Search results

Bisphosphonate (BP) medications can be applied to prohibit the damage of bone density and the remedy of bone illnesses such as osteoporosis. As the metal chelating of phosphonate groups are nearby large with six O atoms possessing the high negative charge, these compounds are active toward producing the chelated complexes through drug design method. BP agents have attracted much attention for the clinical treatment of some skeletal diseases depicted by enhancing of osteoclast-mediated bone resorption.

In this work, it has been accomplished the CAM-B3LYP/6–311+G(d, p)/LANL2DZ to estimate the susceptibility of SWCNT for adsorbing alendronate, ibandronate, neridronate and pamidronate chelated to two metal cations of 2Mg²⁺, 2Ca²⁺, 2Sr²⁺ through nuclear magnetic resonance and thermodynamic parameters. Therefore, the data has explained that the feasibility of using SWCNT and BP agents becomes the norm in metal chelating of drug delivery system which has been selected through alendronate → 2X, ibandronate → 2X, neridronate → 2X and pamidronate → 2X (X = Mg²⁺/Ca²⁺/Sr²⁺) complexes.

The thermodynamic results have exhibited that the substitution of 2Ca²⁺ cation by 2Sr²⁺ cation in the structure of bioactive glasses can be efficient for treating vertebral complex fractures. However, it has been observed the most fluctuation in the Gibbs free energy for BPs → 2Sr²⁺ at 300 K. Furthermore, Monte Carlo simulation has resulted by increasing the dielectric constant in the aqueous medium can enhance the stability and efficiency of BP drugs for preventing the loss of bone density and treating the osteoporosis.

According to this research, by incorporation of chelated 2Mg²⁺, 2Ca²⁺ and 2Sr²⁺ cations to BP drugs adsorbed onto (5, 5) armchair SWCNT, the network compaction would increase owing to the larger atomic radius of Sr²⁺ cation rather than Ca²⁺ and Mg²⁺, respectively.

This study aims to numerically scrutinize the entropy generation minimization and mixed convective heat transfer of multi-walled carbon nanotubes–Fe₃O₄/water hybrid nanofluid flow in a lid-driven square enclosure with heat generation in the presence of a porous layer on inner surfaces, considering local thermal non-equilibrium (LTNE) approach and the non-Darcy flow model.

The dimensionless governing equations for hybrid nanofluid and solid phases are solved by applying the finite volume method and semi-implicit method for pressure-linked equations algorithm.

The roles of the internal heat generation in the porous layer, LTNE model and nanoparticles volume fraction on mixed convection phenomenon and entropy generation are introduced for lid-driven cavity hybrid nanofluid flow. Based on the investigation of entropy generation and heat transfer, the minimum total entropy generation and average Nusselt numbers are found at 1 ≤ Ri ≤ 10 where the effect of the forced and free convection flow directions being opposite each other is very significant. When considering various nanoparticle volume fractions, it becomes evident that the minimum entropy generation occurs in the case of φ = 0.1%. The outcomes of LTNE number reveal the operating parameters in which thermal equilibrium occurs between hybrid nanofluid and solid phases.

The analysis of entropy generation under various shear and buoyancy forces plays a significant role in the suitable thermal design and optimization of mixed convective heat transfer applications. This research significantly contributes to the optimization of design and the advancement of innovative solutions across diverse engineering disciplines, such as packed-bed thermal energy storage and thermal insulation.

The modern day has seen an increase in the prevalence of the improvement of high-performance thermal systems for the enhancement of heat transmission. Numerous studies and research projects have been carried out to acquire an understanding of heat transport performance for their functional application to heat conveyance augmentation. The idea of this study is to inspect the entropy production in Darcy-Forchheimer Ree-Eyring nanofluid containing bioconvection flow toward a stretching surface is the topic of discussion in this paper. It is also important to take into account the influence of gravitational forces, double stratification, heat source–sink and thermal radiation. In light of the second rule of thermodynamics, a model of the generation of total entropy is presented.

Incorporating boundary layer assumptions allows one to derive the governing system of partial differential equations. The dimensional flow model is transformed into a non-dimensional representation by applying the appropriate transformations. To deal with dimensionless flow expressions, the built-in shooting method and the BVP4c code in the Matlab software are used. Graphical analysis is performed on the data to investigate the variation in velocity, temperature, concentration, motile microorganisms, Bejan number and entropy production concerning the involved parameters.

The authors have analytically assessed the impact of Darcy Forchheimer's flow of nanofluid due to a spinning disc with slip conditions and microorganisms. The modeled equations are reset into the non-dimensional form of ordinary differential equations. Which are further solved through the BVP4c approach. The results are presented in the form of tables and figures for velocity, mass, energy and motile microbe profiles. The key conclusions are: The rate of skin friction incessantly reduces with the variation of the Weissenberg number, porosity parameter and Forchheimer number. The rising values of the Prandtl number reduce the energy transmission rate while accelerating the mass transfer rate. Similarly, the effect of Nb (Brownian motion) enhances the energy and mass transfer rates. The rate of augments with the flourishing values of bioconvection Lewis and Peclet number. The factor of concentration of microorganisms is reported to have a diminishing effect on the profile. The velocity, energy and entropy generation enhance with the rising values of the Weissenberg number.

According to the findings of the study, a slip flow of Ree-Eyring nanofluid was observed in the presence of entropy production and heat sources/sinks. There are features when the implementations of Darcy–Forchheimer come into play. In addition to that, double stratification with chemical reaction characteristics is presented as a new feature. The flow was caused by the stretching sheet. It has been brought to people's attention that although there are some investigations accessible on the flow of Ree-Eyring nanofluid with double stratification, they are not presented. This research draws attention to a previously unexplored topic and demonstrates a successful attempt to construct a model with distinctive characteristics.

The entropy and thermal behavior analyses of non-Newtonian nanofluid double-diffusive natural convection inside complex domains may captivate a bunch of scholars’ attention because of the potential utilizations that they possess in modern industries, for example, heat exchangers, solar energy collectors and cooling of electronic apparatuses. This study aims to investigate the second law and thermal behavior of non-Newtonian double-diffusive natural convection (DDNC) of Al₂O₃-H₂O nanofluid within a C-shaped cavity emplacing two hot baffles and impacted by a magnetic field.

For the governing equations of the complicated and practical system with all considered parameters to be solved via a formidable numerical approach, the finite element method acts as an approach to achieving the desired solution. This method allows us to gain a detailed solution to the studied geometry.

This investigation has been executed for the considered parameters of range, such as power-law index, baffle length, Lewis number, buoyancy ratio, Hartmann number and Rayleigh number. The main results reveal that isothermal and concentration lines are significantly more distorted, indicating intensified concentration and temperature distributions because of the growth of baffle length (L). Nu_ave decreases by 8.4% and 0.8% while it enhances by 49.86% and 33.87%, respectively, because of growth in the L from 0.1 to 0.2 and 0.2 to 0.3.

Such a comprehensive study on the second law and thermal behavior of DDNC of Al₂O₃-H₂O nanofluid within a C-shaped cavity emplacing two hot baffles and impacted by magnetic field has not yet been carried out.

The purpose of this study is a numerical simulation and an analytical analysis about the low-velocity impact on a functionally graded porous plate with porosity distribution in the thickness direction. In this article, polymethyl methacrylate is used for matrix, and single-walled carbon nanotube (CNTs) (10,10) with consideration agglomeration sizes and lumping of CNT inside the agglomerations is applied for reinforcement.

In analytical formulation, the non-linear Hertz contact law is applied for interaction between projectile and plate surface. High-order shear deformation plate theory is developed, and energy of the system for impactor and plate is written. The governing equations are derived using Ritz method and Lagrange equations and are solved using the fourth-order Runge–Kutta method. Also, ABAQUS finite element model of functionally graded porous plate with all edges simply supported and reinforced by CNT under low-velocity impact is simulated and is compared with those is achieved in the present analytical approach.

In parametric studies, the influence of porosity distribution patterns include uniform, non-uniform symmetric and non-uniform asymmetric on the histories of contact force and impactor displacement of simply supported plate reinforced by CNT are presented. Eventually, the effects of porosity coefficient, impactor initial velocity, impactor radius and CNTs lumping inside agglomerations for non-uniform symmetric distribution patterns are discussed in impact event in detail.

In this paper, the effect of combination of polymethyl methacrylate and CNTs with consideration agglomeration sizes and lumping of CNTs inside the agglomerations in the form of a functionally graded porous plate is studied in the problem of low-velocity impact analysis.

In many of today’s manufacturing industries, such as automobile, aerospace, defence, die and mould making, medical and electrical discharge machining (EDM) has emerged as an effective material removal process. In this process, a series of discontinuous electric discharges is used for removing material from the workpiece in the form of craters generating a replica of the tool into the workpiece in a dielectric environment. Appropriate selection of the tool electrode material and combination of input parameters is an important requirement for performance enhancement of an EDM process. This paper aims to optimize an EDM process using single-valued neutrosophic grey relational analysis using Cu-multi-walled carbon nanotube (Cu-MWCNT) composite tool electrode.

This paper proposes the application of grey relational analysis (GRA) in a single-valued neutrosophic fuzzy environment to identify the optimal parametric intermix of an EDM process while considering Cu-MWCNT composite as the tool electrode material. Based on Taguchi’s L9 orthogonal array, nine experiments are conducted at varying combinations of four EDM parameters, i.e. pulse-on time, duty factor, discharge current and gap voltage, with subsequent measurement of two responses, i.e. material removal rate (MRR) and tool wear rate (TWR). The electrodeposition process is used to fabricate the Cu-MWCNT composite tool.

It is noticed that both the responses would be simultaneously optimized at higher levels of pulse-on time (38 µs) and duty factor (8), moderate level of discharge current (5 A) and lower level of gap voltage (30 V). During bi-objective optimization (maximization of MRR and minimization of TWR) of the said EDM process, the achieved values of MRR and TWR are 243.74 mm³/min and 0.001034 g/min, respectively.

Keeping in mind the type of response under consideration, their measured values for each of the EDM experiments are expressed in terms of linguistic variables which are subsequently converted into single-valued neutrosophic numbers. Integration of GRA with single-valued neutrosophic sets would help in optimizing the said EDM process with the Cu-MWCNT composite tool while simultaneously considering truth-membership, indeterminacy membership and falsity-membership degrees in a human-centric uncertain decision-making environment.

Nonlinear mixed-convective entropy optimized the flow of hyperbolic-tangent nanofluid (HTN) with magnetohydrodynamics (MHD) process is considered over a vertical slendering surface. The impression of activation energy is incorporated in the modeling with the significance of nonlinear radiation, dissipative-function, heat generation/consumption connection and Joule heating. Research in this area has practical applications in the design of efficient heat exchangers, thermal management systems or nanomaterial-based devices.

Suitable set of variables is introduced to transform the PDEs (Partial differential equations) system into required ODEs (Ordinary differential equations) system. The transformed ODEs system is then solved numerically via finite difference method. Graphical artworks are made to predict the control of applicable transport parameters on surface entropy, Bejan number, Sherwood number, skin-friction, Nusselt number, temperature, velocity and concentration fields.

It is noticed from present numerical examination that Bejan number aggravates for improved estimations of concentration-difference parameter a_2, Eckert number E_c, thermal ratio parameter ?_w and radiation parameter R_d, whereas surface entropy condenses for flow performance index n, temperature-difference parameter a_1, thermodiffusion parameter N_t and mixed convection parameter ?. Sherwood number is enriched with the amplification of pedesis-motion parameter N_b, while opposite development is perceived for thermodiffusion parameter. Lastly, outcomes are matched with formerly published data to authenticate the present numerical investigation.

To the best of the authors' knowledge, no investigation has been reported yet that explains the entropic behavior with activation energy in the flowing of hyperbolic-tangent mixed-convective nanomaterial due to a vertical slendering surface.

Thermo-magnetic convective flow analysis under the impact of thermal radiation for heat and entropy generation phenomena is an active research field for understanding the efficiency of thermodynamic systems in various engineering sectors. This study aims to examine the characteristics of convective heat transport and entropy generation within an inverted T-shaped porous enclosure saturated with a hybrid nanofluid under the influence of thermal radiation and magnetic field.

The mathematical model incorporates the Darcy-Forchheimer-Brinkmann model and considers thermal radiation in the energy balance equation. The complete mathematical model has been numerically simulated through the penalty finite element approach at varying values of flow parameters, such as Rayleigh number (Ra), Hartmann number (Ha), Darcy number (Da), radiation parameter (Rd) and porosity value (e). Furthermore, the graphical results for energy variation have been monitored through the energy-flux vector, whereas the entropy generation along with its individual components, namely, entropy generation due to heat transfer, fluid friction and magnetic field, are also presented. Furthermore, the results of the Bejan number for each component are also discussed in detail. Additionally, the concept of ecological coefficient of performance (ECOP) has also been included to analyse the thermal efficiency of the model.

The graphical analysis of results indicates that higher values of Ra, Da, e and Rd enhance the convective heat transport and entropy generation phenomena more rapidly. However, increasing Ha values have a detrimental effect due to the increasing impact of magnetic forces. Furthermore, the ECOP result suggests that the rising value of Da, e and Rd at smaller Ra show a maximum thermal efficiency of the mathematical model, which further declines as the Ra increases. Conversely, the thermal efficiency of the model improves with increasing Ha value, showing an opposite trend in ECOP.

Such complex porous enclosures have practical applications in engineering and science, including areas like solar power collectors, heat exchangers and electronic equipment. Furthermore, the present study of entropy generation would play a vital role in optimizing system performance, improving energy efficiency and promoting sustainable engineering practices during the natural convection process.

To the best of the authors’ knowledge, this study is the first ever attempted detailed investigation of heat transfer and entropy generation phenomena flow parameter ranges in an inverted T-shaped porous enclosure under a uniform magnetic field and thermal radiation.

This review provides an overview of recent advances in electrochemical sensors for analyte detection in saliva, highlighting their potential applications in diagnostics and health care. The purpose of this paper is to summarize the current state of the field, identify challenges and limitations and discuss future prospects for the development of saliva-based electrochemical sensors.

The paper reviews relevant literature and research articles to examine the latest developments in electrochemical sensing technologies for saliva analysis. It explores the use of various electrode materials, including carbon nanomaterial, metal nanoparticles and conducting polymers, as well as the integration of microfluidics, lab-on-a-chip (LOC) devices and wearable/implantable technologies. The design and fabrication methodologies used in these sensors are discussed, along with sample preparation techniques and biorecognition elements for enhancing sensor performance.

Electrochemical sensors for salivary analyte detection have demonstrated excellent potential for noninvasive, rapid and cost-effective diagnostics. Recent advancements have resulted in improved sensor selectivity, stability, sensitivity and compatibility with complex saliva samples. Integration with microfluidics and LOC technologies has shown promise in enhancing sensor efficiency and accuracy. In addition, wearable and implantable sensors enable continuous, real-time monitoring of salivary analytes, opening new avenues for personalized health care and disease management.

This review presents an up-to-date overview of electrochemical sensors for analyte detection in saliva, offering insights into their design, fabrication and performance. It highlights the originality and value of integrating electrochemical sensing with microfluidics, wearable/implantable technologies and point-of-care testing platforms. The review also identifies challenges and limitations, such as interference from other saliva components and the need for improved stability and reproducibility. Future prospects include the development of novel microfluidic devices, advanced materials and user-friendly diagnostic devices to unlock the full potential of saliva-based electrochemical sensing in clinical practice.

The need for precise synthesis of customized designs has resulted in the development of advanced coating processes for modern nanomaterials. Achieving accuracy in these processes requires a deep understanding of thermophysical behavior, rheology and complex chemical reactions. The manufacturing flow processes for these coatings are intricate and involve heat and mass transfer phenomena. Magnetic nanoparticles are being used to create intelligent coatings that can be externally manipulated, making them highly desirable. In this study, a Keller box calculation is used to investigate the flow of a coating nanofluid containing a viscoelastic polymer over a circular cylinder.

The rheology of the coating polymer nanofluid is described using the viscoelastic model, while the effects of nanoscale are accounted for by using Buongiorno’s two-component model. The nonlinear PDEs are transformed into dimensionless PDEs via a nonsimilar transformation. The dimensionless PDEs are then solved using the Keller box method.

The transport phenomena are analyzed through a comprehensive parametric study that investigates the effects of various emerging parameters, including thermal radiation, Biot number, Eckert number, Brownian motion, magnetic field and thermophoresis. The results of the numerical analysis, such as the physical variables and flow field, are presented graphically. The momentum boundary layer thickness of the viscoelastic polymer nanofluid decreases as fluid parameter increases. An increase in mixed convection parameter leads to a rise in the Nusselt number. The enhancement of the Brinkman number and Biot number results in an increase in the total entropy generation of the viscoelastic polymer nanofluid.

Intelligent materials rely heavily on the critical characteristic of viscoelasticity, which displays both viscous and elastic effects. Viscoelastic models provide a comprehensive framework for capturing a range of polymeric characteristics, such as stress relaxation, retardation, stretching and molecular reorientation. Consequently, they are a valuable tool in smart coating technologies, as well as in various applications like supercapacitor electrodes, solar collector receivers and power generation. This study has practical applications in the field of coating engineering components that use smart magnetic nanofluids. The results of this research can be used to analyze the dimensions of velocity profiles, heat and mass transfer, which are important factors in coating engineering. The study is a valuable contribution to the literature because it takes into account Joule heating, nonlinear convection and viscous dissipation effects, which have a significant impact on the thermofluid transport characteristics of the coating.

The momentum boundary layer thickness of the viscoelastic polymer nanofluid decreases as the fluid parameter increases. An increase in the mixed convection parameter leads to a rise in the Nusselt number. The enhancement of the Brinkman number and Biot number results in an increase in the total entropy generation of the viscoelastic polymer nanofluid. Increasing the strength of the magnetic field promotes an increase in the density of the streamlines. An increase in the mixed convection parameter results in a decrease in the isotherms and isoconcentration.