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This study aims to investigate the effect of Lean Six Sigma elements on the Jordanian Pharmaceutical Manufacturing organizations’ business performance.

Data were collected from 120 managers out of about 300 managers by means of questionnaire. After confirming normality, validity and reliability of the study tool, correlation analysis was carried out, and then multiple regressions were used to test the hypotheses.

The results show that there is an agreement on high implementation of Lean Six Sigma variables among Jordanian Pharmaceutical Manufacturing organizations; there are strong relationships among Lean Six Sigma variables, except between non-utilized talent and transportation; there are strong relationships between Lean Six Sigma variables and business performance. All Lean Six Sigma variables have effect on business performance, except extra processing and waiting time.

This study was carried out on the pharmaceutical industry in Jordan, generalizing results of one industry and/or one country to other industries and/or countries may be questionable. Extending the analyses to other industries and countries represents future research opportunities.

Implementing Lean Six Sigma variables in all Jordanian Pharmaceutical Manufacturing organizations can improve their business performance; also, it can be applied to other manufacturing industry.

The aim of all organizations is to reduce waste, which leads to reserve the natural resources, which is considered as a corporate social responsibility.

Only few studies related to Lean or Six Sigma have been carried out in pharmaceutical industry in Jordan. Therefore, this study might be considered as an initiative study, which studies the effect of both Lean and Six Sigma on pharmaceutical industry in Jordan.