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The purpose of this paper is to estimate the influence of long‐term, whole‐body exposure of rats to strong, static electric field with physical parameters generated nearby high voltage direct current (HVDC) transmission lines on the intensity of reactive oxygen species generation analyzed indirectly, basing on the measurement of malone dialdehyde level, as well as on the activity of enzymatic antioxidant defence system.

In rats exposed to static electric field with intensity of 16, 25 and 35 kV/m, respectively, or sham‐exposed eight hours daily for 56 days, in the obtained plasma, erythrocytes lysates and liver homogenates the activity of some antioxidant enzymes as well as the concentration of malone dialdehyde were determined with use of spectrophotometric and kinetic methods.

It was observed that long‐term exposure of rats to static electric field causes only temporary compensatory changes in the concentration of malone dialdehyde and transient changes in the activity of enzymatic antioxidant system, both in blood and in liver tissue in the form of temporary inhibition of activity of most antioxidant enzymes during exposure cycle, with subsequent compensatory increase in this activity after the end of exposure cycle, enabling maintenance of prooxidant‐antioxidant balance in the organism of experimental animals and inhibition of peroxidation process.

Presented data indicate that construction of air HVDC transmission lines, according to actual compulsory regulations, enables serious health hazards related to persistent disturbances of prooxidant‐antioxidant balance to be avoided.

In the experiment it was confirmed, for the first time, that long‐term exposure to strong static electric field causes transient compensatory changes of prooxidant‐antioxidant balance in living organisms.

This study aims to investigate the possible effect of Citrus latifolia (CL) extract on biomarkers of oxidative stress, including lipid peroxidation products in rats fed a high cholesterol diet

Hypercholesterolemia was induced by feeding normocholesterolemic rats 1 per cent cholesterol-enriched diet for 15 days. An experimental group (n = 20) was divided into two groups (n = 10) and fed the same diet with or without CL lyophilized aqueous extract (1 per cent) for four weeks. At day 28, ten rats from each group were killed.

Treatment with CL lyophilized aqueous extract compared with the untreated group had decreased plasma total cholesterol (TC) (−36 per cent), triacylglycerols (−48 per cent), isoprostanes values (−74 per cent) and reduced thiobarbituric acid reactive substances in erythrocytes (−21 per cent). However, the supplementation of CL peels in the hypercholesterolemic diet enhanced superoxide dismutase (+69 per cent), glutathione reductase (+30 per cent) and catalase activities (+34 per cent).

In hypercholesterolemic rats, administering CL extract ameliorates dyslipidemia and attenuates lipid peroxidation in tissues. These results suggest that CL could be beneficial in the primary treatment of hypercholesterolemia and oxidative damage caused by a high-cholesterol diet.

This paper aims to study the effects of Zygophyllum album (Za) (Z. album) in hypercholesterolemic-diabetic rats.

Male Wistar rats (n = 36) weighing 200 ± 10 g, consumed an experimental diet containing 20 per cent casein were divided into three groups (n = 12). The first group consumed the diet enriched with 1 per cent cholesterol (CH), the second group is rendered diabetic by intraperitoneal injection of streptozotocin (STZ) (35 mg/kg body weight) (D) (DM). The third group is hypercholesterolemic and STZ-induced diabetic (CH-DM); each group was subdivided into two groups (n = 6), non-treated groups (CH, DM and CH-DM) and treated groups supplemented with 1 per cent Z. album lyophilized aqueous extract (CH-Z, DM-Z and CH-DM-Z).

In CH-DM group, Z. album decreases glycemia (−15 per cent) and inversely increases insulinemia (+28 per cent) and Homeostasis Model Assessment of Insulin Resistance (+19 per cent). In liver, total cholesterol (TC) and triacyglycerols (TAG) levels were reduced by −57 per cent and −29 per cent, respectively. In plasma, TC concentration was increased by +20 per cent, whereas those of TAG level were lowered by −56 per cent. Lecithin cholesterol acyl transferase and paraoxonase 1 activities were raised by +45 and +59 per cent, respectively. Inversely, thiobarbituric acid reactive substance levels were lowered significantly in liver, heart, kidney and adipose tissue (p < 0.05). Superoxide dismutase activity was enhanced in liver (+54 per cent), heart (+36 per cent), kidney (+45 per cent) and adipose tissue (59 per cent). Liver glutathione peroxidase (GSH-Px) activity was enhanced by +38 per cent and heart activities of GSH-Px, and glutathione reductase (GSSH-Red) were increased by +25 and +18 per cent. In kidney, GSH-Px activity was reduced by −26 per cent; in reverse, GSSH-Red activity was increased by +14 per cent. In adipose tissue, GSH-Px and GSSH-Red activities were augmented by +35 and +15 per cent.

These results suggest that Z. album aqueous extract has antihyperglycemic and antihyperlipemic actions. Also, Z. album protects against tissue oxidative damage; therefore, it can help to prevent cardiovascular complications of diabetes combined with hypercholesterolemia.

This study aims to analyze the antioxidant properties of the Mediterranean diet and describe methods that are used in clinical studies to assess its role in reducing oxidative stress.

The review presents the results of interventional and observational clinical trials aimed at assessing the influence of the Mediterranean diet on the level of enzymatic and non-enzymatic antioxidants, as well as the total blood antioxidant capacity.

The Mediterranean diet as a varied diet can be a better way to provide antioxidants to the body than supplements. Individual compounds administered in an isolated form can give the opposite effect to the expected, stimulating oxidative stress. The administration of antioxidants in the form of supplements instead of a varied diet is also associated with a lack of synergism of action. In studies on the importance of the Mediterranean diet in the reduction of oxidative stress, single markers are used to measure oxidative damage, the activity of enzymatic antioxidants and the concentration of individual non-enzymatic antioxidants. At the same time, the need to find markers that would assess the level of oxidative stress and the body’s antioxidant capacity more comprehensively is emphasized.

It should be taken into account that differences between in vivo and in vitro results may result from the fact of various factors, including genetic, smoking, intestinal microflora or diet composition. It is also necessary to answer the question about which marker or set of markers could in the most comprehensive way to assess the level of oxidative stress and the body’s antioxidant capacity.

The literature review shows not only the source of antioxidants in the Mediterranean diet. This paper also presents a critical approach to markers that allow the assessment of the antioxidant properties of the diet.

The purpose of this paper is to investigate the restoration effect of camel's milk against methoxychlor induced liver toxicity.

The present study was carried out to investigate the restoration effect of camel's milk against methoxychlor induced liver toxicity.

Methoxychlor (MXC) caused a significant increase in serum transaminases (aspartate transaminase and alanine transaminase) and alkaline phosphatase, while MXC induced a significant reduction in total protein and albumin levels. MXC significantly inhibited lipid peroxidation and markedly enhanced glutathione in liver homogenate. Pathological damages as degeneration and coagulative necrosis of hepatocytes were established in liver. Newly formed bile ducteules denotes neoplastic changes in the portal tract with abnormal mitotic pattern were associated with the long-term exposure.

The present study concluded that camel milk treatment may play a protective role against methoxychlor-induced liver damage in rats.

This paper aims to depict the mechanistic role of vitamin D on dementia prevention, relief of the severity and the complication of the disease. All papers indexed in scientific databases, including Scopus, Elsevier, PubMed, Embase and Google Scholar between 2000 and 2021 were extracted and discussed. To present the mechanistic role of vitamin D in declining the severity of dementia, keywords including dementia, vitamin D, oxidative stress, inflammation, amyloid beta-Peptides were used.

Dementia is a prevalent cognitive disorder worldwide, especially in elderly people, which is accompanied by serious disabilities. Besides genetic, biological and lifestyle factors are involved in the incidence of dementia. An unhealthy diet along with micronutrient deficiencies are among modifiable factors. Vitamin D is one of the important micronutrients in brain health. Besides the involvement in gene expression, bone mineralization, apoptosis, inflammation, skeletal maturation, neurotropic action and hemostasis of phosphate and calcium, vitamin D also exerts neuroprotective effects via genomic and non-genomic pathways.

Vitamin D up-regulates the expression of various genes involved in dementia incidence via various mechanisms. Decreasing oxidative stress and the neuro-inflammatory cytokines levels, regulation of the expression of alternated Proteins including Tau and Amyloid-ß, calcium homeostasis in the central nervous system and also vascular are considered main mechanisms.

Considering the importance of diet in preventing dementia, adherence to a healthy diet that provides essential nutrients to brain function seems to be urgent. Controlling serum levels of vitamin D periodically and providing vitamin D by related sources or supplements, if there is a deficiency, is recommended. Future studies are needed to clarify other related mechanisms.

White tea is an unfermented tea made from young shoots of Camellia sinensis protected from sunlight to avoid polyphenol degradation. White tea contains a high level of polyphenolic compounds known as catechins. Several types of evidence have suggested that tea consumption has benefits in body weight and endurance maintenance. This study was designed to evaluate the effect of white tea on body weight and endurance of animal models.

This research was an intervention design using 20 Wistar white rats (Rattus Norvegicus) in body weight between 150 and 200 g. The rats were randomized into four groups, three groups receiving white tea drink (WTD) with different doses and the other group receiving plain water in equal volume as a control group for four weeks. The forced swim test (FST) was done to measure their struggling capacity, and digital bodyweight to measure the weight.

Intervention (WTD Groups and Control) caused weight gain among except G3 with the highest doses of white tea. The result showed that WTD intake in G3 had a significant difference (p < 0.05) on body weight gain compared to control. The authors found that WTD in a specific dose (G3: 0.22 mg) tends to maintain the body weight of animals (219.2 ± 41.96; 212.6 ± 46.90, respectively), while other doses caused weight gain. WTD also significantly increased the swimming and struggling capacity of rats that represented improvements the endurance along with the test. There was a statistically significant difference in endurance among all groups (p < 0.05).

The results of this study can be followed as human intervention research as an input for nutritionists and sports scientists to explore the beneficial effect of white tea.

The results of this study can be followed as human intervention research as an input for nutritionists and sports scientists to explore the beneficial effect of white tea.

This study adds more evidence and information about the advantages of white tea as potential beverages in future healthy lifestyles.

This research intended the utilization of Javanese turmeric (0.4% w/v) as a kombucha substrate and analysis of its hepatoprotective activity, in comparison against nonfermented Javanese turmeric beverage (JTB) and black tea kombucha.

Forty-two healthy male Balb/c mice (two- to three-week-old, 20–30 g) were divided into six groups with seven replicates each. The treatments were normal diet, normal diet + Javanese turmeric kombucha (JTK), normal diet + diethylnitrosamine (DEN), DEN + JTB, DEN + JTK, DEN + black tea kombucha. Kombuchas and JTB were given at 0.3 mL/20 g BW/d. DEN was induced intraperitoneally at a dose of 100 mg/kg. Observed biomarkers were blood serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activity, serum malonaldehyde (MDA), as well as liver histology. Data were analyzed using analysis of variance.

Among DEN-induced groups, JTK significantly (p < 0.05) diminished the level of blood SGPT, SGOT and serum MDA. JTK also had lower blood SGPT (8.604 ± 2.195 U/L) and serum MDA levels (2.884 ± 0.083 nM/mL) compared to the normal group (8.604 ± 2.195 U/L and 5.050 ± 0.998 nM/mL, respectively). JTK also produced the least damaged liver-cell numbers.

JTK demonstrated better hepatoprotective activity compared to JTB.

This study aims to examine the effects of various physical and chemical pre-treatments on antioxidant properties of tree bean (Parkia roxburghii G. Don) in combination with storage conditions.

The whole pods and seeds of tree bean were treated with gamma rays (γ-rays), sodium hypochlorite (NaOCl), chlorine dioxide (ClO₂) and hydrogen peroxide (H₂O₂) and stored at room temperature (RT, 25°C) for 30 days. The physical and chemical pre-treated seeds and pods were compared with the same stored at RT and refrigerated storage at 4°C and −20°C. During storage, physical (moisture content) and antioxidants like total phenolics, ascorbate content, reduced glutathione, total flavonoids, along with free radical scavenging activities (FRSA) were measured.

Chemical pre-treatments with NaOCl, ClO₂ and H₂O₂ significantly accelerated (p = 0.05) the total phenolics (1.9 mg/g FW in seeds and 2.4 mg/g FW in pods), flavonoids content (0.3 mg/g FW each in seeds and pods) and ABTS activities (73.3 per cent in seeds and 92.3 per cent in pods) at 30 days of storage. A significant decrease (p = 0.05) in ascorbate content (6.1 mg/g FW in seeds and 3.5 mg/g FW in pods), reduced glutathione (5.1 mg/g FW in seeds and 3.7 mg/g FW in pods), FRAP (0.3 mg equi Fe/g FW in seeds and 0.4 mg equi Fe/g FW in pods) and reducing power (1.8 mg/g FW in seeds and 3.7 mg/g FW in pods) was observed under all the treatments at 30 days of storage. However, DPPH increased under γ-irradiation and decreased under chemical pre-treatments, storage at RT and refrigerated storage. The overall result showed that pre-treatment of H₂O₂ at 10-20 mM maintains antioxidants and radical scavenging activities in tree bean during storage.

The application of H₂O₂ at 10-20 mM prior to storage of tree bean maintains the physical, antioxidant properties and FRSA in tree bean seeds and pods as compared to natural ambient conditions. Hence, this technique will help in improving the keeping quality of this legume and avoid spoilage after harvest for an extended period.

Potato (Solanum tuberosum L. cv. Kara) was grown in Open‐Top Chambers (OTCs) in Northern Egypt at ambient (ca 350 ppm) or doubled CO₂ (ca 690 ppm) either in charcoal‐filtered air (15 nl l‐1) or in non‐filtered ambient air (78 nll‐1 O₃) to investigate the changes in physiology and yield under long‐term elevated CO₂ and/or O₃ throughout 100 days. Ambient O₃ level reduced net photosynthetic rates, number and weight of tubers by 18 per cent, 41 per cent and 21 per cent, respectively, whereas elevated CO₂ caused the opposite effect where it increased the same parameters by 44 per cent, 37 per cent and 20 per cent, respectively. Significant O₃ x CO₂ interactions were detected. However, O₃ caused an increase in GR and POD by 18 per cent and 35 per cent, respectively, while CO₂ caused an increase in POD only by 46 per cent, and there was no effect of O₃ and/or CO₂ on other enzymes. The results of this study are discussed in relation to predicted atmospheric changes.