind that examines the mediating mechanisms that explain the effect of agile taskwork and agile teamwork on team creativity.

This paper aims to discuss the emergence of science, technology and innovation (STI) institutions in Indonesia during the Dutch East Indies colonial period in 1778–1941. The emergence of these institutions reflected the dynamics of science and technology development and innovation in that era.

This paper navigates a historiographical approach. Data collection techniques use “secondary data research,” with archival investigation published by official sources in the Dutch East Indies in the 18th and 19th centuries as well as other reference sources, and data analysis techniques use “supplementary analysis.”

This research indicates that the STI institution during the Dutch East Indies colonial period was formed to maximize the natural resources of the Dutch East Indies. The STI institution at that time was constructed as part of Buitenzorg’s Plantentuin the lands, plantations, solutions for health, astronomy, geology, forestry and culture.

The limitations of this research, as well as future research. Relying too much on “secondary data” is a limitation of this study. Therefore, it is necessary to collect primary data through in-depth interviews with historical scientists studying STIs in Indonesia in future research.

This study, to the best of the authors’ knowledge, considered the first study, reveals the dynamics of STI in Indonesia during the Dutch East Indies colonial era by examining the dynamics of the institution. In addition, this study succeeded in dividing five institutional STI clusters in the Dutch East Indies Colonial period 1778–1941, namely, units/institutions formed as part of Planuntungin te Buitenzorg; units/institutions formed based on plantations, initiated by private plantations to find solutions to the pests and diseases that attack their crops; units/institutions formed to seek solutions in the health sector; units/institutions formed based on astronomy, geology and forestry; and units/ institutions regarded as scientific councils/associations.

This study aims to empower cruise academia to assert their role as enablers, and potentially drivers, of sustainable, responsible and resilient cruise futures.

This contribution represents a synthesis and a critical reflection of cruise-related research-review literature over the last four decades, assessing its impact and potential in terms of influencing the evolution and future developments of cruise tourism.

Cruise research between the 1980s and the first decade of this century could be characterised as “ship-centric” and managerially focused. Over the last decade and up to the aftermath of the COVID-19 pandemic, cruise research has become increasingly “cruise-destination centric”, with sustainability emerging as a dominant theme. Diverging somewhat from the public and media emphasis on environmental concerns and risks, academic research tends to focus on the economic aspects of sustainability. Nonetheless, and despite aiming for practical relevance, cruise research tends to remain reactive and lags behind industry trends.

This paper proposes a shift from a “applied” to an “applicable” research paradigm, inspiring researchers to proactively shape the industry‘s future by embracing “what-ifs” in their thematic scope. Such a paradigm calls for a normativity-enriched methodological diversity, as well as the inclusion of transformational relevance as an indicator of research impact.

Public perceptions of cruise tourism have changed over the years, evolving from that of a promising holiday niche to a symbol of unsustainable mass tourism. In this context, cruise scholars are offered guidance for transcending the polarising debate of growth versus de-growth/limits while increasing the relevance and transformational impact of cruise scholarship.

这篇论文是对过去四十年来与邮轮旅游相关的研究评论文献的综述和批判性反思, 评估其在影响邮轮旅游的演变和未来发展方面的影响和潜力。

总体目标是增强邮轮学术界的能力, 使其能够在可持续、负责任和有弹性的邮轮未来发展中发挥促进者和潜在推动者的作用。

20 世纪 80 年代至本世纪头十年的邮轮研究可以说是 “以船为中心”, 以管理为重点。 在过去的十年中, 直到 COVID19 大流行之后, 邮轮研究越来越 “以邮轮目的地为中心”, 可持续发展成为主导主题。 与公众和媒体强调的环境问题和风险有些不同, 学术研究往往侧重于可持续发展的经济方面。 尽管如此, 邮轮研究尽管以实际相关性为目标, 但仍倾向于被动应对, 落后于行业发展趋。

本文提出了从 “应用 “研究范式向 “适用 “研究范式的转变, 激励研究人员通过在其主题范围内接受 “假设”, 积极塑造行业的未来。这种范式要求在方法上丰富规范性, 并将变革相关性作为衡量研究影响力的指标。

多年来, 公众对邮轮旅游的看法发生了变化, 从充满希望的度假小众旅游发展成为不可持续的大众旅游的象征。在此背景下, 为邮轮学者提供了指导, 以超越增长与去增长/限制的两极化争论, 同时提高邮轮学术研究的相关性和变革性影响。

Esta contribución representa una síntesis y una reflexión crítica de la literatura de investigación-revisión relacionada con los cruceros durante las últimas cuatro décadas, evaluando su impacto y potencial en términos de influencia sobre la evolución y futuros desarrollos del turismo de cruceros.

El objetivo general es capacitar al mundo académico de los cruceros para hacer valer su papel como facilitadores, y potencialmente impulsores, de futuros cruceros sostenibles, responsables y resilientes.

La investigación sobre cruceros entre los años 80 y la primera década de este siglo, podría caracterizarse como “centrada en el barco” y enfocada a la gestión. Durante la última década y hasta las secuelas de la pandemia de COVID19, la investigación sobre cruceros se ha vuelto cada vez más “centrada en los cruceros-destino”, con la sostenibilidad emergiendo como tema dominante. Apartándose un tanto del énfasis público y mediático en las preocupaciones y riesgos medioambientales, la investigación académica tiende a centrarse en los aspectos económicos de la sostenibilidad. No obstante, y a pesar de aspirar a la relevancia práctica, la investigación sobre cruceros tiende a seguir siendo reactiva y se queda rezagada con respecto a las tendencias del sector.

Este documento propone un cambio de un paradigma de investigación “aplicado” a otro “aplicable”, que inspire a los investigadores a configurar de forma proactiva el futuro de la industria, abarcando los “y si…” en su ámbito temático. Dicho paradigma exige una diversidad metodológica enriquecida por la normatividad, así como la inclusión de la relevancia transformadora como indicador del impacto de la investigación.

La percepción pública del turismo de cruceros ha cambiado a lo largo de los años, evolucionando desde la de un nicho vacacional prometedor a la de un símbolo del turismo de masas insostenible. En este contexto, se ofrece a los estudiosos de los cruceros una guía para trascender el polarizante debate de crecimiento frente a decrecimiento/límites, al tiempo que se aumenta la relevancia y el impacto transformador de los estudios sobre cruceros.

Within the scope of broadening participation and developing diverse talents in STEM leadership, this paper aims to deliver a research study that explores faculty leaders’ caring intelligence as STEM leadership intelligence. STEM leadership intelligence is the knowledge, skills, traits and aptitude essential to effective leadership in STEM education.

A previously developed STEM caring-oriented academic managerial leadership framework (SCAMLF) and a typology of STEM faculty leadership styles were used to thematically analyze the caring intelligence and leadership qualities of STEM faculty leaders. Interview transcripts of 18 STEM faculty leaders at Historically Black Colleges and Universities (HBCUs), provided by the Center for the Advancement of STEM Leadership (CASL), were used as data in this study.

The empirical evidence gained from this study highlighted important themes, descriptors and narratives for exploring caring intelligence and leadership intelligence of STEM faculty leadership in HBCUs.

Although the generalizability of the study is limited because of the sample size, STEM caring was found to be the most common dimension present in the reflections of participating STEM faculty leaders with diverse leadership styles. Implications for future research on STEM leadership intelligence were discussed.

Studying caring intelligence as a form of leadership intelligence provides a new and innovative means of assessing STEM leadership intelligence. Caring intelligence can be employed to predict the mindset, performance and behaviors of STEM faculty leaders.

This study aims to examine the research productivity of Pakistan Agricultural Research Council’s (PARC’s) researchers published during 2001–2020 by using scientometric indicators. The study explored the growth and collaborative trends along with authorship and institutional collaborative patterns at the national and international levels.

The study was conducted in four phases. Firstly, a search strategy was designed to retrieve reliable data sets. During the second phase, data from PARC research was retrieved from Scopus and Web of Science (WoS). In the third phase, the data were combined, and duplications were removed. Finally, the data were analysed using RStudio and VOSviewer.

The study identified 2,868 research publications from 16 communication channels spanning over the period of 2001–2020. The growth rate varied during the study period and the year 2020 was the most productive year of the organization. Most of the research was produced in multi-authorship and five authors were dominant. Pakistan Journal of Botany was the most preferred and cited source. Moreover, PARC research collaboration with Pakistani researchers was more than their international counterparts.

Like other research, this research has some limitations. For example, this research is based on secondary data extracted from WoS and Scopus databases, world-renowned online academic. However, researchers should keep in mind while interpreting the results of this study. Secondly, the research publications published by PARC researchers during 2001–2020 were considered. Finally, this research considered English language literature only.

The study’s key theoretical contribution is its strategy for merging WoS and Scopus in RStudio, while its findings could assist agriculture research stakeholders in identifying new areas of research, awards, promotions and identification of research gaps.

To the best of the author’s knowledge, this study is the first to use scientometric indicators to evaluate PARC’s research productivity. This detailed analysis provides a deeper understanding of PARC’s contribution to agriculture research and its potential implications.

Investment decisions hold immense significance for investors and eventually affect their portfolio performance. Investors are advised to weigh the costs and benefits associated with every decision in order to make rational investment decisions. However, behavioral finance research reveals that investors' choices often stem from a blend of economic, psychological and sociological factors, leading to irrationality. Moreover, environmental, social and corporate governance (ESG) factors, aligned with behavioral finance hypotheses, also sway opinions and stock prices. Hence, this study aims to identify how individual equity investors prioritize key determinants of investment decisions in the Indian stock market.

The current research gathered data from 391 individual equity investors through a structured questionnaire. Thereafter, a fuzzy analytic hierarchy process (F-AHP) was used to meet the purpose of the research.

Information availability, representative heuristics belonging to psychological factors and macroeconomic indicators falling under economic factors were discovered to be the three most prioritized criteria, whereas environmental issues within the realm of ESG factors, recommendations of brokers or investment consultants of sociological factors, and social issues belonging to ESG factors were found to be the least prioritized criteria, respectively.

Only active and experienced individual equity investors were surveyed in this study. Furthermore, with a sample size of 391 participants, the study was confined to individual equity investors in one nation, India.

This research has implications for individual investors, institutional investors, market regulators, corporations, financial advisors, portfolio managers, policymakers and society as a whole.

To the best of the authors' knowledge, no real attempt has been made to comprehend how active and experienced individual investors prioritize critical determinants of investment decisions by taking economic, psychological, sociological and ESG factors collectively under consideration.

Infrastructure forms a basis for the operations and sustainability of the modern society. This paper aims to recognize value creation from the infrastructure procurement ecosystem perspective to achieve those goals. The pursuit of enhancing value creation involves an examination of infrastructure procurement challenges, boundaries as well as boundary spanners that facilitate effective knowledge transfer and interaction.

The qualitative study is based on content analysis of 25 thematic interviews. Data was transcribed and coded via Atlas.ti software.

Infrastructure procurement value creation challenges appear complex and related to boundaries that hamper collaboration, coordination and knowledge sharing. Our results show that these boundaries locate within and between different levels of procurement ecosystem. Therefore, value creation in infrastructure procurement requires boundary spanners for leveraging knowledge sharing and interaction. Artifacts, discussion, processes and brokers as identified boundary spanners are strongly nested and interrelated in the industry. Special attention should be given to supporting individuals to act as brokers, since they play the key roles in trust building, culture steering and usage of other boundary spanners.

Promoting value creation in infrastructure procurement helps to achieve socio-economic development goals.

This study offers a unique perspective on value creation in the context of infrastructure by adopting an ecosystem lens and examining boundary crossing mechanisms. The results support future development of collaboration and knowledge sharing practices fostering procurement productivity.