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The paper's purpose is to document a clinical study of children with Henoch‐Schonlein Purpura that facilitated decision‐making with regard to investigations, follow up and timely referral to a nephrologist.

A retrospective analysis of clinical records of 33 children diagnosed with Henoch‐Schonlein purpura who attended the Whiston Hospital Paediatric unit over a 60‐month period between January 2001 and December 2005 was performed.

In the study 53 per cent (n 17) of the patients were boys. The commonest age group affected was between five to ten years (n 17), with mean age of 7.2 years (range 1 to 17 years). Of the cases , 71 per cent (n 22) presented between July and December. Four patients (13 per cent) had haematuria on dipstick examination at presentation. Eight patients (25 per cent) had neither blood pressure measurement on admission nor a documented plan for urine dipstick or blood pressure measurement on discharge. Daily urine dipstick was performed in 47 per cent (n 15) patients with one patient having checks twice a week. Information to parents was not documented in 72 per cent (n 23) of case notes.

The need to provide better parental education and support in the form of an information leaflet was identified.

This study highlights the importance of follow up of children with HSP with emphasis on regular urine dipstick examination and measurement of blood pressure even if they remain asymptomatic to ensure that they do not develop long‐term renal impairment.

Changes in regulations aiming at reducing the impact that technologies such as coatings, adhesives, cleaners have on the environment is leading to large advances in these end‐use technologies. In achieving the required quality of the end product, and irrespective of whether this is in areas such as high solids paints or water‐based coatings, solvents keep on playing an important role. At the same time different requirements are set for the solvents employed. The changing role of solvents and the technological benefits solvents are bringing are discussed. It is shown that the computer programme BLENDPRO is an effective reformulation tool which assists in the efficient development of new formulations in these areas.

Mixed fermentation with Saccharomyces cerevisiae and non-Saccharomyces yeasts has become an oenlogical tool to improve wines’ organoleptic properties. However, the maximum utilization of this method is dependent upon understanding the influence of mixed cultures on the physiology of S.cerevisiae and non-Saccharomyces yeasts.

In this study, the supernatants from 48 h mixed-culture fermentation were added to the pure cultures of Issatchenkia orientalis and Saccharomyces, respectively. And the authors used RNA sequencing to determine the transcriptome change of I.orientalis and S.cerevisiae in a mixed culture.

The results showed that multiple genes associated with cell growth and death were differentially expressed. Genes related to biosynthesis of amino acids were enriched among those upregulated in the mixed-fermentation supernatant. Meanwhile, the differential expression level of genes encoding enzymes essential for formation of aroma compounds was found in the single and in the mixed fermentation. The high expression level of molecular chaperones Hsp70, Hsp90 and Hsp110 suggests that metabolites of mixed-culture fermentation may lead to aggregation of misfolded proteins. Moreover, upregulation of ethanol dehydrogenase I ADH1 in the mixed-culture fermentations was highlighted.

This is the first time that RNA-seq was used to analyze changes in the transcriptome of mixed cultures. According to the results the authors’ manuscript provided, an integrated view into the adaptive responses of S.cerevisiae and non-Saccharomyces yeasts to the mixed-culture fermentation is benefit for the potential application of S.cerevisiae and non-Saccharomyces yeasts in fruit wine brewing.