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Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies have focused on risk associated with single variants, a strategy which has so far only yielded small (often non-replicable) risks for depressive disorders. In this paper we argue that more substantial risks are likely to emerge from genetic variants acting in synergy within and across larger neurobiological systems (polygenic risk factors). We show how knowledge of major integrated neurobiological systems provides a robust basis for defining and testing theoretically defensible polygenic risk factors. We do this by describing the architecture of the overall stress response. Maladaptation via impaired stress responsiveness is central to the aetiology of depression and anxiety and provides a framework for a systems biology approach to candidate gene selection. We propose principles for identifying genes and gene networks within the neurosystems involved in the stress response and for defining polygenic risk factors based on the neurobiology of stress-related behaviour. We conclude that knowledge of the neurobiology of the stress response system is likely to play a central role in future efforts to improve genetic prediction of depression and related disorders.

Diabetes is a major metabolic disorder which can affect entire body system adversely. Undiagnosed diabetes can increase the risk of cardiac stroke, diabetic nephropathy and other disorders. All over the world millions of people are affected by this disease. Early detection of diabetes is very important to maintain a healthy life. This disease is a reason of global concern as the cases of diabetes are rising rapidly. Machine learning (ML) is a computational method for automatic learning from experience and improves the performance to make more accurate predictions. In the current research we have utilized machine learning technique in Pima Indian diabetes dataset to develop trends and detect patterns with risk factors using R data manipulation tool. To classify the patients into diabetic and non-diabetic we have developed and analyzed five different predictive models using R data manipulation tool. For this purpose we used supervised machine learning algorithms namely linear kernel support vector machine (SVM-linear), radial basis function (RBF) kernel support vector machine, k-nearest neighbour (k-NN), artificial neural network (ANN) and multifactor dimensionality reduction (MDR).