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1 – 10 of 383Aicha Benyahia‐Mostefaoui, Sabrine Louala and Myriem Lamri‐Senhadji
The present investigation was undertaken to study the potential effects of milk lipids compared to sardine oil on inflammation biomarkers and lipid peroxidation in…
Abstract
Purpose
The present investigation was undertaken to study the potential effects of milk lipids compared to sardine oil on inflammation biomarkers and lipid peroxidation in hypercholesterolemic rats. The paper aims to discuss these issues.
Design/methodology/approach
Male Wistar rats were fed 20 percent casein combined with 5 percent milk lipids or 5 percent sardine oil and 1 percent cholesterol for 28 days. A control group was fed a standard diet.
Findings
No significant difference in serum triacylglycerol (TG) was found in the milk lipids versus sardine oil and control. However, serum TG was reduced (1.7‐fold) with sardine oil compared with the control. Serum total cholesterol (TC) was, respectively, 3.6‐ and 2.5‐fold higher in milk lipids and sardine oil, respectively, compared with control. Compared to sardine oil, TC value was 1.4‐fold higher in the milk lipid. Serum C‐reactive protein (CRP) was elevated (eight‐ and 33‐fold) in the milk lipid and sardine oil compared to control, respectively. However, CRP value was four‐fold lower in milk lipids than those in sardine oil. Compared to sardine oil, iron value was two‐fold higher in milk lipids versus sardine oil. Malondialdehyde content of red blood cell, heart and brain were decreased in milk lipids versus sardine oil (p<0.05). Hydroperoxydes contents in milk lipids were also lower in heart and aorta compared to sardine oil and control (p<0.05).
Originality/value
Milk lipids compared to sardine oil does not modulate the hypercholesterolemia but decreases inflammation biomarkers and seems to protect efficiency of some tissues against the cytotoxic action and oxidative stress of cholesterol enriched diet.
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Sherazed Hamza-Reguig, Nabila Boukhari Benahmed Daidj, Sabrine Louala, Ahmed Boualga and Myriem Lamri-Senhadji
The purpose of this study was to investigate the impact of replacing two different fats on dyslipidemia, glycemic balance and adipose tissue redox status in obese rats.
Abstract
Purpose
The purpose of this study was to investigate the impact of replacing two different fats on dyslipidemia, glycemic balance and adipose tissue redox status in obese rats.
Design/methodology/approach
Obesity was induced by feeding a high-mutton-fat diet during three months. An experimental group (n = 24) was divided into two groups that were fed during one month, 20 per cent of margarine or sardine oil. At Day 30, six rats from each group were sacrificed and the remaining rats were then subjected to a change in diet for one month: margarine was replaced by sardine oil and inversely, and then the rats were sacrificed. Three other groups (n = 6), each fed during two months, 20 per cent of margarine, sardine oil or mutton fat, served as controls.
Findings
Substitution of sardine oil by margarine compared to control sardine oil had increased triacylglycerols (TGs), glycosylated hemoglobin (HbA1c) and isoprostanes (IsoPs) values, but decreased thiobarbituric acid reactive substances (TBARS) and superoxide dismutase activity. Replacing margarine by sardine oil compared to control margarine reduced total cholesterol, TG, HbA1c, TBARS and IsoP contents but enhanced glutathione reductase and peroxidase activities. Nevertheless, comparing with the mutton fat, the two substitutions had improved glycemic and lipidic abnormalities and attenuated lipoperoxidation by enhancing enzymatic antioxidant defense. These favorable effects were better when margarine was replaced by sardine oil.
Originality/value
Substituting margarine with sardine oil seems to attenuate beneficial cardiometabolic risk markers associated to obesity and potentiate efficiency adipose tissue against the oxidative stress induced by the obesogenic diet.
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In October, 1908, a report was issued by the Medical Officer of Health for the City of London relating to the unsatisfactory manner in which soda water was manufactured at that…
Abstract
In October, 1908, a report was issued by the Medical Officer of Health for the City of London relating to the unsatisfactory manner in which soda water was manufactured at that time in the London district, and to the means that had been used after official enquiry to better the methods of manufacture. The circumstances were referred to in this Journal for November, 1908. It will be remembered that at the time reputable members of the trade readily agreed that they should be bound by certain regulations. These regulations had been drawn up by the Medical Officer of Health for the City of London and related to inspection of premises and examination of plant, water, and materials. As a proof that they had complied with the regulations a certificate was issued to each firm by their trade society, “The London Bottle Exchange and Mineral Water Trade Protection Society, Limited.” This certificate was submitted to and passed by the Medical Officer of Health for the City of London before issue. The arrangement, though good in conception, appears to be faulty in design, and it is desirable, therefore, to offer some criticism.
There is an old saying to the effect that every one is destined to eat a peck of dirt before he dies. So much is probably inevitable, but by taking pains in the selection of our…
Abstract
There is an old saying to the effect that every one is destined to eat a peck of dirt before he dies. So much is probably inevitable, but by taking pains in the selection of our milkmen, butchers, bakers, and other purveyors, by refusing to buy jams, preserves, potted meats, and pickles manufactured by other than reputable firms, and above all by giving support to the various movements which have for their object the improvement of the law relating to adulteration of food, we can at least see that we are called upon to swallow no more than the maximum provided by the adage.
HadjMostefa Khelladi, Djamil Krouf and Nawal Taleb-Dida
This paper aims to study the effect of green lemon zest combined with sardine proteins in diabetic hypertensive rats (DHRs).
Abstract
Purpose
This paper aims to study the effect of green lemon zest combined with sardine proteins in diabetic hypertensive rats (DHRs).
Design/methodology/approach
Male Wistar rats (n = 30) weighing 250 ± 10 g were divided into five groups. The first group consumed a diet containing 20 per cent casein (C). The other four groups are rendered diabetic by intraperitoneal injection of streptozotocin (40 mg/kg body weight), then hypertensive by subcutaneous implantation controlled time-release pellet containing ouabain (0.25 mg/pellet). One untreated group (DHR) consumed 20 per cent casein and the three other groups consumed the same diet supplemented with 2 per cent green lemon zest (DHR-lz), or with 20 per cent of sardine protein (group DHR-sp) or with the combination of both sardine proteins and green lemon zest (group DHR-sp + lz).
Findings
DHRs feeding on the combination of both sardine protein (sp) and lemon zest (lz) induced a significant decrease of diastolic blood pressure and heart rates values compared with DHR (p < 0.05). The HDLC values were increased by +55 per cent in DHR-sp + lz compared with DHR group. Moreover, plasma non-HDLC concentrations were decreased significantly compared to DHR, DHR-lz, DHR-sp and C groups. In DHR-sp + lzvs DHR group, TBARS values were decreased by −25 per cent in the liver. Moreover, kidney TBARS were significantly reduced by −66, −51, −65 and −67 per cent compared with C, DHR, DHR-lz and DHR-sp, respectively.
Originality/value
These results suggest that consumption of green lemon zest combined with sardine proteins can reduce blood pressure and tissue oxidative damage and, therefore, help to prevent cardiovascular complications in hypertensive diabetic patients.
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Sherazed Hamza‐Reguig, Sabrine Louala, Ahmed Boualga and Myriem Y Lamri‐Senhadji
The purpose of this paper was to evaluate the effect of sardine protein on the redox status in rats fed a cholesterol‐rich diet.
Abstract
Purpose
The purpose of this paper was to evaluate the effect of sardine protein on the redox status in rats fed a cholesterol‐rich diet.
Design/methodology/approach
Hypercholesterolemic rats were divided into two groups fed diets enriched with cholesterol and containing 20 percent of sardine proteins (SPc) or casein (CASc) for 28 days. A control group was fed a standard diet (CAS).
Findings
After 28 days of experiment, no significant difference in serum total cholesterol triacylglycerols and uric acid was found with the three diets. Serum albumin content was, respectively, 2‐fold higher in SPc than those in CASc group. Compared to CAS, this value was 1.3‐fold lower in CASc group. In liver and heart, lipid peroxidation was 1.7‐ and 2‐fold lower in SPc compared with CASc and CAS, respectively. In red blood cells and epididymal fat, superoxide dismutase activity was, respectively, 1.3‐and 3‐fold higher in SPc compared to CASc. Epididymal fat and heart catalase activity were, respectively, elevated (+50 and +79 percent) in SPc than in CASc. Sardine protein decreased nitric oxide levels in heart and epididymal fat (twofold) compared to CASc but compared to control group, nitric oxide value was higher in epididymal fat (2‐fold) and liver (3‐fold).
Originality/value
Sardine protein exerts a beneficial action against oxidative stress caused by dietary cholesterol specifically in the heart by reducing lipid peroxidation and enhancing catalase activity.
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Souhila Benomar, Sanaa Yahia, Faiza Dehiba, Natalia Guillen, Maria Jesús Rodriguez-Yoldi, Jesús Osada and Ahmed Boualga
– The purpose of this study was to evaluate the antioxidant and hypocholesterolemic activities of sardine and bogue protein hydrolysates in cholesterol-fed rats.
Abstract
Purpose
The purpose of this study was to evaluate the antioxidant and hypocholesterolemic activities of sardine and bogue protein hydrolysates in cholesterol-fed rats.
Design/methodology/approach
In total, 18 male Wistar rats (220 ± 10 g) fed 20 per cent casein, 1 per cent cholesterol and 0.5 per cent cholic acid were divided into three groups and received a daily gavage of 250 mg of sardine (SPH) or bogue (BPH) protein hydrolysates for 30 days. The third group, named control group (CG), received in the same conditions water. Lipoproteins were fractionated by size-exclusion fast protein liquid chromatography, and serum lipids, apolipoproteins and lipoproteins were assayed.
Findings
In SPH and BPH groups, serum total cholesterol concentrations were −66 per cent lower than in CG. This corresponded to the decreased very low-density lipoprotein-C in the former groups. Moreover, BPH treatment reduced low-density lipoprotein-C compared with CG and SPH groups. Compared with CG, serum phospholipids were reduced by SPH and BPH. Furthermore, BPH increased significantly APOA4 and sphingomyelin but lowered phosphatidylcholine. In the latter group, serum lecithin cholesterol acyltransferase activity was +23 per cent higher, but with SPH, this activity was −35 per cent reduced compared with CG. Apolipoprotein A-I contents were similar in the three groups. Compared with CG, hydroperoxide and lipid peroxidation contents in serum and lipoprotein fractions were reduced by SPH and BPH. Compared with CG, serum superoxide dismutase and glutathione peroxidase activities were increased in the treated groups, particularly in the BPH group.
Originality/value
These results suggest that sardine protein hydrolysates and particularly those of bogue could be a very useful natural compound to prevent hypercholesterolemia by both improving the lipid profile and modulating oxidative stress in cholesterol-fed rats.
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No milk to be sold from newly‐calved cows, nor until three days after the calf has been removed.