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The contribution of non‐digestible carbohydrates to colon cancer protection is becoming more clearly established. While the causes of colon cancer are multifold, experimental and epidemiological evidence suggests that various dietary components play a significant role in the mitigation of various colon cancer‐inducing factors. Recent developments in the characterization and quantification of these components, which include fructooligosaccharides, dietary fiber and resistant starch, indicate an association between their intake and colon cancer prevention. Considerable physicochemical modifications occur in the colon with the presence of non‐digestible carbohydrates, primarily because these carbohydrates act as selective prebiotic fermentation substrates for beneficial colonic probiotic bacteria to produce short chain fatty acids (SCFA). These SCFA elicit effects such as alteration in preneoplastic lesions, enzyme induction, suppression of mutations, and binding of potential carcinogens. Prebiotic‐probiotic interaction and activity is therefore key in colon cancer protection by non‐digestible carbohydrates.

As the substantial contribution of resistant starch to food nutritional quality and disease prevention becomes more obvious, the challenge of incorporating it in the diet and increasing its intake remains. Western diets in particular, are estimated to have very low levels of resistant starch, and this has been linked to the prevalence of some of the non‐infectious diseases such as colorectal cancer and type 2 diabetes. There is a need therefore to increase the consumption of foods high in resistant starch. Resistant starch levels in food are determined by the nature of the starch and the processing techniques applied in production. Application of processes that optimize and stabilize resistant starch and its utilization as an ingredient in functional food product development will greatly contribute to its availability for consumption. This will enable attainment of the attendant physiological benefits of resistant starch, primarily in the area of disease prevention.