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In electrochemotherapy, flexible electrodes, composed by an array of needles, are applied to human tissues to treat large surface tumors. The positioning of the needles in the tissue depends on the surface curvature. The parallel needle case is preferred, as their relative inclinations strongly affect the actual distribution of electric field. Nevertheless, in some case, small inclinations are unavoidable. The purpose of this paper is to study the electric field distribution for non-parallel needles.

The effect of electrode position is evaluated systematically by means of numerical models and experiments on phantoms for two different angles (5° and 30°) and compared with the case of parallel needles. Potato model was used as phantom, as this tissue becomes dark after few hours from electroporation. The electroporation degree was gauged from the color changings on the potatoes.

The distribution of electric field in different needle configuration is found by means of finite element analysis (FEA) and experiments on potatoes. The electric field level of inclined needles was compared with parallel needle case. In particular, the electric field distribution in the case of inclined needles could be very different with respect to the one in the case of parallel needles. The degree of enhancement for different inclinations is visualized by potato color intensity. The FEA suggested that the needle parallelism has to be maintained as possible as if the tips are closer to each other, the electric field intensity could be different with respect to the one in the case of parallel needles.

This paper analyzes the effect of inclined electrodes considering also the non-linearity of tissues.

Acting entrepreneurially in nascent industries is a complex endeavor characterized by uncertainty and ambiguity. Nevertheless, entirely new industries do emerge, often as a direct result of entrepreneurial behavior. We extend and apply discovery and creation approaches to study entrepreneurial behavior during industry emergence by means of qualitative analysis of a film about the personal computer (PC) industry℉s formative years. We find that discovery and creation behavior are fundamentally interrelated and share a common element: bricolage. Moreover, ideological activism is a major component of entrepreneurial behavior in a new industry℉s formative years during both creation and discovery processes. Implications for research and practice are discussed.

A recent paradigm-shift in patient care advocates for long-term recovery and quality of life in survivors of critical illness. Evidence suggests that occupational therapists in critical care can contribute to recovery in areas such as functional outcomes, length of stay and delirium, although poor role understanding can limit service-utilisation. The purpose of this study is to investigate current and future roles and practices of critical care occupational therapists in the UK.

Occupational therapists with clinical experience in adult critical care were invited to participate in a mixed-methods design using a locally developed online questionnaire and semi-structured interviews, concurrently. Descriptive statistics were generated through SPSS. Qualitative data were analysed using the framework approach.

Twelve occupational therapists participated in the survey element, with five continuing to interview. Occupational therapists described a multifaceted role in critical care where the majority reported practice in upper limb function, seating/positioning, cognition, psychosocial sequelae and discharge planning. Role and internal characteristics impacted on service delivery. It is envisaged that earlier intervention in a greater percentage of patients, a greater evidence-base, raising awareness and adequate staffing will be features for future development.

This study provides new insight into the current role and practices of adult critical care occupational therapists in England and generates insights into their role in addressing physical and non-physical morbidity for this patient cohort. Findings are preliminary in nature; however, future research is warranted to evaluate the effectiveness of interventions.