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This scientific article aims to evaluate the efficacy of the drug Doxorubicin for treating hepatocellular carcinoma (HCC) in Egypt. The study analyzes data from patients referred to a multi-disciplinary consultation at the National Cancer Institute, Cairo University. The study includes 40 intermediate-stage HCC patients who underwent treatment with either Doxorubicin-Lipiodol or Doxorubicin-loaded drug-eluting beads-trans-arterial chemoembolization (DEB-TACE).

Patients referred to a multi-disciplinary consultation at the National Cancer Institute, Cairo University with a possible diagnosis of HCC in the intermediate stage were eligible for the study.

The study finds that the plasma peak concentration of Doxorubicin is significantly higher in patients treated with Lipiodol compared to those treated with DEB-TACE. The median plasma peak concentration of patients treated with Lipiodol was significantly higher 424 (202.5–731) than the peak level of patients treated with beads 84.95 (26.6–156.5) with p-value = 0.036. However, there is no significant difference in other pharmacokinetic parameters between the two treatment groups. The research article also investigates the genetic polymorphisms in HCC patients treated with Doxorubicin-Lipiodol and Doxorubicin-loaded DEB-TACE. It identifies a significant association between the ABCB1 gene (C3435T) and the concentration of Doxorubicin in plasma. Patients with the CCand computed tomography (CT) genotypes of ABCB1 have higher concentrations of Doxorubicin compared to those with the TT genotype. Furthermore, the study examines the progression-free survival rates and tumour response in the two treatment groups. It demonstrates that DEB-TACE patients have a higher progression-free survival rate compared to cTACE patients. DEB-TACE also leads to better tumour regression.

The current study helps to increase the understanding of the genetic factors that may contribute to HCC susceptibility in the Egyptian population. However, it is essential to consider that genetic polymorphism is just one aspect of HCC risk, and other factors such as environment, lifestyle and viral infections also play crucial roles. Further research is needed to elucidate the complex interactions between genetic and environmental factors in HCC development among Egyptians.

The purpose of the paper is to present a service design (SD)-based methodology developed to help small and medium enterprises (SMEs) undertake organisational change.

This research used the design science research methodology, which enabled the creation of the Service Design for Organisational Change (SD4OCh) methodology. A real case study of a small service company specialised in neuropsychological disorders was used for the definition and validation of SD4OCh.

The main outcome of this study is the SD4OCh methodology, which is based on three key stages: diagnosis (knowing where to begin by detecting the organisation's strengths and weaknesses), innovation (improving the structure/processes and designing/redesigning services by employing a customer-centric approach), and implementation (enabling the definition of the route towards organisational change). There is also a transversal evaluation stage, which quantifies the organisational changes.

This study adds valuable knowledge to the service science research field and contributes to the awareness of the usefulness of SD theory within companies, especially those which are small and medium-sized, since those companies lack the tools and methods required to tackle organisational change, signifying that the challenges the companies confront are different to those of larger companies.

Although this is a SD-based research, the SD4OCh methodology was developed in order to enable companies to make holistic changes, namely, to innovate their services, structure, and processes, thus supporting and guiding organisational change.

The purpose of this study is to explore the paranormal tourist experience on ghost tours, taking into account the participants’ perceptions and their prior knowledge of the paranormal, in order to determine the principal components of the future of paranormal tourist experience.

The study is divided into two phases. The first phase is based on participant observation during a ghost tour. The second phase is based on a previously published framework for paranormal tourism. It introduces a qualitative adaptation of the orchestra model to look in-depth at how experiences with paranormal tours might shape the future of tourism as a major subtype.

Paranormal tourism has external (situational-enchantment, historical, mystical, ghostly and unsolved mysteries) and internal (affective, cognitive, sensory, behavior and relationship) components that are inter-linked. Future paranormal tourist experiences (FPTEs) must be focused on enhancing these aspects in order to offer an immersive experience.

Consequently, this paper proposes the FPTE model.

This paper aims to provide an overview of the application of blockchain to agri-food supply chains, including key issues and trends. It examines the state of the art and conceptual structure of the field and proposes an agenda to guide future research.

This article performs a bibliometric analysis using VOSviewer software on a sample of 205 articles from the WoS database to identify research trend topics.

The number of publications in this area has increased since 2020, which shows a growing research interest. The research hotspots are related to the integration of blockchain technology in the agri-food supply chain for traceability, coordination between all actors involved, transparency of operations and improvement of food safety. Furthermore, this is linked to sustainability and the achievement of the sustainable development gtoals (SDGs), while addressing key challenges in the implementation of blockchain-based technologies in the agri-food supply chain.

The application of blockchain in the agri-food supply chain may consider four key aspects. Firstly, the implementation of blockchain can improve the traceability of food products. Secondly, this technology supports sustainability issues and could avoid disruptions in the agri-food supply chain. Third, blockchain improves food quality and safety control throughout the supply chain. Fourthly, the findings show that regulation is needed to improve trust between stakeholders.

The paper provides a comprehensive overview of the blockchain phenomenon in the agri-food supply chain by optimising the search criteria. Moreover, it serves to bridge to future research by identifying gaps in the field.

Recommendation systems are a fundamental tool for hotels to adopt a differentiating competitive strategy. The main purpose of this work is to use machine learning techniques to treat imbalanced data sets, not applied until now in the tourism field. These techniques have allowed the authors to analyse the influence of imbalance data on hotel recommendation models and how this phenomenon affects client dissatisfaction.

An opinion survey was conducted among hotel customers of different categories in 120 different countries. A total of 135.102 surveys were collected over eleven quarters. A longitudinal design was conducted during this period. A binary logistic model was applied using the function generalized lineal model (GLM).

Through the analysis of a representative amount of data, the authors empirically demonstrate that the imbalance phenomenon is systematically present in hotel recommendation surveys. In addition, the authors show that the imbalance exists independently of the period in which the survey is done, which means that it is intrinsic to recommendation surveys on this topic. The authors demonstrate the improvement of recommendation systems highlighting the presence of imbalance data and consequences for marketing strategies.

The main contribution of the current work is to apply to the tourism sector the framework for imbalanced data, typically used in the machine learning, improving predictive models.

The purpose of this paper is to analyse the future of the implementation of artificial intelligence (AI) technologies in services experience provided by cultural institutions (e.g. museums, exhibition halls and cultural centres) from experts’, cultural tourists’ and users’ point of view under the Industry 5.0 approach.

The research was conducted using a qualitative approach, which was based on the analysis of the contents obtained from two roundtable discussions with experts and cultural tourists and users. A thematic analysis using NVivo was done to the data obtained.

From a futuristic Industry 5.0 approach, AI is considered to be more than a tool – it as an integral part of the entire experience. AI aids in connecting cultural institutions with users and is beneficial since it allows the institutions to get to know the users better and provide a more integrated and immersive experience. Furthermore, AI is critical in establishing a community and nurturing it daily.

The most important contribution of this research is the theoretical model focused on the user experience and AI application in services experiences of museums and cultural institutions from an Industry 5.0 approach. This model includes the visitors’ and managers’ points of view through the following dimensions: the pre-experience, experience and post-experience. This model is focused on human–AI coworking (HAIC) in museums and cultural institutions.

Motivated by a lack of evidence regarding the effect of migration on entrepreneurship in a highly informal country, such as Colombia, this paper has a twofold purpose. First, it explores how Venezuelan immigration affects entrepreneurial activity in Colombian regions. Second, it intends to shed light on this relationship, by distinguishing between formal and informal sectors.

With a sample of 1,776,063 individuals, from the Labor Survey Gran Encuesta Integrada de Hogares (GEIH) from the Departamento Administrativo Nacional de Estadística (DANE), the authors employ an instrumental variable approach to account for the selection of immigrants into locations with more or less desirable conditions.

The results suggest Venezuelan immigration positively influences self-employment and own-account workers, but negatively affects employers. However, once these immigrants proliferate in the informal sector, the effects increase.

This paper brings new insights into the intersection between immigration, unofficial economies, and entrepreneurship. First, while the prior literature focuses on migration from developing to developed countries, migratory flows between developing economies and its effects on local entrepreneurial activity remain unexplored. Second, although informality is mostly common in developing countries, little (albeit growing) evidence of its role in the relationship between migration and entrepreneurship research exists. Finally, the authors bring together these two phenomena to enhance our understanding of different types of entrepreneurial activities when immigration and informality take place. Policy implications are derived from these insights.

The purpose of this paper is to shed light on the state-of-the-art about sustainable tourism. Despite the significant growth of publications exploring sustainable tourism, the debate on the relationship between tourism and sustainability remains open. In addition, the sector faces the challenge of the 2030 Agenda, as the authors have not yet managed to curb environmental degradation and social disparities. This research needs to be comprehensively addressed to inform future steps and to identify sustainable tourism practices that will advance the goals of this action plan.

This study applies a mixed methodology, using a bibliometric analysis performed by VOSviewer and SciMat software of 311 articles from the Web of Science. In addition, it includes an in-depth analysis of trending research topics in the field during 2019 and 2020.

After 20 years of research on sustainable tourism, there is still significant dispersion of studied topics, frameworks and applications. The results show the evolution of research towards the study and measurement of sustainable change, social and cultural aspects and the development of responsible governance models.

New stakeholder relationships models require a methodological and technological framework. Further progress in sustainable tourism guided by the 2030 Agenda demands the establishment of worldwide recognised measurement indicators and policy frameworks.

With a mixed methodological approach and a special focus on the sustainable development goals (SDGs), this paper provides a “state-of-the-art” update to sustainability research in tourism. The results obtained have been associated with their contribution to achieving SDGs.

尽管探索可持续旅游业的出版物大幅增长, 但关于旅游业和可持续性之间关系的辩论仍然没有结束。此外, 该部门还面临着2030年议程的挑战, 因为我们还没有设法遏制环境退化和社会差异。这项研究需要全面解决, 以便为未来的步骤提供信息, 并确定可持续旅游的做法, 以推进本行动计划的目标。

本研究采用混合方法, 通过VOSviewer和SciMat软件对来自科学网的311篇文章进行文献计量分析。此外, 它还包括对2019年和2020年期间该领域的趋势性研究课题的深入分析。

经过20年的可持续旅游研究, 所研究的课题框架和应用仍然存在很大的分散性。我们的结果显示, 研究朝着研究和测量可持续变化、社会和文化方面以及发展负责任的治理模式的方向发展。

新的利益相关者关系模型需要一个方法学和技术框架。在2030年议程的指导下, 可持续旅游业的进一步发展需要建立世界公认的测量指标和政策框架。

通过混合方法和对可持续发展目标（SDGs）的特别关注, 本文为旅游业的可持续性研究提供了 “最先进 “的更新。获得的结果与他们对实现可持续发展目标的贡献有关。

A pesar del importante crecimiento de las publicaciones que exploran el turismo sostenible, el debate sobre la relación entre turismo y sostenibilidad sigue abierto. Además, el sector se enfrenta al reto de la Agenda 2030, ya que aún no se ha conseguido frenar la degradación medioambiental y las disparidades sociales. Esta investigación debe abordarse de forma exhaustiva para informar de los pasos futuros e identificar las prácticas de turismo sostenible que harán avanzar los objetivos de este plan de acción.

Este estudio aplica una metodología mixta, utilizando un análisis bibliométrico realizado por el software VOSviewer y SciMat con 311 artículos de la Web of Science. Además, incluye un análisis en profundidad de los temas de investigación de tendencia en el campo durante 2019 y 2020.

Después de 20 años de investigación sobre el turismo sostenible, sigue habiendo una importante dispersión de los marcos temáticos estudiados y de las aplicaciones. Nuestros resultados muestran la evolución de la investigación hacia el estudio y la medición del cambio sostenible, los aspectos sociales y culturales y el desarrollo de modelos de gobernanza responsable.

Los nuevos modelos de relaciones con los grupos de interés requieren un marco metodológico y tecnológico. Los nuevos avances en el turismo sostenible guiados por la Agenda 2030 exigen el establecimiento de indicadores de medición y marcos políticos reconocidos a nivel mundial.

Con un enfoque metodológico mixto centrado especialmente en los Objetivos de Desarrollo Sostenible (ODS), este trabajo proporciona una actualización del “estado del arte” a la investigación de la sostenibilidad en el turismo. Los resultados obtenidos se han asociado con la consecución de los ODS.

This study aims to investigate how university students experience a skill transformation process aligned with the sustainable development goals (SDGs). This transformation occurs through their participation in a service-learning programme alongside an international volunteering project. The theoretical framework for understanding this skill transformation process is based on the “rite of passage”.

Qualitative methodology is adopted by conducting 23 online surveys with volunteers (virtual and onsite) and five with coordinators across the rite of passage phases. Volunteering was carried out in five Mayan indigenous communities in Mexico as part of an international cooperation project with the goals of supporting community-based tourism development and strengthening volunteers’ skills in accordance with the SDGs.

Results show that international volunteering programmes for university students significantly enhance their interpersonal and professional skills, demonstrating strong potential for implementing the SDGs. These programmes provide learning and education opportunities for both volunteers and local communities. Volunteers gain a broader perspective on gender equality and cultural barriers. Additionally, volunteering supports sustainable tourism, economic worth and collaboration among institutions. Both volunteers’ personal characteristics (educational level and sociocultural context), as well as their sociocultural context, influenced the perception of the skill transformation process and learning about the SDGs. Finally, a new educational university programme in volunteering aligned with SDGs is proposed.

This research examines the practical ramifications of incorporating volunteer programmes into university courses. Universities must include these initiatives in their educational systems as a means of enhancing student learning.

A new educational university programme in volunteering aligned with SDGs is proposed. This study suggests a shift in university mindset, as well as increased funding for training and adherence to the SDGs.

This study pioneers the rite of passage framework in an international volunteer tourism project facilitated by universities, emphasizing volunteering as a valuable tool for SDG implementation, considering the interrelationships between objectives.

This paper aims to define the efficiency achieved by urban transport companies in Spain concerning the resources they use, considering the type of management used for implementation, public-private, and size.

This study consisted of an analysis of the efficiency of 229 public-private urban transport operators during the period 2012–2021 using Data Envelopment Analysis, the Malmquist Index and inference estimators to determine productivity, efficiency change into Pure Technical Efficiency Change (PTECH), and scale efficiency change.

Based on the efficiency analysis, the authors concluded that of the 229 companies studied, more than 35 were inefficient in all analysed periods. Considering the sample used, direct management is considered significantly more efficient. It cannot be concluded that the size of these companies influences their efficiency, as the data show unequal development behaviours in the studied years.

This study provides arguments on whether there is a significant difference between the two types of management in the urban transport sector. It also includes firm size as a study variable, which has not been previously considered in other studies related to urban transport efficiency. Efficiency should be a crucial factor in determining funding allocation in this sector, as it encourages operators to optimize and improve their services.