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According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR, American Psychiatric Association (APA), 2000), autistic spectrum disorders (ASD) are a collection of chronic conditions that include Autistic Disorder, Rett's Disorder, Childhood Disintegrative Disorder, Aspeger's Disorder, and Pervasive Developmental Disorder Not Otherwise Specified. Typically, ASD are often identified during infancy or the toddler years. Most individuals with ASD have some degree of mental retardation. According to Deisinger (2001), genetic factors, abnormalities in brain structure and biochemistry, and complications during pregnancy have been implicated as possible causes of these disorders. Generally, students with ASD have difficulties with daily activities such as language, self-care, mobility, and independent functioning. The focus of this chapter examines the many features that must be considered before diagnosing and classifying individuals with ASD.