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This paper examines the effects on families of a broad range of intervention programs designed to assist family caregivers of persons with mental illness. In so doing, the paper critically discusses the intervention designs utilized, similarities and differences in intervention modalities, the characteristics of study subjects, and the effects of these intervention programs on a variety of caregiver outcomes. The paper addresses the degree to which particular interventions are more effective than others, and assesses the strengths, weaknesses, and limitations of these intervention studies. Implications for future practice, policy, and research are presented.