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1 – 10 of 320
Article
Publication date: 1 June 1997

E.T. Powner and F. Yalcinkaya

Discusses intelligent materials, intelligent material‐based sensors, their transducing methods, and different kinds of transducers used with smart material‐based sensors…

2052

Abstract

Discusses intelligent materials, intelligent material‐based sensors, their transducing methods, and different kinds of transducers used with smart material‐based sensors. Assumes that the future of intelligent sensors will almost totally depend on intelligent chemistry and intelligent instrumentation. Molecular recognition will widen the horizons of smart systems with the help of VLSI‐based design and fabrication. Discusses different sensor mechanisms, such as ENFETs, immunoFETs, ISFETs and chemFETs and takes a detailed look at potentiometric, amperometric and optical biosensors.

Details

Sensor Review, vol. 17 no. 2
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 1 March 1987

P. Roef

Optical fibre sensors are finding wide applications in biotechnology and medicine, as a European specialist explains.

Abstract

Optical fibre sensors are finding wide applications in biotechnology and medicine, as a European specialist explains.

Details

Sensor Review, vol. 7 no. 3
Type: Research Article
ISSN: 0260-2288

Article
Publication date: 19 January 2015

Xingya Wang and Guangchang Pang

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide…

Abstract

Purpose

This paper aims to provide a detailed review of weak interaction biosensors and several common biosensor methods for magnifying signals, as well as judiciously guide readers through selecting an appropriate detecting system and signal amplification method according to their research and application purpose.

Design/methodology/approach

This paper classifies the weak interactions between biomolecules, summarizes the common signal amplification methods used in biosensor design and compares the performance of different kinds of biosensors. It highlights a potential electrochemical signal amplification method: the G protein signaling cascade amplification system.

Findings

Developed biosensors which, based on various principles, have their own strengths and weaknesses have met the basic detection requirements for weak interaction between biomolecules: the selectivity, sensitivity and detection limit of biosensors have been consistently improving with the use of new signal amplification methods. However, most of the weak interaction biosensors stop at the research stage; there are only a minority realization of final commercial application.

Originality/value

This paper evaluates the status of research and application of weak interaction biosensors systematically. The G protein signaling cascade amplification system proposal offers a new avenue for the research and development of electrochemical biosensors.

Article
Publication date: 1 December 2017

Nur Alia Sheh Omar and Yap Wing Fen

This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become…

Abstract

Purpose

This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become an alternative DENV sensor.

Design/methodology/approach

In this review, the existing standard laboratory techniques to diagnosis of DENV are discussed, together with their drawbacks. To overcome these drawbacks, SPR has been aimed to be a valuable optical biosensor for identification of antibodies to the DENV antigen. The review also includes the future studies on three-dimensional poly(amidoamine) (PAMAM) dendrimer-surface-assembled monolayer (SAM)-Au multilayer thin films, which are envisaged to have high potential sensitive and selective detection ability toward target E-proteins.

Findings

Application of SPR in diagnosis of DENV emerged over recent years. A wide range of immobilized biorecognition molecules have been developed to combine with SPR as an effective sensor. The detection limit, sensitivity and selectivity of SPR sensing in DENV have been enhanced from time to time, until the present.

Originality/value

The main purpose of this review is to provide authors with up-to-date and useful information on sensing DENV using SPR and to introduce a novel three-dimensional PAMAM-SAM-Au multilayer thin films for future research on SPR sensing applications.

Details

Sensor Review, vol. 38 no. 1
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 12 August 2019

Nurul Hazwani Daud, Siti Nurbaya Oslan, Thean Chor Leow and Abu Bakar Salleh

The main purpose of this study is to demonstrate the development of an enzyme-based sensor for haloalkane detection. Haloalkane is a toxic compound that is found as…

Abstract

Purpose

The main purpose of this study is to demonstrate the development of an enzyme-based sensor for haloalkane detection. Haloalkane is a toxic compound that is found as genotoxic impurities in pharmaceutical products and contaminants in waste. The need to investigate the genotoxic level in pharmaceutical manufacturing is very crucial because of its toxicity effects on human health. The potential of mini protein as an alternative bioreceptor was explored with the aim to be more effective and stable under extreme conditions.

Design/methodology/approach

Mini proteins of haloalkane dehalogenase (HLD) were computationally designed and experimentally validated. Tapered multimode fiber (TMMF) was bio-functionalized with a bioreceptor either native (positive control) or mini protein. The absorbance-based sensor resulting from the binding interaction of mini protein with haloalkane was monitored through a wavelength range of 200-1,300 nm.

Findings

An increment of the UV absorption is observed at 325 nm when haloalkane interacted with the immobilized bioreceptors, native or mini protein. Both biosensors displayed a continuous response over the range of 5-250 µM haloalkane. They also had the capability to detect haloalkanes below 1 min and with an operational stability of up to seven days without significant loss of sensitivity.

Practical implications

The results indicate the potential viability of the enzyme HLD-based sensor to monitor the existence of haloalkane in both pharmaceutical and environmental products.

Originality/value

The paper describes an outcome of experimental work on TMMF-based biosensor coated with HLD for label-free haloalkane detection. Mini protein can be used as an effective bioreceptor with some structural modification to improve functionality and stability.

Details

Sensor Review, vol. 39 no. 6
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 19 September 2016

Qianqian Zheng, Liangliang Chen, Luyao Lu and Xuesong Ye

Olfaction plays a very important role in daily life. The olfactory system has the ability to recognize, discriminate and identify thousands of odorant compounds with…

Abstract

Purpose

Olfaction plays a very important role in daily life. The olfactory system has the ability to recognize, discriminate and identify thousands of odorant compounds with extremely high sensitivity and specificity. The research on olfactory system has very important values in exploring the mechanisms of information processing in the other sensory nervous systems and brain. Recently, with the development of molecular biological and microelectronics technology research, the study of olfactory cell-based sensors has made great progress. The purpose of this paper is to provide details of recent developments in olfactory cell-based sensors.

Design/methodology/approach

Following an introduction, this paper first discusses some olfactory cell-based biosensors, which focus on the light-addressable potentiometric sensors and the microelectrode arrays. Second, surface modification, microfabrication and microfluidic technology which can improve the efficiency of cell immobilization will be summarized. The research trends of olfactory cell-based sensor in future will be proposed.

Findings

This paper shows that the biosensors’ performance is expected to be greatly improved due to the fast development of nanotechnology, optical technology and microelectronics. More and more emerging intelligent olfactory sensors will have a promising prospect in many application fields, including food quality and safety assessment, environmental monitor and human diseases detection.

Originality/value

This paper provides a detailed and timely review of the rapidly growing research in the olfactory cell-based sensors.

Details

Sensor Review, vol. 36 no. 4
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 19 June 2019

İlker Polatoğlu and Fehime Cakıcıoglu Ozkan

This paper aims to present a novel and cost-effective optical biosensor design by simple preparation method for detection of “parathion-methyl,” which is a model pesticide…

Abstract

Purpose

This paper aims to present a novel and cost-effective optical biosensor design by simple preparation method for detection of “parathion-methyl,” which is a model pesticide pose to public health and the environment.

Design/methodology/approach

The optical enzyme biosensor (TCA) for detection of pesticide “parathion-methyl” was developed on the basis of immobilization of tyrosinase enzyme on chitosan film by adsorption technique. The analytic performance of TCA was investigated by measuring its activity with Ultraviolet (UV) visible spectrophotometer.

Findings

Uniform porous network structure and protonated groups of chitosan film provided a microenvironment for tyrosinase immobilization evident from Fourier transform infrared (FTIR) spectroscopy and Atomic Force Microscopy analysis. TCA has a wide linear detection range (0-1.03 µM) with high correlation coefficient and it can detect the parathion-methyl concentration as low as 159 nM by noncompetitive inhibition kinetics. Using the TCA sensor both for ten times and at least 45 days without a significant loss in its activity are the indicators of its good operational and storage stability. Moreover, TCA can be applicable to tap water, providing a promising tool for pesticides detection.

Originality/value

This is the first time to use the in situ analytical technique that can improve the performance of optical enzyme sensor provided to control the pesticide residue better with respect to traditional techniques. The effect of organic solvents on the performance of optical enzyme biosensor was investigated. Inhibition kinetic of the solvents rarely encountered in literature was also studied besides the pH and temperature tolerance of the optical biosensor.

Details

Sensor Review, vol. 39 no. 4
Type: Research Article
ISSN: 0260-2288

Keywords

Content available
Article
Publication date: 23 June 2020

Pankaj Mandpe, Bala Prabhakar, Hunny Gupta and Pravin Shende

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In…

1805

Abstract

Purpose

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In diabetic patients, the self-monitoring of blood glucose (BG) levels through minimally invasive techniques provides a quick method of measuring their BG concentration, unlike conventional laboratory measurements. The drawbacks of minimally invasive techniques include physical pain, anxiety and reduced patient compliance. To overcome these limitations, researchers shifted their attention towards the development of a pain-free and non-invasive glucose monitoring system, which showed encouraging results.

Design/methodology/approach

This study reviews the development of minimally and non-invasive method for continuous glucose level monitoring in diabetic or hyperglycemic patients. Specifically, glucose monitoring using non-invasive techniques, such as spectroscopy-based methods, polarimetry, fluorescence, electromagnetic variations, transdermal extraction-based methods and using body fluids, has been discussed. The various strategies adopted for improving the overall specificity and performance of biosensors are discussed.

Findings

In conclusion, the technology of glucose oxidase-based biosensors for glucose level monitoring is becoming a strong competitor, probably because of high specificity and selectivity, low cost and increased patient compliance. Many industries currently working in this field include Google, Novartis and Microsoft, which demonstrates the significance and strong market potential of self-monitored glucose-oxidase-based biosensors in the near future.

Originality/value

This review paper summarizes comprehensive strategies for continuous glucose monitoring (CGM) in diabetic patients using non-invasive glucose-oxidase biosensors. Non-invasive techniques received significant research interest because of high sensitivity and better patient compliance, unlike invasive ones. Although the results from these innovative devices require frequent calibration against direct BG data, they might be a preferable candidate for future CGM. However, the challenges associated with designing accurate level sensors to biomonitor BG data easily and painlessly needs to be addressed.

Details

Sensor Review, vol. 40 no. 4
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 25 January 2008

Vinod Kumar Khanna

This paper aims to discover the novelties in biosensor fabrication brought about by breakthroughs in nanomaterials and process techniques, the resulting enhancement in…

6279

Abstract

Purpose

This paper aims to discover the novelties in biosensor fabrication brought about by breakthroughs in nanomaterials and process techniques, the resulting enhancement in biosensor functionalities, new applications and future possibilities.

Design/methodology/approach

The impact of nanotechnology on biosensor advancement has been examined. Different directions of biosensor research in the nano era have been highlighted. These include the efforts made through nanotechnology to improve the performance parameters of the existing biosensors, and for implementation of innovative biosensor concepts.

Findings

Nanotechnology is a key technology in biosensor development. It has permeated into the biosensor field and brought in its wake far‐reaching changes.

Practical implications

Biosensor science and engineering are central to virtually all aspects of life including medical diagnostics, environmental monitoring and biotechnological process control. Therefore, the progress in biosensors brought about by nanotechnology influences one's everyday life.

Originality/value

The study helps in understanding the applications of nanotechnology in fabricating a new generation of biosensors with improved characteristics. It provides information of value to those involved in biosensor research.

Details

Sensor Review, vol. 28 no. 1
Type: Research Article
ISSN: 0260-2288

Keywords

Article
Publication date: 4 April 2018

Bushra Rafique, Mudassir Iqbal, Tahir Mehmood and Muhammad Ashraf Shaheen

This review aims to focus on recent reported research work on the construction and function of different electrochemical DNA biosensors. It also describes different…

1504

Abstract

Purpose

This review aims to focus on recent reported research work on the construction and function of different electrochemical DNA biosensors. It also describes different sensing materials, chemistries of immobilization probes, conditions of hybridization and principles of transducing and amplification strategies.

Design/methodology/approach

The human disease-related mutated genes or DNA sequence detection at low cost can be verified by the electrochemical-based biosensor. A range of different chemistries is used by the DNA-based electrochemical biosensors, out of which the interactions of nanoscale material with recognition layer and a solid electrode surface are most interesting. A diversity of advancements has been made in the field of electrochemical detection.

Findings

Some important aspects are also highlighted in this review, which can contribute in the creation of successful biosensing devices in the future.

Originality/value

This paper provides an updated review of construction and sensing technologies in the field of biosensing.

Details

Sensor Review, vol. 39 no. 1
Type: Research Article
ISSN: 0260-2288

Keywords

1 – 10 of 320