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Purpose: Provide insights on how social entrepreneurship (SE) knowledge can be more effectively generated by universities through the entrepreneurial creation and effective management of a knowledge network centered on international collaborative research; illuminate how one such network has enabled Latin American researchers to advance the knowledge and practice frontiers in the hemisphere and globally. Methodology/Approach: Retrospective analysis of the two-decade evolution of the Social Enterprise Knowledge Network, a pioneering international research collaboration (IRC) of Ibero-American management schools. Findings: Documents factors and dynamics enabling the successful creation and operation of international knowledge networks. Analyzes the key mechanisms for capturing synergies in collaborative research. Identifies specific effectiveness determinants for successfully operating an international social enterprise knowledge generation network. Identifies multiple impacts of a knowledge generation network. Research Implications: Advances understanding of IRCs. Provides a model for assessing knowledge network multiple impacts. Identifies a series of future research opportunities and needs. Practical Implications: Provides operational guidance for researchers developing or operating collaborative international knowledge networks. Social Implications: Reveals the value of collaboration in international research and factors that contribute to effective collaboration. Originality/Value: Provides unique retrospective study of an IRC network operated by developing country schools of management. Expands the scope of recent comparative research on SE education to include a set of countries in Ibero-America. Documents an approach to assessing the impacts of a knowledge network. Identifies important areas for advancing future social enterprise research and teaching.