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In the developing field of nano-materials synthesis, copper oxide nanoparticles (NPs) are deemed to be one of the most significant transition metal oxides because of their intriguing characteristics. Its synthesis employing green chemistry principles has become a key source for next-generation antibiotics attributed to its features such as environmental friendliness, ease of use and affordability. Because they are more environmentally benign, plants have been employed to create metallic NPs. These plant extracts serve as capping, stabilising or hydrolytic agents and enable a regulated synthesis as well.

Organic chemical solvents are harmful and entail intense conditions during nanoparticle synthesis. The copper oxide NPs (CuO-NPs) synthesised by employing the green chemistry principle showed potential antitumor properties. Green synthesised CuO-NPs are regarded to be a strong contender for applications in the pharmacological, biomedical and environmental fields.

The aim of this study is to evaluate the anticancer potential of CuO-NPs plant extracts to isolate and characterise the active anticancer principles as well as to yield more effective, affordable, and safer cancer therapies.

This review article highlights the copper oxide nanoparticle's biomedical applications such as anticancer, antimicrobial, dental and drug delivery properties, future research perspectives and direction are also discussed.

Efficient thermal management of central processing unit (CPU) cooling systems is vital in the context of advancing information technology and the demand for enhanced data processing speeds. This study aims to explore the thermal performance of a CPU cooling setup using a cylindrical porous metal foam heat sink.

Nanofluid flow through the metal foam is simulated using the Darcy–Brinkman–Forschheimer equation, accounting for magnetic field effects. The temperature distribution is modeled through the local thermal equilibrium equation, considering viscous dissipation. The problem’s governing partial differential equations are solved using the similarity method. The CPU’s hot surface serves as a solid wall, with nanofluid entering the heat sink as an impinging jet. Verification of the numerical results involves comparison with existing research, demonstrating strong agreement across numerical, analytical and experimental findings. Ansys Fluent® software is used to assess temperature, velocity and streamlines, yielding satisfactory results from an engineering standpoint.

Investigating critical parameters such as Darcy number (10⁻⁴ ≤ Da_D ≤ 10⁻²), aspect ratio (0.5 ≤ H/D ≤ 1.5), Reynolds number (5 ≤ Re_D,bf ≤ 3500), Eckert number (0 ≤ EC_bf ≤ 0.1) , porosity (0.85 ≤ ε ≤ 0.95), Hartmann number (0 ≤ Ha_D,bf ≤ 300) and the volume fraction of nanofluid (0 ≤ φ ≤ 0.1) reveals their impact on fluid flow and heat sink performance. Notably, Nusselt number will reduce 45%, rise 19.2%, decrease 14.1%, and decrease 0.15% for Reynolds numbers of 600, with rising porosity from 0.85 to 0.95, Darcy numbers from 10⁻⁴ to 10⁻², Eckert numbers from 0 to 0.1, and Hartman numbers from 0 to 300.

Despite notable progress in studying thermal management in CPU cooling systems using porous media and nanofluids, there are still significant gaps in the existing literature. First, few studies have considered the Darcy–Brinkman–Forchheimer equation, which accounts for non-Darcy effects and the flow and geometric interactions between coolant and porous medium. The influence of viscous dissipation on heat transfer in this specific geometry has also been largely overlooked. Additionally, while nanofluids and impinging jets have demonstrated potential in enhancing thermal performance, their utilization within porous media remains underexplored. Furthermore, the unique thermal and structural characteristics of porous media, along with the incorporation of a magnetic field, have not been fully investigated in this particular configuration. Consequently, this study aims to address these literature gaps and introduce novel advancements in analytical modeling, non-Darcy flow, viscous dissipation, nanofluid utilization, impinging jets, porous media characteristics and the impact of a magnetic field. These contributions hold promising prospects for improving CPU cooling system thermal management and have broader implications across various applications in the field.