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Article
Publication date: 28 October 2022

Yaser Khajebishak, Sadra Madani, Amir Hossein Faghfouri, Ali Soleimani, Sara Ilaei, Said Peyrovi and Laleh Payahoo

Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels…

Abstract

Purpose

Meteorin like-peptide (Metrnl) modulates energy hemostasis and relieves inflammation and oxidative stress. This study aims to investigate the relationship between Metrnl levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in obese type 2 diabetic patients.

Design/methodology/approach

This analytical cross-sectional study was carried out between August 2020 and March 2021on 93 people (n = 32 obese type 2 diabetic patients, n = 31 healthy obese, n = 30 healthy normal weight). Serum Metrnl levels were measured by enzyme-linked immunosorbent assay. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde and total antioxidant capacity were measured using standard methods. Body composition was assessed by bioelectrical impedance analysis. p-Value less than 0.05 was considered significant.

Findings

Serum Metrnl levels were lower in obese diabetic patients than in healthy normal-weight subjects (82.5 [72.4–94.5] ng/mL compared to 154 [129–189] ng/mL). The difference in Metrnl levels between the two groups was significant (p < 0.001). The difference in Metrnl levels between the two groups was significant. Moreover, a significant correlation between Metrnl level and both TNF-a and hs-CRP was detected (p = 0.006 and p < 0.001, respectively) and the correlation between Metrnl and IL-6 was borderline (p = 0.051). A negative correlation was revealed between Metrnl level and anthropometric measurements and body composition (p < 0.05) with the exception of fat-free mass and skeletal muscle mass.

Originality/value

To discover sufficient evidence for the therapeutic function of Metrnl and its use as a prognostic biomarker in the management of type 2 diabetes mellitus, future clinical studies are needed to highlight other factors influencing Metrnl serum levels.

Details

Nutrition & Food Science, vol. 53 no. 5
Type: Research Article
ISSN: 0034-6659

Keywords

Article
Publication date: 22 December 2020

Nahideh Rezaei, Rana Najjari, Arsalan Nezhadfard and Rahmat Mohammadzadeh

The purpose of this paper aims at the spatial analysis of the Rastas dealing with the wool market to revise the production resulting in a recreation of spaces and the pathways…

Abstract

Purpose

The purpose of this paper aims at the spatial analysis of the Rastas dealing with the wool market to revise the production resulting in a recreation of spaces and the pathways based on its high economic–commercial role.

Design/methodology/approach

Secondary resources and direct observations through field research were the two critical methodological steps for this paper based on phenomenology and qualitative approaches.

Findings

The results represent that the usage of past experiences is the most effective solutions for activities relying on manufacturing inside the workshops leading to improvement in functional objectives of Bazaar. Integration between diverse institutions, precise planning regarding the creation and restoration of past and new jobs and organizing the exhibition of recreational spaces contributing to development regarding public attraction and strengthening the spatial relationships between production, representation and service. Indeed these mentioned steps will provide multifunctional space with a priority of production and reproduction useful on a recreation of urban life.

Originality/value

This study fulfils to examine the important of the bazaar (Iranian market) and recreate its manufacturing, service and economic processes.

Details

Property Management, vol. 39 no. 2
Type: Research Article
ISSN: 0263-7472

Keywords

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