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The trade agreements among major trading countries can open new prospects of development and growth for global economy. The policy changes by a major trading country can alter the global trade and connection patterns. The trade agreement known as Trans-Pacific Partnership (TPP) was between 12 “Pacific-rim” countries signed earlier in 2016 indicates an upcoming and major policy change for global economy (presidential memorandum to withdraw the United States from TPP was signed in January 2017). The agreement would influence the issues related to “economic growth, employment, innovation, productivity, and competitiveness” of every partner and linked economy. This study illustrates how Asia Pacific’s major countries are interlinked with each other, the important sectors and the strength of connections. The level of interconnectedness might have been transformed within regional trade network because of varying global economic patterns and demand trends. The study focuses on the aspects related to agreement and reduction in tariffs that may change the global trading scenarios and appropriate position for region’s prominent and developing economies after implementation of the agreement.