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Increased longevity is the success story of 20th‐century biomedicine, together with improvements in general living conditions, but it brings great challenges. Although many individuals do undergo what might be termed ‘successful ageing’, this is not a universal experience, for with older age comes a range of age‐related diseases and degenerations that can diminish, if not destroy, quality of life for some older individuals. Biogerontology is the study of the biology of ageing, a normal process but one that has the potential to contribute to age‐related disease. Its goal is to extend the proportion of a life that is healthy, an outcome that is desirable both at an individual and a societal level. One of the great insights from the last decade or more of biogerontology is the realisation that the ageing process is not a fixed, unchangeable process. Rather, it is controlled by genes and is open to experimental interventions that extend healthy lifespan, in species from microbes to mice. These findings have produced a sea change in the way the biogerontological community views ageing: not as a fixed, ‘inevitable’ process, but one where rates of ageing vary enormously according to genotype, and can be readily changed by interventions. This makes the biological process of ageing an attractive target both to understand, and target, age‐related conditions.

Up until the turn of the millennium, there had been very little positive representation of women and women in action characters in the action film genre. Two notable exceptions were Ellen Ripley in the Alien movies and Sarah Connor in the Terminator franchise. Whilst this has certainly changed over the last 20 years, one action/horror/science fiction heroine remains neglected: Project Alice in the six Resident Evil films. Portrayed by Milla Jovovich, and loosely based on the platform game character, Project Alice is strong, driven, motivated and tough. This chapter will, through detailed analysis of character, her physical presence through the clothing she wears, psychogeographical aspects, her use of weapons and narrative arc, clearly demonstrate the importance of Project Alice to the horror genre.

The purpose of this paper is to offer an overview of hate crime relating to people with autism spectrum disorders (ASD).

This is a discussion outlining some of the key evidence relating to ASD and hate crime.

For too long the issue of hate crime and autism has been neglected in spite of significant numbers of people with ASDs experiencing hate crime and/or harassment on a regular basis.

Although people with ASD are thought to be subject to high rates of hate crimes the literature is sparse when compared to other strands of hate crime such as race or religion.

The issue of cloned food labeling came to the forefront on January 15, 2008, with the release of a controversial report by the Food and Drug Administration (FDA). This paper aims to explore issues surrounding cloned food sources, specifically the increasingly vocal demands by the American public for mandatory labeling.

This paper reviews literature to examine the culture and structure of the FDA over the past ten years. Ethical, economic and public health concerns surrounding cloned food sources are also examined. Comparisons are made to the shared history of genetically modified organisms (GMOs). Political process and implementation of the Cloned Food Labeling Act (S. 414) are explored.

The FDA faces legal and cultural pressure to speed medications to market. The processes created by this struggle also affect the regulation of agriculture; this can be seen in the similar histories of GMOs and cloned food. Ethical issues surrounding cloned food labeling include animal welfare and the usurpation of the creator's role. Other ethical issues are entwined in health and economic concerns. Health issues include the capacity of the FDA to track allergic reactions and the possibility of future protein abnormalities among consumers. Environmental and herd health are identified as more global health concerns.

The combined economics of the biotech cloning and agricultural industries invert the usual law of supply and demand. This economic dynamic may either hurt small farmers or potentially benefit those who eschew cloning due to ethical or financial constraints. The current political climate exerts an interesting dynamic on the cloned food labeling debate. Consumer issues are pushed aside in the excitement of a new administration and more pressing issues such as the recessed economy. Biotech industries have the ability to maintain focus in the midst of distracting national issues; however, legislative opponents may have newfound strength with a majority congress.

Functioning as an historical overview and theoretical framework for those studying cloned food safety and labeling issues, this paper is useful in engendering ethical discussions. It also highlights the need for statistical and public health research on cloned food safety.

Pediatric disorders, such as cerebral palsy and stroke, can result in thumb-in-palm deformity greatly limiting hand function. This not only limits children's ability to perform activities of daily living but also limits important motor skill development. Specifically, the isolated orthosis for thumb actuation (IOTA) is 2 degrees of freedom (DOF) thumb exoskeleton that can actuate the carpometacarpal (CMC) and metacarpophalangeal (MCP) joints through ranges of motion required for activities of daily living. The paper aims to discuss these issues.

IOTA consists of a lightweight hand-mounted mechanism that can be secured and aligned to individual wearers. The mechanism is actuated via flexible cables that connect to a portable control box. Embedded encoders and bend sensors monitor the 2 DOF of the thumb and flexion/extension of the wrist. A linear force characterization was performed to test the mechanical efficiency of the cable-drive transmission and the output torque at the exoskeletal CMC and MCP joints was measured.

Using this platform, a number of control modes can be implemented that will enable the device to be controlled by a patient to assist with opposition grasp and fine motor control. Linear force and torque studies showed a maximum efficiency of 44 percent, resulting in a torque of 2.39±1.06 in.-lbf and 0.69±0.31 in.-lbf at the CMC and MCP joints, respectively.

The authors envision this at-home device augmenting the current in-clinic and at-home therapy, enabling telerehabilitation protocols.

This paper presents the design and characterization of a novel device specifically designed for pediatric grasp telerehabilitation to facilitate improved functionality and somatosensory learning.