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Increased evidence for the health benefits of probiotics for health restoration coupled with the consumer's inclination towards a safe, natural and cost-effective substitute for drugs have led application of probiotics as a pharmaceutical agent and are rapidly moving in clinical usage. In this context, this article attempts to highlight the potential of probiotics as a pharmaceutical agent.

Endeavor has been made to explore the significance of probiotics for the modulation of gut ecology and their action. Potentiality of probiotics for their exploitation as a pharmaceutical agent has also been justified. Limitations of probiotic therapy and the various considerations for probiotic therapy have also been delineated.

Probiotic organisms influence the physiological and pathological process of the host by modifying the intestinal microbiota, thereby affecting human health. Beneficial effects of probiotics as a pharmaceutical agent seem to be strain and dose dependent and more efficacious with their early introduction. Combination of various probiotics proved to be more efficacious than single strain for exhibiting prophylactic activities.

Reviewed literature indicated that it is difficult to generalize for the beneficial effect of all probiotics for all types of diseases as efficacy of probiotics is strain-dependent and dose-dependent and its clinical application needs long-term investigations.

Clinical trials have displayed that probiotics may alleviate certain disorders or diseases in humans especially those related to gastro-intestinal tract.

Ingestion of fermented dairy products containing probiotic cultures may provide health benefits in certain clinical conditions such as antibiotic-associated diarrhoea, rotavirus-associated diarrhoea, inflammatory bowel disease, inflammatory bowel syndrome, allergenic diseases, cancer, Helicobacter pylori infection and lactose-intolerance. Application of probiotics as a pharmaceutical agent is recommended.

The majority of peptic ulcers are associated with Helicobacter pylori infection and it is now clear that eradication of H. pylori dramatically reduces ulcer recurrence. Other important outcomes of H. pylori infection include chronic gastritis (which may be asymptomatic), gastric cancer and lymphoma. Aims to give a brief overview of the discovery, epidemiology, pathophysiology, diagnosis and treatment of H. pylori associated disease.

The purpose of this review is to address the consumer’s preferences that have varied greatly in the past decade appraising the use of flavor and aroma compounds in the development of functional foods rather than consuming artificial additives. A growing interest in natural flavoring agents and preservatives have made the researchers to explore the other bio-functional properties of natural flavors beyond their ability to give a remarkable flavor to the food.

In this review, five major flavoring agents used significantly in food industries have been discussed for their bioactive profile and promising health benefits. Vanilla, coffee, cardamom, saffron and cinnamon, despite being appreciated as natural flavors, have got impressive health benefits due to functional ingredients, which are being used for the development of nutraceuticals.

Flavoring and coloring compounds of these products have shown positive results in the prevention of several diseases including carcinoma and neurological diseases such as Alzheimer’s and Parkinson’s. Such effects are attributed to the presence of phenolic compounds, which possesses free radical scavenging, anti-inflammatory antiviral and antimicrobial properties. These properties not only show a preventive mechanism against diseases but also makes the food product shelf-stable by imparting antimicrobial effects.

This paper highlights the opportunities to increase the use of such natural flavoring agents over synthetic aroma compounds to develop novel functional foods. Phenols, carotenoids and flavonoids are the major health-promoting components of these highly valued aroma ingredients.

Introduction Clinical Guidelines are systematically developed statements which assist clinicians and patients in making decisions about appropriate treatment for specific conditions. While there have been great expectations of improving clinical practice many criticisms of the process have been made:

The purpose of this paper is to evaluate the possible relationship of dietary glycemic index (GI) and glycemic load (GL) with ulcerative colitis (UC) risks because there is insufficient evidence on the association of GI and GL with UC incidences.

In this case–control study, dietary GI and GL of 62 patients with histology-confirmed UC and 124 controls were assessed using a validated semi-quantitative food frequency questionnaire. The primary outcome measure was the association between dietary GI and GL and UC risk.

In age-adjusted and unadjusted models, there was no statistically significant association between dietary GI and GL and UC risk. However, after adjusting for all known covariates, the odds ratio of UC in third tertile of GI was 2.86 folds higher than first tertile (95% CI: 1.02–8.00, p for trend = 0.04). In the case of GL, when the confounders were adjusted, although subjects in the third tertile were at 2.70 times higher risk of having UC than those in the first tertile (95% CI: 0.72–10.15, p for trend = 0.15), the association was not statistically significant.

In conclusion, the findings indicate a positive relationship between dietary GI and risk of UC. Further prospective studies are needed to elucidate if the findings are consistent, in addition to experimental studies to explore the potential mechanisms of this association.

This study investigated the anthropomorphism of the pandemic virus and its downstream effects by examining how warnings trigger viewers' risk perceptions and motivate them to pursue protection.

Three experiments were conducted. The first was a two-part (virus: anthropomorphic vs non-anthropomorphic) between-subject design that measured the participants' risk perception and compliance intention. The second experiment used a three-part (cuteness: cute vs non-cute vs control) between-subjects design. The third experiment used a three-part (cuteness: cute vs non-cute vs control) by two-part (aggressive guidance: present vs absent) between-subject design.

Anthropomorphism of the virus increased risk perception, thus influencing protective behavior and the effectiveness of warning signs, but only when the message was not perceived as cute. Aggressive messages and cute images of baby schemata enhanced compliance intention to warning guidelines.

The results provide a theoretical basis for studying the effectiveness of anthropomorphized warning signs and suggest implications for the impact of anthropomorphism on risk communication and compliance.

This study highlights that cuteness, often accompanied by anthropomorphism, may evoke inferences that reduce the effect of risk communication to induce compliance intention. Furthermore, the authors discovered that a more persuasive message appeals to mitigate the maladaptive responses to cute warnings.

Mushrooms have always been treasured and appreciated, thanks to their nutritional as well as medicinal properties. The purpose of this paper is to reveal these properties such as antioxidant activities and enzyme inhibition potentials of three mushroom species from Ordu, Turkey. Furthermore, phenolic profiles which are believed to be source of these properties are investigated.

The assays followed to determine total phenolic, flavonoid and antioxidant contents, antioxidative and enzyme inhibition activities are spectrophotometric methods. Phenolic profiles of mushroom samples were investigated by using the HPLC system.

The highest phenolic content was found for Lactarius deliciosus. Pyrogallol was the major phenolics in all three samples. Total phenolic content values supported that finding. But, total flavonoid content was the maximum for Cantharellus cibarius. The magnitude of the antioxidant activities revealed by the different tests varied between species. Furthermore, inhibition potential degrees on acetylcholinesterase, butrylcholinesterase, tyrosinase and urease activities were worth mentioning. Lactarius pyrogalus had anti-tyrosinase activity with a 26.229 percent inhibition rate. IC₅₀ values for urease inhibition effect of mushroom samples were in the range of 0.37–0.90 mg/mL.

Enzyme inhibitory potentials for L. pyrogalus was revealed first time. On the other hand, studies on anti-tyrosinase activity of mushrooms are very rare, while almost no studies have been conducted on anti-urease activity. So, the results of present study are very valuable. Thus, the obtained data not only increase the ecological importance of the region but also provide significant contributions to the literature in terms of new sources rich in antioxidants.

Despite the significant amount of time that children spend in the home, relatively little attention has been paid to the direct impact of housing conditions on children's development. A literature review of over 100 research studies was undertaken to examine evidence of a ‘housing effect’ on children's health, learning, safety and behaviour. The results found strong evidence of a relationship between poor housing conditions and children's health and some evidence that growing up in sub‐standard housing affects children's performance at school. While children's safety is clearly linked to the quality of their home environment, further research is necessary to understand the apparent link between poor housing conditions and children's behavioural problems. The review suggests that growing up in poor housing has a profound and long‐term effect on children's life chances and that public policy should play closer attention to this relationship. Nevertheless, the volume of high‐quality research in this area is surprisingly limited and there is a need for more comprehensive studies.