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The purpose of this study is to provide a micromixer for achieving effective mixing of two liquids. The mixing of two liquids is difficult to achieve in microfluidic chips because they cannot form turbulence at small dimensions and velocities.

In this paper, four kinds of passive micromixers based on splitting–recombination and chaotic convection are compared. First, a better E-shape mixing unit based on the previous F-shape mixing unit has been designed. Then, the E-shape mixing units are further combined to form three micromixers (i.e. E-mixer, SESM and FESM).

Finally, the mixing experimental results show that the mixing indexes of E-mixer, SESM and FESM are more than those of F-mixer when the Reynolds number range is from 0.5 to 100. And at Re = 15, the lowest mixing index of E-mixer is 71%, which is the highest of the four micromixers.

At Re = 80, the highest mixing index of F-mixer and E-mixer is 92 and 94 per cent, respectively, and then it begins to decrease. But the mixing index of SESM and FESM remains close to 100 per cent.

The effective, efficient and optimal design of micromixer is the need in the field of biochemical and biomedical diagnostic systems.

In this paper, multi-objective optimization of split and recombine micromixer (SRM) with different geometrical configurations is carried out. The finite element method-based three-dimensional models are prepared and analyzed using COMSOL Multiphysics 5.0 Software. Taguchi’s design of experiment (DoE), main effect plot analysis, ANOVA and grey relational analysis (GRA) method are used to find out optimum condition. The five geometrical parameters with three levels, namely, angle between inlets, pillar size, pillar shape, aspect ratio and constriction height of SRM are considered as design variables. The mixing index (MXI) and pressure drop (∆P) are considered objective functions.

The MXI is significantly influenced by pillar shape and aspect ratio, whereas the pressure drop (∆P) by constriction height. Maximum MXI (0.97) with minimum pressure drop (64,587 Pa) is the optimal conditions and obtained at 180 deg angle between inlets, 50 µm of pillar size, 1.5 of aspect ratio, 100 µm of constriction height and ellipse shape pillar cross-section, respectively.

This optimized SRM can be combined with lab-on-a-chip for biochemical and biomedical analysis.

This work is useful to obtain optimal geometry of SRM for getting efficient performance of micromixer.

The purpose of this study is to introduce an alternative construction for microfluidic micromixers, where the effect of the extruded filaments in the fused deposition modeling (FDM) technique is used to enhance mixing performance identified as a challenge in microfluidic micromixers.

A simple Y-shaped micromixer was designed and printed using FDM technique. Experimental and numerical studies were conducted to investigate the effect of the extruded filaments on the flow behavior. The effects of the extruded width (LW), distance between adjacent filaments (b) and filament height (h₁) are investigated on the mixing performance and enhancing mixing in the fabricated devices. The performance of fabricated devices in mixing two solutions was tested at flow rates of 5, 10, 20, 40, 80 and 150 µL/min.

The experimental results showed that the presence of geometrical features on microchannels, because of the nature of the FDM process, can act as ridges and generate a lateral transform through the transverse movement of fluids along the groove. The results showed the effect of increasing ridge height on the transverse movement of the fluids and, therefore, chaotic mixing over the ridges. In contrast, in the shallow ridge, diffusion is the only mechanism for mixing, which confirms the numerical results.

The study presents an exciting aspect of FDM for fabrication of micromixers and enhance mixing process. In comparison to other methods, no complexity was added in fabrication process and the ridges are an inherent property of the FDM process.

Flexible pressure sensor arrays have promising applications in analog haptics, reconfiguration of sensory functions, artificial intelligence, wearable devices and human-computer interaction. The force disturbance generated by the connecting material between the sensor array units will reduce the detection accuracy of the unit. The purpose of this paper is to propose a flexible pressure sensor with interference immunity capability. A C-type bridge flexible piezoelectric structure is used to improve the pressure perturbation. The interference immunity capability of the sensor has been improved.

In this paper, a C-type pressure sensor array structure by rapid injection moulding is manufactured through the positive piezoelectric effect of a piezoelectric material. The feasibility of C-type interference immunity structure in a flexible sensor array is verified by further analysis and experiment. A flexible pressure sensor array with C-type interference immunity structure has been proposed.

In this paper, we present the results of the perturbation experiment results of the C-type pressure sensor array, showing that the perturbation error is less than 8%. The test of the flexible sensor array show that the sensor can identify the curved angle of up to 120 °, and the output sensitivity of the sensor in the horizontal state reaches 0.12 V/N, and the sensor can withstand the pressure of 80 N. The flexible sensor can work stably in the stretch rate range of 0–8.6% and the stretch length range of 0–6 mm.

In this paper, C-type pressure sensor array structure is fabricated by rapid injection moulding for the first time. The research in this paper can effectively reduce the disturbance of input pressure on the sensor’s internal array and improve the output accuracy. The sensor can intuitively reflect the number of fingers sliding on the sensor by the order in which the maximum voltage appears. Due to the strong interference immunity capability and flexibility of the flexible sensor array mechanism, it has a broad application prospect in the practical fields of haptic simulation, perceptual function reconstruction, artificial intelligence, wearable devices and human–computer interaction.

The purpose of this paper is to investigate the gas flow characteristics in near wall region and the velocity slip phenomenon on the wall in nano-channels based on the molecular dynamics simulation.

An external gravity force was employed to drive the flow. The density and velocity profiles across the channel, and the velocity slip on the wall were studied, considering different gas temperatures and gas-solid interaction strengths.

The simulation results demonstrate that a single layer of gas molecules is adsorbed on wall surface. The density of adsorption layer increases with the decrease of gas temperature and with increase of interaction strength. The near wall region extents several molecular diameters away from the wall. The density profile is flatter at higher temperature and the velocity profile has the traditional parabolic shape. The velocity slip on the wall increases with the increase of temperature and with decrease of interaction strength linearly. The average velocity decreases with the increase of gas-solid interaction strength.

This research presents gas flow characteristics in near wall region and the velocity slip phenomenon on the wall in nano-channels. Some interesting results in nano-scale channels are obtained.

This paper aims to compare the performance of flow pulsation versus flow stirring in the context of mixing of a passive scalar at moderate Reynolds numbers in confined flows. This comparison has been undertaken in two limits: diffusion can be neglected as compared to convection (very large Peclet) and diffusion and convection effects are comparable. The comparison was performed both in terms of global parameters: pumping power and mixing efficiency and local flow topology.

The study has been addressed by setting up a common conceptual three-dimensional problem that consisted of the mixing of two parallel streams in a square section channel past a square section prism. Stirring and pulsation frequencies and amplitudes were changed and combined at an inlet Reynolds number of 200. The numerical model was solved using a finite volume formulation by adapting a series of open-source OpenFOAM computational fluid dynamic (CFD) libraries. For cases with flow pulsation, the icoFoam solver for laminar incompressible transient flows was used. For cases with stirring, the icoDyMFoam solver, which uses the arbitrary Lagrangian–Eulerian method for the description of the moving dynamical mesh, was used to model the prism motion. At the local flow topology level, a new method was proposed to analyze mixing. Time evolution of folding and wrinkling of sheets made up of virtual particles that travel along streak lines was quantified by generating lower rank projections of the sheets onto the spaces spanned by the main eigenvectors of an appropriate space-temporal data decomposition.

In the limit when convection is dominant, the results showed the superior performance of stirring versus flow pulsation both in terms of mixing and required pumping power. In the cases with finite Peclet, the mixing parameters by stirring and flow pulsation were comparable, but pulsation required larger pumping power than stirring. For some precise synchronization of stirring and pulsation, the mixing parameter reached its maximum, although at the expense of higher pumping power. At the local flow topology level, the new method proposed to quantify mixing has been found to correlate well with the global mixing parameter.

A new systematic comparative study of two methods, stirring and pulsation, to achieve mixing of passive scalars in the mini scale for confined flows has been presented. The main value, apart from the conclusions, is that both methods have been tested against the same flow configuration, which allows for a self-consistent comparison. Of particular interest is the fact that it has been found that accurate synchronization of both methods yields mixing parameters higher than those associated to both methods taken separately. This suggests that it is possible to synchronize mixing methods of a different nature to achieve optimum designs. The new theoretical method that has been proposed to understand the mixing performance at the local level has shown promising results, and it is the intention of the authors to test its validity in a broader range of flow parameters. All these findings could be taken as potential guidelines for the design of mixing processes in the mini scale in the process industry.

This review paper aims to introduce the inkjet printing as a tool for fabrication of flexible/wearable sensors. It summarizes inkjet printing techniques including various modes of operation, commonly used substrates and inks, commercially available inkjet printers and variables affecting the printing process. More focus is on the drop-on-demand printing mode, a strongly considered printing technique for patterning conductive lines on flexible and stretchable substrates. As inkjet-printed patterns are influenced by various variables related to its conductivity, resistivity, durability and dimensions of printed patterns, the main printing parameters (e.g. printing multilayers, inks sintering, surface treatment, cartridge specifications and printing process parameters) are reported. The embedded approaches of adding electronic components (e.g. surface-mounted and optoelectronic devices) to the stretchable circuit are also included.

In this paper, inkjet printing techniques for fabrication of flexible/stretchable circuits will be reviewed. Specifically, the various modes of operation, commonly used substrates and inks and variables affecting the printing process will be presented. Next, examples of inkjet-printed electronic devices will be demonstrated. These devices will be compared to their rigid counterpart in terms of ease of implementation and electrical behavior for wearable sensor applications. Finally, a summary of key findings and future research opportunities will be presented.

In conclusion, it is evident that the technology of inkjet printing is becoming a competitor to traditional lithography fabrication techniques, as it has the advantage of being low cost and less complex. In particular, this technique has demonstrated great capabilities in the area of flexible/stretchable electronics and sensors. Various inkjet printing methods have been presented with emphasis on their principle of operation and their commercial availability. In addition, the components of a general inkjet printing process have been discussed in details. Several factors affect the resulting printed patterns in terms of conductivity, resistivity, durability and geometry.

The paper focuses on flexible/stretchable optoelectronic devices which could be implemented in stretchable circuits. Furthermore, the importance and challenges related to printing highly conductive and highly stretchable lines, as well as reliable electronic devices, and interfacing them with external circuitry for power transmission, data acquisition and signal conditioning have been highlighted and discussed. Although several fabrication techniques have been recently developed to allow patterning conductive lines on a rubber substrate, the fabrication of fully stretchable wearable sensors remains limited which needs future research in this area for the advancement of wearable sensors.

This paper aims to present a research on utilization of an irreversible bonding between non-transparent low temperature co-fired ceramics (LTCC) and transparent poly(dimethylsiloxane) (PDMS). The research presented in this paper is focused on the technology and performance of the miniature microfluidic module for fluorescence measurement.

The chemical combination of both materials is achieved through surface modification using argon-oxygen dielectric barrier discharge (DBD) plasma. According to the performed spectroscopic analyses (X-ray photoelectron spectroscopy, XPS; attenuated total reflection-Fourier infrared spectroscopy, ATR-FTIR) and contact angle measurements, the LTCC and PDMS surfaces are oxidized during the process. The presented microfluidic module was fabricated using LTCC technology. The possibility for the fabrication of LTCC-PDMS microfluidic fluorescent sensor is studied. The performance of the sensor was examined experimentally.

As a result of DBD plasma oxidation, the LTCC and PDMS surfaces change in character from hydrophobic to hydrophilic and were permanently bonded. The presented LTCC-PDMS bonding technique was used to fabricate a microfluidic fluorescent sensor. The preliminary measurements of the sensor have proven that it is possible to observe the fluorescence of a liquid sample from a very small volume.

The presented research is a preliminary work which is focused on the fabrication of the LTCC-PDMS fluorescent sensor. The microfluidic device was positively tested only for ethanolic fluorescein solutions. Therefore, fluorescence measurements should be performed for biological specimen (e.g. DNA).

The LTCC-PDMS bonding technology combines the advantages of both materials. One the one hand, transparent PDMS with precise, transparent three-dimensional structures can be fabricated using hot embossing, soft lithography or laser ablation. On the other hand, rigid LTCC substrate consisting of microfluidic structures, electric interconnections, heaters and optoelectronic components can be fabricated. The development of the LTCC-PDMS microfluidic modules provides opportunity for the construction of a lab-on-chip, or micro-total analysis systems-type system, for analytical chemistry and fast medical diagnoses.

This paper shows utilization of the PDMS-LTCC bonding technology for microfluidics. Moreover, the design, fabrication and performance of the PDMS-LTCC fluorescent sensor are presented.

The characteristics of fluid motions in micro-channel are strong fluid-wall surface interactions, high surface to volume ratio, extremely low Reynolds number laminar flow, surface roughness and wall surface or zeta potential. Due to zeta potential, an electrical double layer (EDL) is formed in the vicinity of the wall surface, namely, the stern layer (layer of immobile ions) and diffuse layer (layer of mobile ions). Hence, its competent designs demand more efficient micro-scale mixing mechanisms. This paper aims to therefore carry out numerical investigations of electro osmotic flow and mixing in a constricted microchannel by modifying the existing immersed boundary method.

The numerical solution of electro-osmotic flow is obtained by linking Navier–Stokes equation with Poisson and Nernst–Planck equation for electric field and transportation of ion, respectively. Fluids with different concentrations enter the microchannel and its mixing along its way is simulated by solving the governing equation specified for the concentration field. Both the electro-osmotic effects and channel constriction constitute a hybrid mixing technique, a combination of passive and active methods. In microchannels, the chief factors affecting the mixing efficiency were studied efficiently from results obtained numerically.

The results indicate that the mixing efficiency is influenced with a change in zeta potential (ζ), number of triangular obstacles, EDL thickness (λ). Mixing efficiency decreases with an increment in external electric field strength (Ex), Peclet number (Pe) and Reynolds number (Re). Mixing efficiency is increased from 28.2 to 50.2% with an increase in the number of triangular obstacles from 1 to 5. As the value of Re and Pe is decreased, the overall percentage increase in the mixing efficiency is 56.4% for the case of a mixing micro-channel constricted with five triangular obstacles. It is also vivid that as the EDL overlaps in the micro-channel, the mixing efficiency is 52.7% for the given zeta potential, Re and Pe values. The findings of this study may be useful in biomedical, biotechnological, drug delivery applications, cooling of microchips and deoxyribonucleic acid hybridization.

The process of mixing in microchannels is widely studied due to its application in various microfluidic devices like micro electromechanical systems and lab-on-a-chip devices. Hence, its competent designs demand more efficient micro-scale mixing mechanisms. The present study carries out numerical investigations by modifying the existing immersed boundary method, on pressure-driven electro osmotic flow and mixing in a constricted microchannel using the varied number of triangular obstacles by using a modified immersed boundary method. In microchannels, the theory of EDL combined with pressure-driven flow elucidates the electro-osmotic flow.

The on-chip high-throughput mixing process is one of the main challenges in the preparation process in clinical diagnostics. Because of high laminar flow in micro-channel, the fluid should be disturbed by external force. This paper aims to study pulsed AC electrothermal flow and the multiphysic interaction between the fluid behavior, external electric field, temperature field and convection-diffusion field to generate perturbation effect inside the channel.

A set of numerical simulations were carried out by multiphysic interactions between the fluid behavior, external electric field, temperature field and convection-diffusion field to generate the pulsed AC electrothermal flow inside the channel. Behavior of electrode–electrolyte system is discussed using the electrical lumped circuit model.

Highly efficient temperature gradients are generated by applying pulsed electric potential over the electrodes; as a result, efficient secondary flows form inside the channel. The proposed method increases the interfacial contact area between the fluids and enhances the molecular diffusion transport phenomena. Maximum temperature rise of 4.1 K is observed in the gap between the electrodes for 0.08 S/m fluid medium, where the electric field is much stronger than elsewhere. Velocity field and concentration analysis reveal high performance perturbation effects for the mixing process. The periodic stretching and folding effects increase the interfacial contact area between the fluids by using pulsed AC electrothermal flow. Based on the results, 83 per cent mixing efficiency is achieved for 0.08 S/m fluid medium with a microchannel length of 400 µm. Both the mixing efficiency and generated temperature rise increase by increasing the fluid ionic strength.

The ability to generate low temperature rise is very important for AC electrothermally driven fluidic chips such as immunoassay chips. In the present research, a novel actuation mechanism has been proposed to generate AC electrothermal manipulation mechanism and enhance the mixing efficiency by using pulsed AC electrothermal flow.