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As a little research has been conducted to understand the factors influencing users’ intentions to adopt blockchain-based telemedicine (BBT), it is important to investigate BBT acceptance as incorporation of blockchain technology can solve telemedicine-related issues. Accordingly, this study aims to investigate the factors influencing behavioral intentions (BI) to adopt BBT.

An integrated model comprising the constructs taken from technology–organization–environment framework, technology acceptance model, unified theory of acceptance and use of technology and theory of planned behavior based on their relevance to the context and the objectives of the study has been used for this research. A quantitative approach has been used to test the hypotheses, for which the data was collected from 324 respondents through a self-administered questionnaire. Partial least squares structural equation modeling has been used to test the hypotheses.

The results of the study show that relative advantage, perceived usefulness, trust and perceived ease of use have a significant impact on BI to adopt BBT, whereas regulatory support, subjective norms and facilitating conditions do not have any significant impact on the same.

As the concept of BCT in Pakistan is at its nascent stage and literature regarding this technology’s adoption is also limited, researchers and scholars can apply it to several other fields in Pakistan. For example, this study can be extended to explore the factors influencing blockchain adoption in areas such as education, logistics, transportation, finances and management. This research only considers the direct effects of constructs on BI to adopt BBT and does not consider any mediation and moderations constructs. Future researchers can also study the influence of mediation and moderation constructs on BI to adopt BCT.

Although studies on the acceptance of telemedicine exist, there is a gap concerning the acceptance of BBT, which the current study helps to bridge. From a practical standpoint, the current study makes a highly valuable contribution toward understanding acceptance factors for BBT projects, leading to help policymakers devise policies to promote telemedicine.