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1 – 3 of 3Neda Mahami, Nasim Abedimanesh, Somayyeh Asghari, Kosar Mohammadnejad, Mohammad Reza Eskandari, Zivar Nejadebrahimi, Hassan Ahangar, Keivan Nedaei, Mojtaba Fathi, Ehsan Noori and Behrooz Motlagh
This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis…
Abstract
Purpose
This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls.
Design/methodology/approach
PBMCs isolated from whole blood of 50 patients with CAD and 48 healthy subjects aged 45 to 60 years were treated with 10 and 20 µM of betanin for 24 h. Real-time polymerase chain reaction was performed to assess gene expression levels of AMPK, SIRT1 and SIRT6. The supernatants of the cultured cells were used to assess the IL-6 and TNF-α protein levels by ELISA.
Findings
Treatment with both doses of betanin significantly increased AMPK, SIRT1 and SIRT6 expression in PBMCs of CAD patients compared to control non-treated cells (p < 0.05). In PBMCs of healthy subjects, only treatment with high dose of betanin showed significant increase in AMPK (p = 0.007), SIRT1 (p = 0.013) and SIRT6 (p = 0.024) expression compared to control non-treated cells. Betanin (20 µM) also significantly decreased TNF-α and IL-6 concentrations in the culture supernatants of the CAD patients compared to control non-treated cells (p < 0.001).
Originality/value
Betanin could enhance AMPK, SIRT1 and SIRT6 gene expressions in PBMCs and represent a useful complementary treatment to reduce the proinflammatory status accompanied with CAD.
Ehsan Zia, Ebrahim Farshidi and Abdolnabi Kosarian
Pipelined analog-to-digital converters (ADCs) are widely used in electronic circuits. The purpose of this paper is to propose a new digital background calibration method to…
Abstract
Purpose
Pipelined analog-to-digital converters (ADCs) are widely used in electronic circuits. The purpose of this paper is to propose a new digital background calibration method to correct the capacitor mismatch, finite direct current (DC) gain and nonlinearity of residue amplifiers in pipelined ADCs.
Design/methodology/approach
The errors are corrected by defining new functions based on generalized Newton–Raphson algorithm. Although the functions have analytical solutions, an iterative procedure is used for calibration. To accelerate the calibration process, proper initialization for the errors is identified by using evaluation estimation block and solving inverse matrix.
Findings
Several behavioral simulations of a 12-bit 100MS/s pipelined ADC in MATLAB indicate that signal-to-(noise + distortion) ratio (SNDR) and spurious free dynamic range (SFDR) are improved from 30dB/33dB to 70dB/79dB after calibration. Calibration is achieved in approximately 2,000 clock cycles.
Practical implications
The digital part of the proposed method is implemented on field-programmable gate array to validate the performance of the pipelined ADC. The experimental result shows that the degradation of SNDR, SFDR, integral nonlinearity, differential nonlinearity and effective number of bits is negligible according to fixed-point operation vs floating-point in simulation results.
Originality/value
The novelty of this study is to use Newton–Raphson algorithm combined with appropriate initialization to reduce the number of divisions as well as calibration time, which is suitable in the recent nano-meter complementary metal oxide semiconductor technologies.
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The main aim of this study is to highlight the significance of fostering social capital and improving the quality of work life (QWL) for the well-being of healthcare workers. The…
Abstract
Purpose
The main aim of this study is to highlight the significance of fostering social capital and improving the quality of work life (QWL) for the well-being of healthcare workers. The second objective of this research is to address a notable gap in the current knowledge by examining the mediating influence of QWL on the relationship between work-related social capital and life satisfaction within the healthcare profession.
Design/methodology/approach
This study used a cross-sectional research methodology to examine the complex relationships among the variables and included a sample of 330 individuals who are employed full-time in the healthcare profession in the North Indian Region.
Findings
The study confirms all research hypotheses, showing that social capital improves work life. Thus, work-life quality improves life satisfaction significantly. The mediation analysis in this study used bootstrapping to show that work-life quality mediates the association between social capital and life satisfaction.
Practical implications
Addressing social support issues and using effective human resource management tactics can improve employees’ work life and satisfaction. The findings are essential in collectivistic cultures because strong workplace relationships improve professional welfare.
Originality/value
This study differentiates itself by analysing social capital and QWL as multi-dimensional constructs inside the workplace, ensuring the results’ correctness and validity. This study provides a distinct viewpoint for scholars and practitioners, enhancing comprehension of the correlation between life satisfaction and work-related social capital within the healthcare industry.
Details