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Umami (the so‐called fifth basic taste in addition to sweet, sour, salt and bitter) is the descriptive term given to glutamate found naturally in foods or added as the flavour‐enhancer monosodium glutamate, as well as other combinations of glutamate and nucleotides. Discusses natural sources of glutamate, as well as commercial production and uses of these flavour‐enhancers. Reviews legislation, thus providing a rounded up‐to‐date picture of this new and fascinating subject area.

Purpose – The objective of the present study was to determine the effect of monosodium glutamate (MSG) administration to pyramidal cells necrosis on the cerebral cortex of Wistar male rats (Rattus norvegicus).

Design/Methodology/Approach – This research was a laboratory quasi-experiment study with post-test control group design on 24 male Wistar rats (Rattus norvegicus) aged 8-10 weeks, weighted 200 ± 10 gr, divided into 4 groups (GI or control group, GII treated with MSG dose 6 mg/grbb/day, GIII 12 mg/grbb/day, and GIV 24 mg/grbb/day) for 21 days consecutively. Pyramidal cells observed in 10 field of view. The Kruskal-Wallis test and Mann Whitney tests were used to analyze the data.

Findings – There were significant differences between pyramidal cells necrosis numbers between control and the treatment groups. MSG doses 6, 12, and 24 mg/grbb/day developed the pyramidal cells necrosis in the cerebral cortex (p < 0,005).

The purpose of this paper is to investigate the body-mind problem from a mathematical invariance principle in relation to personality dynamics in the psychological and the biological levels of description.

The relationship between the two mentioned levels of description is provided by two mathematical models as follows: the response model and the bridge model. The response model (an integro-differential equation) is capable to reproduce the personality dynamics as a consequence of a determined stimulus. The invariance principle asserts that the response model can reproduce personality dynamics at the two levels of description. The bridge model (a second-order partial differential equation) can be deduced as a consequence of this principle: it provides the co-evolution of the general factor of personality (GFP) (mind), the it is an immediate early gene (c-fos) and D3 dopamine receptor gene (DRD3) gens and the glutamate neurotransmitter (body).

An application case is presented by setting up two experimental designs: a previous pilot AB pseudo-experimental design (AB) pseudo-experimental design with one subject and a subsequent ABC experimental design (ABC) experimental design with another subject. The stimulus used is the stimulant drug methylphenidate. The response and bridge models are validated with the outcomes of these experiments.

The mathematical approach here presented is based on a holistic personality model developed in the past few years: the unique trait personality theory, which claims for a single personality trait to understand the overall human personality: the GFP.

Higher education has struggled to find, implement, and adopt technology that is transformative to the learning experience. Most systems are disparate, old, data-poor, and heavily nuanced platforms with few champions and many detractors. At the same time, the process of learning, which is the ultimate goal of the institution’s students, does not leverage what we know about the brain, learning science, and more. However, all of these problems can be overcome if leaders and champions create learning technologies that are holistic to the student experience while assuring deep integration with other systems. This is how student success initiatives can be improved, at scale, and see technology assisting leaders.

Leveraging case studies of exemplar teaching, learning, technological, and data strategies by which to empower people and connect analytics, this chapter seeks to provide tangible ways by which to deliver “best” learning from a holistic perspective. The problems facing higher education and consistently presented in the media can be overcome with smarter, more connected solutions, such as the ones described in this chapter.

This research intended the utilization of Javanese turmeric (0.4% w/v) as a kombucha substrate and analysis of its hepatoprotective activity, in comparison against nonfermented Javanese turmeric beverage (JTB) and black tea kombucha.

Forty-two healthy male Balb/c mice (two- to three-week-old, 20–30 g) were divided into six groups with seven replicates each. The treatments were normal diet, normal diet + Javanese turmeric kombucha (JTK), normal diet + diethylnitrosamine (DEN), DEN + JTB, DEN + JTK, DEN + black tea kombucha. Kombuchas and JTB were given at 0.3 mL/20 g BW/d. DEN was induced intraperitoneally at a dose of 100 mg/kg. Observed biomarkers were blood serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activity, serum malonaldehyde (MDA), as well as liver histology. Data were analyzed using analysis of variance.

Among DEN-induced groups, JTK significantly (p < 0.05) diminished the level of blood SGPT, SGOT and serum MDA. JTK also had lower blood SGPT (8.604 ± 2.195 U/L) and serum MDA levels (2.884 ± 0.083 nM/mL) compared to the normal group (8.604 ± 2.195 U/L and 5.050 ± 0.998 nM/mL, respectively). JTK also produced the least damaged liver-cell numbers.

JTK demonstrated better hepatoprotective activity compared to JTB.

Gamma-aminobutyric acid (GABA) is a four-carbon and nonprotein amino acid, made by various microorganisms, especially lactic acid bacteria (LAB) and probiotics. GABA has various physiological roles, for instance, insomnia, depression, hypotensive activity as well as diuretic effects. The production of GABA-based foods is a favorable result from GABA’s biological and functional properties. The purpose of this study is to investigate different methods of improving GABA production in probiotics and LAB to select the superlative method and bacterial strain.

In this review paper, all articles from five electronic databases containing Google Scholar, Web of Science, PubMed, Scopus and Science Direct were considered from 2000 to January 11, 2023, with keywords “Optimization” OR “Enhance” OR “Increase” AND “Gamma-aminobutyric acid” OR “GABA” AND “Probiotics” OR “Lactic acid bacteria” and selected according to the purpose of the study.

It seems that among all the investigated methods, an effective fermentation procedure with optimal conditions including fermentation medium, 5 L; glutamic acid, 295 g/L; incubation temperature, 32°C; inoculum, 10% (v/v); and agitation, 100 rpm, after 48 h of fermentation led to producing 205,800 mg/L of GABA from the effective bacterial strain Lactobacillus brevis NCL912.

With a simple but optimized fermentation, L. brevis NCL912 can be used for the efficient GABA production in the pharmacy and food factories.

It tends to be called the corner shop, mainly because it occupied a corner building for extra window space, but also due to the impetus given to the name by television series seeking to portray life as it used to be. The village grew from the land, a permanent stopping place for the wandering tribes of early Britain, the Saxons, Welsh, Angles; it furnished the needs of those forming it and eventually a village store or shop was one of those needs. Where the needs have remained unchanged, the village is much as it has always been, a historical portrait. The town grew out of the village, sometimes a conglomerate of several adjacent villages. In the days before cheap transport, the corner shop, in euphoric business terms, would be described as “a little gold mine”, able to hold its own against the first introduction of multiple chain stores, but after 1914 everything changed. Edwardian England was blasted out of existence by the holocaust of 1914–18, destroyed beyond all hope of recovery. The patterns of retail trading changed and have been continuously changing ever since. A highly developed system of cheap bus transport took village housewives and also those in the outlying parts of town into busy central shopping streets. The jaunt of the week for the village wife who saw little during the working days; the corner shop remained mainly for things they had “run out of”. Every village had its “uppety” madames however who affected disdain of the corner shop and its proprietors, preferring to swish their skirts in more fashionable emporia, basking in the obsequious reception by the proprietor and his equally servile staff.

The management of individuals with autism spectrum disorders (ASDs) requires a multimodal approach of behavioural, educational and pharmacological treatments. At present, there are no available drugs to treat the core symptoms of ASDs and therefore a wide range of psychotropic medications are used in the management of problems behaviours, co-occurring psychiatric disorders and other associated features. The purpose of this paper is to map the literature on pharmacological treatment in persons with ASD in order to identify those most commonly used, choice criteria, and safety.

A systematic mapping of the recent literature was undertaken on the basis of the following questions: What are the most frequently used psychoactive compounds in ASD? What are the criteria guiding the choice of a specific compound? How effective and safe is every psychoactive drug used in ASD? The literature search was conducted through search engines available on Medline, Medmatrix, NHS Evidence, Web of Science and the Cochrane Library.

Many psychotropic medications have been studied in ASDs, but few have strong evidence to support their use. Most commonly prescribed medications, in order of frequency, are antipsychotics, antidepressants, anticonvulsants and stimulants, many of them without definitive studies guiding their usage. Recent animal studies can be useful models for understanding the common pathogenic pathways leading to ASDs, and have the potential to offer new biologically focused treatment options.

This is a practice review paper applying recent evidence from the literature.