Search results

This research intended the utilization of Javanese turmeric (0.4% w/v) as a kombucha substrate and analysis of its hepatoprotective activity, in comparison against nonfermented Javanese turmeric beverage (JTB) and black tea kombucha.

Forty-two healthy male Balb/c mice (two- to three-week-old, 20–30 g) were divided into six groups with seven replicates each. The treatments were normal diet, normal diet + Javanese turmeric kombucha (JTK), normal diet + diethylnitrosamine (DEN), DEN + JTB, DEN + JTK, DEN + black tea kombucha. Kombuchas and JTB were given at 0.3 mL/20 g BW/d. DEN was induced intraperitoneally at a dose of 100 mg/kg. Observed biomarkers were blood serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activity, serum malonaldehyde (MDA), as well as liver histology. Data were analyzed using analysis of variance.

Among DEN-induced groups, JTK significantly (p < 0.05) diminished the level of blood SGPT, SGOT and serum MDA. JTK also had lower blood SGPT (8.604 ± 2.195 U/L) and serum MDA levels (2.884 ± 0.083 nM/mL) compared to the normal group (8.604 ± 2.195 U/L and 5.050 ± 0.998 nM/mL, respectively). JTK also produced the least damaged liver-cell numbers.

JTK demonstrated better hepatoprotective activity compared to JTB.

Renal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.

Experimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.

The following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.

SAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.

Aqueous zinc-ion battery has broad application prospects in smart grid energy storage, power tools and other fields. Co₃O₄ is one of the ideal cathode materials for water zinc-ion batteries due to their high theoretical capacity, simple synthesis, low cost and environmental friendliness. Many studies were concentrated on the synthesis, design and doping of cathodes, but the effect of process parameters on morphology and performance was rarely reported.

Herein, Co₃O₄ cathode material based on carbon cloth (Co₃O₄/CC) was prepared by different temperatures hydrothermal synthesis method. The temperatures of hydrothermal reaction are 100°C, 120°C, 130°C and 140°C, respectively. The influence of temperatures on the microstructures of the cathodes and electrochemical performance of zinc ion batteries were investigated by X-ray diffraction analysis, scanning electron microscopy, cyclic voltammetry curve, electrochemical charging and discharging behavior and electrochemical impedance spectroscopy test.

The results show that the Co₃O₄/CC material synthesized at 120°C has good performance. Co₃O₄/CC nanowire has a uniform distribution, regular surface and small size on carbon cloth. The zinc-ion battery has excellent rate performance and low reaction resistance. In the voltage range of 0.01–2.2 V, when the current density is 1 A/g, the specific capacity of the battery is 108.2 mAh/g for the first discharge and the specific capacity of the battery is 142.6 mAh/g after 60 charge and discharge cycles.

The study aims to investigate the effect of process parameters on the performance of zinc-ion batteries systematically and optimized applicable reaction temperature.