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The ageing process is often discussed as though it is unique to humans. However, it can be observed throughout the plant and animal kingdoms. In every species in which it occurs, the ageing process has common traits. It is a progressive, intrinsic, cumulative and deleterious process that eventually gives rise to physiological frailty, morbidity and death. Historically, biogerontology had a slow start but the last 10 years have seen exceptional progress in understanding both why and how ageing changes occur. As a result of this new knowledge, interventions that could produce longer, healthier human lives are close to becoming clinical realities. Unfortunately, the speed and scale of these advances is not well understood outside the relatively small community of biological gerontologists. This article reviews some of these advances for a non‐specialist audience, speculates on their potential impact and identifies current barriers to future progress.

Increased longevity is the success story of 20th‐century biomedicine, together with improvements in general living conditions, but it brings great challenges. Although many individuals do undergo what might be termed ‘successful ageing’, this is not a universal experience, for with older age comes a range of age‐related diseases and degenerations that can diminish, if not destroy, quality of life for some older individuals. Biogerontology is the study of the biology of ageing, a normal process but one that has the potential to contribute to age‐related disease. Its goal is to extend the proportion of a life that is healthy, an outcome that is desirable both at an individual and a societal level. One of the great insights from the last decade or more of biogerontology is the realisation that the ageing process is not a fixed, unchangeable process. Rather, it is controlled by genes and is open to experimental interventions that extend healthy lifespan, in species from microbes to mice. These findings have produced a sea change in the way the biogerontological community views ageing: not as a fixed, ‘inevitable’ process, but one where rates of ageing vary enormously according to genotype, and can be readily changed by interventions. This makes the biological process of ageing an attractive target both to understand, and target, age‐related conditions.

In this paper we present preliminary findings from a study of the social, ethical and cultural aspects of ageing science and medicine. The paper draws on a collaborative, ongoing project between life scientists and sociologists, funded by the Economic and Social Research Council's (ESRC) New Dynamics of Ageing Programme1 and the ESRC Centre for the Economic and Social Aspects of Genomics2. The sociological element of this project involves participant observation and interviews with expert scientists who specialise in ageing and age‐related diseases, both in the UK and the US, as well as interviews with sceptics of ageing science and medicine. There has been much critique of how ageing science is anti‐ageing, reinforcing the ageism prevalent in Western culture. Our specific objective in this paper is to suggest how biogerontology can contribute to the social inclusion of older people, particularly in relation to health care. We discuss how agesim is endemic to some aspects of health care, and go on to show how the ways that biogerontology is reconceptualising what it is to age, and to be old, can help reinclude ageing and the aged in health‐care education, policy and practice.

This review aims to focus on recent reported research work on the construction and function of different electrochemical DNA biosensors. It also describes different sensing materials, chemistries of immobilization probes, conditions of hybridization and principles of transducing and amplification strategies.

The human disease-related mutated genes or DNA sequence detection at low cost can be verified by the electrochemical-based biosensor. A range of different chemistries is used by the DNA-based electrochemical biosensors, out of which the interactions of nanoscale material with recognition layer and a solid electrode surface are most interesting. A diversity of advancements has been made in the field of electrochemical detection.

Some important aspects are also highlighted in this review, which can contribute in the creation of successful biosensing devices in the future.

This paper provides an updated review of construction and sensing technologies in the field of biosensing.

Women in medicine face barriers that hinder progress toward top leadership roles, and the industry remains plagued by the grand challenge of gender inequality. The purpose of this study was to explore how subtle and overt gender biases affect women physicians, physician leaders, researchers, and faculty working in academic health sciences environments and to further examine the association of these biases with workplace satisfaction. The study used a convergent mixed methods approach. Sampling from a list of medical schools in the United States, in conjunction with a list of each state's medical society, the authors analyzed the quantitative survey responses of 293 women in medicine. The authors conducted ordinary least squares multiple regression to assess the relationship of gender barriers on workplace satisfaction. Additionally, 132 of the 293 participants provided written open-ended responses that were explored using a qualitative content analysis methodology. The survey results showed that male culture, lack of sponsorship, lack of mentoring, and queen bee syndrome were associated with lower workplace satisfaction. The qualitative results provided illustrations of how participants experienced these biases. These results emphasize the obstacles that women face and highlight the detrimental nature of gender bias in medicine. The authors conclude by presenting concrete recommendations for managers endeavoring to improve the culture of gender equity and inclusivity.

According to current estimates, the prevalence of autism spectrum disorders (ASDs) ranges from 1 in 500 children to 1 in 150 children (Centers for Disease Control and Prevention/CDC, 2007; Desmon, 2007). In the past such disorders usually were not identified until a child was school-aged, but these disorders are now more likely to be diagnosed in affected individuals during the preschool years (McConachie, Le Couteur, & Honey, 2005; Rutter, 2006). For example, Mandell, Novak, and Zubritsky (2005) surveyed over 900 caregivers of children with ASDs and learned that on an average, children with autistic disorder were diagnosed at 3.1 years of age. These researchers also reported that children who exhibited such characteristics as severe language impairment, toe walking, hand flapping, and sustained unusual play behaviors were diagnosed earlier than children without these features.

How does downsizing affect long‐ and short‐term organizational performance? The present study aims to address this important question and attempts to extend previous research by examining the effect of both personnel and assets reduction on long‐ and short‐term firm performance.

The paper uses data collected through secondary sources on 196 firms traded on the Tel Aviv Stock Exchange (TASE) between 1992 and 2001.

Econometric analyses indicate the positive impact of a combination of downsizing strategies on short‐term performance, and the negative effect of this combination on long‐term performance and high‐tech industry performance is negatively related to assets and personnel cutbacks. Whereas downsizing affects the short‐term performance of larger and established companies positively, it generally affects long‐term performance inversely.

This study offers a first examination of the effects of simultaneous cutbacks in personnel and assets. This combined strategy goes further than dismissing employees, since layoffs are linked to the sale of such tangible assets as product lines or manufacturing facilities. By so doing, firms downscale their activities commensurate with the reduction in workforce and are less likely to generate excess workload on the remaining employees.

When the Library of Congress (LC) Subject Cataloging Division defended its decision last year to continue using “Gypsy” as its principal heading on the grounds that it was better known than the more correct “Rom,” it unwittingly demonstrated its own prejudices against my people.

How can organizations use strategic frames to develop support for illegal and stigmatized markets? Drawing on interviews, direct observation, and the analysis of 2,497 press releases, I show how pro-cannabis activists used distinct framing strategies at different stages of institutional development to negotiate the moral boundaries surrounding medical cannabis, diluting the market’s stigma in the process. Social movement organizations first established a moral (and legal) foothold for the market by framing cannabis as a palliative for the dying, respecting moral boundaries blocking widespread exchange. As market institutions emerged, activists extended this frame to include less serious conditions, making these boundaries permeable.

The paper is a review, for the general adult mental health practitioner, of the issues to consider when managing a mental health presentation of a person with intellectual disability (PWID). The paper aims to discuss these issues.

A neurodevelopmental model is outlined to assist practitioners in unravelling the wide range of potential factors relevant to intellectual disabilities (IDs). This includes an emphasis on complexity and interdisciplinary formulation within an individual’s context, and implications of the current policy changes.

In practice, managing the mental health of PWID can be challenging within usual mainstream services; there is more to consider than is usual for the general population.

The paper provides general mental health practitioners with a framework for a greater depth of understanding of the issues involved in the management of people with intellectual disability (ID). This includes discussion of the current policy context in ID, and some of its limitations.