Search results

The purpose of this paper is to assess whether China’s public sector can continue to generate advanced genetically modified (GM) technologies that will be competitive in the market.

The authors investigated all the research teams that have been conducting research projects under the variety development special program. The data collected include detail information on research capacity, research areas, performance, and process of their research projects. Based on the survey data, the authors assessed the innovations and progress of the variety development special program.

Unlike other countries, most GM products in China are developed by public research institutes. There is rising concern on the ability of China’s public sector to continuously generate indigenous GM technology that can compete with multinational companies. The study surveyed 197 research institutes and 487 research teams and found that the GM program in China lacks coordination: researchers do not want to share their research materials with others. Due to the lack of coordination, most of the hundreds of research teams often worked independently in the year 2008-2010. Moreover, the authors found the lack of coordination may be due to the reason that the interests of researchers are not well protected. This paper also provided the recent progress and policy changes of GM program in China, and it found that the efficiency in the later three years improved a lot. In order to establish a competitive national public GM research system, China should continuously consolidate and integrate the upstream, midstream, and downstream activities of the whole GM innovation process. China’s public sector may also need to work more closely with both the domestic and international private sectors.

This paper is a comprehensive analysis on the development of transgenic technology in China. The results of this paper can provide evidence for the dynamic adjustment of the policies in the variety development special program and can also provide reference for the future assessment of the variety development special program.

Genetic engineering offers an opportunity to improve aspects of the agronomic performance, resistance to pests and pathogens and end use quality of crops by inserting specific genes. Discusses the basic principles and procedures of plant genetic engineering, including the use of particle bombardment for delivery of genes into regenerable tissues. Also discusses how this technology can be used to alter the level (up or down‐regulation) or pattern of expression of endogenous genes, or to insert novel activities or properties by inserting genes from other sources (other plants, animals or microbes). Finally, describes work in progress in our own laboratories on the improvement of the bread‐ making quality of wheat by manipulating the amount and composition of the HMW subunits of glutenin.

Gene term variation is a shortcoming in text‐mining applications based on biomedical literature‐based knowledge discovery. The purpose of this paper is to propose a technique for normalizing gene names in biomedical literature.

Under this proposal, the normalized forms can be characterized as a unique gene symbol, defined as the official symbol or normalized name. The unification method involves five stages: collection of the gene term, using the resources provided by the Entrez Gene database; encoding of gene‐naming terms in a table or binary matrix; design of a parametrized finite‐state graph (P‐FSG); automatic generation of a dictionary; and matching based on dictionary look‐up to transform the gene mentions into the corresponding unified form.

The findings show that the approach yields a high percentage of recall. Precision is only moderately high, basically due to ambiguity problems between gene‐naming terms and words and abbreviations in general English.

The major limitation of this study is that biomedical abstracts were analyzed instead of full‐text documents. The number of under‐normalization and over‐normalization errors is reduced considerably by limiting the realm of application to biomedical abstracts in a well‐defined domain.

The system can be used for practical tasks in biomedical literature mining. Normalized gene terms can be used as input to literature‐based gene clustering algorithms, for identifying hidden gene‐to‐disease, gene‐to‐gene and gene‐to‐literature relationships.

Few systems for gene term variation handling have been developed to date. The technique described performs gene name normalization by dictionary look‐up.

Globalization has affected science inevitably with a motto of ‘Knowledge conquers the mind’. However, global efforts and harmonization are needed and are established through international rules, laws, norms and standards. The potentially positive and negative results of globalization have altered the production relations and complicated the demographic scale.

Sociological studies of entrepreneurship focus on social and technical innovations in business. Using an illustration from molecular plant biology and the historical evolution of the term “entrepreneur,” I make a case for the theoretical and methodological importance of studying entrepreneurs and their ventures outside the scope of traditional business. Then, considering the scientific lab as a self-consciously entrepreneurial venture, I use the population of molecular biology labs studying the plant Arabidopsis thaliana to demonstrate a relationship less directly measurable among start-ups in business: diverse sources of funding accompany original activities and ideas within a venture. This is not, however, what predicts lab success. Lab size drives success, but hinders originality. Moreover, I show that established institutions in science are usually the ones that become innovations in business.

Purpose – The objective of this chapter is to examine and provide new perspectives on the contributions of public and private R&D to biotech crop improvement.

Methodology/approach – The chapter examines a set of topics that have affected the way that research is undertaken on plant germplasm improvement and how it has changed with the genetically modified (GM) trait revolution.

Findings – Although the basic science providing the foundations for GM crops was undertaken in the public sector, GM traits and GM crop varieties have been developed almost exclusively by the private sector. The biotech events leading to GM traits are currently being developed largely by five companies – all having ties to both the chemical and the seed industries. The GM crop revolution started in North American in 1996 and has spread slowly to the largest developing countries that have large agricultural sectors, including Argentina, China, Brazil, and India, but not to Europe or Japan.

Practical implication – To shed new light on the economic reasons for private sector dominance in GM crop varietal development in selected crops but not in others.

Social implication – Shows how GM traits have contributed to technical change and declining real food prices.

Considers the pre‐requisites for metabolic engineering (the redirection of enzymatic reactions to improve production or to mediate degradation of existing compounds and to promote production of new ones) in plants. Discusses recent successes in engineering increased production of beta‐carotene in a variety of food crops and suggests that the next stage for research development is in engineering complex metabolic pathways. Concludes that this will enhance humankind’s ability to turn plants into bio‐factories producing important compounds in a safe and sustainable manner.

This paper aims to depict the mechanistic role of vitamin D on dementia prevention, relief of the severity and the complication of the disease. All papers indexed in scientific databases, including Scopus, Elsevier, PubMed, Embase and Google Scholar between 2000 and 2021 were extracted and discussed. To present the mechanistic role of vitamin D in declining the severity of dementia, keywords including dementia, vitamin D, oxidative stress, inflammation, amyloid beta-Peptides were used.

Dementia is a prevalent cognitive disorder worldwide, especially in elderly people, which is accompanied by serious disabilities. Besides genetic, biological and lifestyle factors are involved in the incidence of dementia. An unhealthy diet along with micronutrient deficiencies are among modifiable factors. Vitamin D is one of the important micronutrients in brain health. Besides the involvement in gene expression, bone mineralization, apoptosis, inflammation, skeletal maturation, neurotropic action and hemostasis of phosphate and calcium, vitamin D also exerts neuroprotective effects via genomic and non-genomic pathways.

Vitamin D up-regulates the expression of various genes involved in dementia incidence via various mechanisms. Decreasing oxidative stress and the neuro-inflammatory cytokines levels, regulation of the expression of alternated Proteins including Tau and Amyloid-ß, calcium homeostasis in the central nervous system and also vascular are considered main mechanisms.

Considering the importance of diet in preventing dementia, adherence to a healthy diet that provides essential nutrients to brain function seems to be urgent. Controlling serum levels of vitamin D periodically and providing vitamin D by related sources or supplements, if there is a deficiency, is recommended. Future studies are needed to clarify other related mechanisms.

The purpose of this paper is to examine the potential of agri-biotech to play a role in meeting the world’s food, feed, fiber and fuel needs. Using case studies, policy developments in the key Asian countries of China, India and Japan are also scrutinized to determine the extent to which they enable or obstruct biotech’s potential.

The authors first examine some key challenges facing the agriculture and agri-food sector and the potential role biotech can play in addressing them. These challenges include feeding the world’s growing population, improving nutrition worldwide, dealing with allergen risks, reducing nutrient and chemical loading in watersheds, addressing water scarcity issues, and reducing waste in the food system. The authors then turn their attention to the agri-biotech systems in three Asian giants, including China’s centralized governance approach, India’s central-local policy and regulations, and Japan’s pragmatic and evidence-based regulatory framework.

Each nation has evolved its own system of governance based on the different challenges facing the society, the recognized potential of different biotech interventions, and citizens’ collective perceptions regarding both the potential and the risks that biotech innovations embody. Systems that are less evidence-based appear to be more discretionary and therefore are less predictable in their outcomes. This increases risks to prospective exporting firms and importing firms, driving up system costs and effectively serving as barriers to entry and to trade. It also dampens and distorts entrepreneurial and innovation incentives.

From the review and observations the authors then discuss ways and means of establishing priorities through a risk assessment framework in which key risks are enumerated and assessed in terms of their likelihoods and their conceivable consequences. Such an approach would allow challenges to be met with a degree of foresight and adaptability.

The sometimes disjointed, sometimes strategic use of biotech regulations have fragmented markets and created fiefdoms which undermine the potential of novel technologies to address the challenges facing society.

For illustrative purposes, the authors touch on land and water governance, regulatory and institutional bottlenecks and reforms and the potential for agri-biotech to play an elevated role if vested interests and obstructions can be overcome.

This study draws on research and literature from several disciplines. It also includes discussions relating to bureaucratic and administrative behavior which erodes the extent to which markets can be contested. This results in balkanized markets and non-cooperative behavior that undermines and distorts incentives for entrepreneurial effort and innovation. That such behavior takes place in markets and disciplines that are fundamental to assuring food security, nutrition and health, as well as good governance of scarce water and land resources is of considerable concern.