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Entrepreneurship researchers use various types of screening criteria to select samples for study. In that selecting these criteria is, in effect, choosing a definition or model of entrepreneurship, the consequences are immense and have had a direct impact on the generalizability of research and theory development in our field. The purpose of this study is to help entrepreneurship researchers better understand these consequences and, thereby, improve our understanding of entrepreneurial phenomenon. Four of the most commonly used screening criteria are included in this study: firm age, firm size, firm growth, and innovation. Based on a sample of 368 manufacturing firms, the results indicate that few firms fit all or even most of the considered screening criteria and independent-dependent variable relationships vary considerably by screening criteria selection.