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This paper is based on seminar, workshop and lecture materials presented at national and international conferences, and follows an invitation to cover this topic as part of a one‐day conference on mental health issues in autism spectrum disorders (Staufenberg, 2005; 2007). The paper will seek to a) outline a review of the current evidence base and clinical approaches to the appraisal of risk behaviour or aggressive conduct in general and forensic psychiatric practice, before b) reviewing the current issues in the clinical risk appraisal in individuals with complex neurodevelopmental syndromes of the high functioning autism spectrum, and in particular Asperger's syndrome.References based on clinical and structured instrument‐based risk appraisal will also introduce the pertinence of assessing personality traits in individuals with Asperger's syndrome, with specific reference to forensic neuropsychiatry‐based expertise and case vignettes. A discussion of potential research directions and collaborations will conclude this introductory guide to the emerging field of forensic developmental neuropsychiatry.