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General Data Protection Regulation (GDPR) of the European Union (EU) was passed to protect data privacy. Though the GDPR intended to address issues related to data privacy in the EU, it created an extra-territorial effect through Articles 3, 45 and 46. Extra-territorial effect refers to the application or the effect of local laws and regulations in another country. Lawmakers around the globe passed or intensified their efforts to pass laws to have personal data privacy covered so that they meet the adequacy requirement under Articles 45–46 of GDPR while providing comprehensive legislation locally. This study aims to analyze the Malaysian and Saudi Arabian legislation on health data privacy and their adequacy in meeting GDPR data privacy protection requirements.

The research used a systematic literature review, legal content analysis and comparative analysis to critically analyze the health data protection in Malaysia and Saudi Arabia in comparison with GDPR and to see the adequacy of health data protection that could meet the requirement of EU data transfer requirement.

The finding suggested that the private sector is better regulated in Malaysia than the public sector. Saudi Arabia has some general laws to cover health data privacy in both public and private sector organizations until the newly passed data protection law is implemented in 2024. The finding also suggested that the Personal Data Protection Act 2010 of Malaysia and the Personal Data Protection Law 2022 of Saudi Arabia could be considered “adequate” under GDPR.

The research would be able to identify the key principles that could identify the adequacy of the laws about health data in Malaysia and Saudi Arabia as there is a dearth of literature in this area. This will help to propose suggestions to improve the laws concerning health data protection so that various stakeholders can benefit from it.

Digital healthcare once again emerges due to pandemic (Covid-19). Digital healthcare can be minimising the issue of accessibility, availability, accuracy and affordability of healthcare service during a pandemic. Digital healthcare playsa significant role to provide healthcare equity during the pandemic. This article presents the current trends and scenario of digital healthcare with a focus on health equity. The main objective of this chapter is to review the four aces of health equity in the digital healthcare literature. The scope and challenges faced by the policymakers to implementation of digital healthcare to improve health equity. This chapter considers the hybrid literature review based on the bibliometric and the systematic literature based on the various theme, sub-theme, concept and context-related health equity through digital healthcare. This study provides the previous and current research trends and preposition for the future researcher, healthcare professional, policymakers and digital healthcare innovators to invent the tool which leads the health equity through the digital healthcare in the healthcare.

The purpose of the study is to classify the radiographic images into three categories such as fillings, cavity and implant to identify dental diseases because dental disease is a very common dental health problem for all people. The detection of dental issues and the selection of the most suitable method of treatment are both determined by the results of a radiological examination. Dental x-rays provide important information about the insides of teeth and their surrounding cells, which helps dentists detect dental issues that are not immediately visible. The analysis of dental x-rays, which is typically done by dentists, is a time-consuming process that can become an error-prone technique due to the wide variations in the structure of teeth and the dentist's lack of expertise. The workload of a dental professional and the chance of misinterpretation can be decreased by the availability of such a system, which can interpret the result of an x-ray automatically.

This study uses deep learning (DL) models to identify dental diseases in order to tackle this issue. Four different DL models, such as ResNet-101, Xception, DenseNet-201 and EfficientNet-B0, were evaluated in order to determine which one would be the most useful for the detection of dental diseases (such as fillings, cavity and implant).

Loss and accuracy curves have been used to analyze the model. However, the EfficientNet-B0 model performed better compared to Xception, DenseNet-201 and ResNet-101. The accuracy, recall, F1-score and AUC values for this model were 98.91, 98.91, 98.74 and 99.98%, respectively. The accuracy rates for the Xception, ResNet-101 and DenseNet-201 are 96.74, 93.48 and 95.65%, respectively.

The present study can benefit dentists from using the DL model to more accurately diagnose dental problems.

This study is conducted to evaluate dental diseases using Convolutional neural network (CNN) techniques to assist dentists in selecting the most effective technique for a particular clinical condition.

This study specifically seeks to investigate the strategic implementation of machine learning (ML) algorithms and techniques in healthcare institutions to enhance innovation management in healthcare settings.

The papers from 2011 to 2021 were considered following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. First, relevant keywords were identified, and screening was performed. Bibliometric analysis was performed. One hundred twenty-three relevant documents that passed the eligibility criteria were finalized.

Overall, the annual scientific production section results reveal that ML in the healthcare sector is growing significantly. Performing bibliometric analysis has helped find unexplored areas; understand the trend of scientific publication; and categorize topics based on emerging, trending and essential. The paper discovers the influential authors, sources, countries and ML and healthcare management keywords.

The study helps understand various applications of ML in healthcare institutions, such as the use of Internet of Things in healthcare, the prediction of disease, finding the seriousness of a case, natural language processing, speech and language-based classification, etc. This analysis would help future researchers and developers target the healthcare sector areas that are likely to grow in the coming future.

The study highlights the potential for ML to enhance medical support within healthcare institutions. It suggests that regression algorithms are particularly promising for this purpose. Hospital management can leverage time series ML algorithms to estimate the number of incoming patients, thus increasing hospital availability and optimizing resource allocation. ML has been instrumental in the development of these systems. By embracing telemedicine and remote monitoring, healthcare management can facilitate the creation of online patient surveillance and monitoring systems, allowing for early medical intervention and ultimately improving the efficiency and effectiveness of medical services.

By offering a comprehensive panorama of ML's integration within healthcare institutions, this study underscores the pivotal role of innovation management in healthcare. The findings contribute to a holistic understanding of ML's applications in healthcare and emphasize their potential to transform and optimize healthcare delivery.

The purpose of this study is to examine the state of research into adoption of machine learning systems within the health sector, to identify themes that have been studied and observe the important gaps in the literature that can inform a research agenda going forward.

A systematic literature strategy was utilized to identify and analyze scientific papers between 2012 and 2022. A total of 28 articles were identified and reviewed.

The outcomes reveal that while advances in machine learning have the potential to improve service access and delivery, there have been sporadic growth of literature in this area which is perhaps surprising given the immense potential of machine learning within the health sector. The findings further reveal that themes such as recordkeeping, drugs development and streamlining of treatment have primarily been focused on by the majority of authors in this area.

The search was limited to journal articles published in English, resulting in the exclusion of studies disseminated through alternative channels, such as conferences, and those published in languages other than English. Considering that scholars in developing nations may encounter less difficulty in disseminating their work through alternative channels and that numerous emerging nations employ languages other than English, it is plausible that certain research has been overlooked in the present investigation.

This review provides insights into future research avenues for theory, content and context on adoption of machine learning within the health sector.

Renal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.

Experimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.

The following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.

SAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.

The purpose of this paper is to develop a software-library in the R programming language that implements the concepts of the interpretive coordinate, interpretive axis and interpretive plane. This allows for the automatic and reliable interpretation of results from the multiple correspondence analysis (MCA) as previously proposed and published. Consequently, the users can seamlessly apply these concepts to their data, both via R commands and a corresponding graphical interface.

Within the context of this study, and through extensive literature review, the advantages of developing software using the Shiny library were examined. This library allows for the development of full-stack applications for R users without the need for knowledge of the corresponding technologies required for the development of complex applications. Additionally, the structural components of a Shiny application were presented, leading ultimately to the proposed software application.

Software utilizing the Shiny library enables nonexpert developers to rapidly develop specialized applications, either to present or to assist in the understanding of objects or concepts that are scientifically intriguing and complex. Specifically, with this proposed application, the users can promptly and effectively apply the scientific concepts addressed in this study to their data. Additionally, they can dynamically generate charts and reports that are readily available for download and sharing.

The proposed package is an implementation of the fundamental concepts of the exploratory MCA method. In the next step, discoveries from the geometric data analysis will be added as features to provide more comprehensive information to the users.

The practical implications of this work include the dissemination of the method’s use to a broader audience. Additionally, the decision to implement it with open-source code will result in the integration of the package’s functions by other third-party user packages.

The proposed software introduces the initial implementation of concepts such as interpretive coordination, the interpretive axis and the interpretive plane. This package aims to broaden and simplify the application of these concepts to benefit stakeholders in scientific research. The software can be accessed for free in a code repository, the link to which is provided in the full text of the study.

The purpose of this study is to develop a domain independent, cost-effective, time-saving and semi-automated ontology generation framework that could extract taxonomic concepts from unstructured text corpus. In the human disease domain, ontologies are found to be extremely useful for managing the diversity of technical expressions in favour of information retrieval objectives. The boundaries of these domains are expanding so fast that it is essential to continuously develop new ontologies or upgrade available ones.

This paper proposes a semi-automated approach that extracts entities/relations via text mining of scientific publications. Text mining-based ontology (TmbOnt)-named code is generated to assist a user in capturing, processing and establishing ontology elements. This code takes a pile of unstructured text files as input and projects them into high-valued entities or relations as output. As a semi-automated approach, a user supervises the process, filters meaningful predecessor/successor phrases and finalizes the demanded ontology-taxonomy. To verify the practical capabilities of the scheme, a case study was performed to drive glaucoma ontology-taxonomy. For this purpose, text files containing 10,000 records were collected from PubMed.

The proposed approach processed over 3.8 million tokenized terms of those records and yielded the resultant glaucoma ontology-taxonomy. Compared with two famous disease ontologies, TmbOnt-driven taxonomy demonstrated a 60%–100% coverage ratio against famous medical thesauruses and ontology taxonomies, such as Human Disease Ontology, Medical Subject Headings and National Cancer Institute Thesaurus, with an average of 70% additional terms recommended for ontology development.

According to the literature, the proposed scheme demonstrated novel capability in expanding the ontology-taxonomy structure with a semi-automated text mining approach, aiming for future fully-automated approaches.

Deep learning (DL) is on the rise because it can make predictions and judgments based on data that is unseen. Blockchain technologies are being combined with DL frameworks in various industries to provide a safe and effective infrastructure. The review comprises literature that lists the most recent techniques used in the aforementioned application sectors. We examine the current research trends across several fields and evaluate the literature in terms of its advantages and disadvantages.

The integration of blockchain and DL has been explored in several application domains for the past five years (2018–2023). Our research is guided by five research questions, and based on these questions, we concentrate on key application domains such as the usage of Internet of Things (IoT) in several applications, healthcare and cryptocurrency price prediction. We have analyzed the main challenges and possibilities concerning blockchain technologies. We have discussed the methodologies used in the pertinent publications in these areas and contrasted the research trends during the previous five years. Additionally, we provide a comparison of the widely used blockchain frameworks that are used to create blockchain-based DL frameworks.

By responding to five research objectives, the study highlights and assesses the effectiveness of already published works using blockchain and DL. Our findings indicate that IoT applications, such as their use in smart cities and cars, healthcare and cryptocurrency, are the key areas of research. The primary focus of current research is the enhancement of existing systems, with data analysis, storage and sharing via decentralized systems being the main motivation for this integration. Amongst the various frameworks employed, Ethereum and Hyperledger are popular among researchers in the domain of IoT and healthcare, whereas Bitcoin is popular for research on cryptocurrency.

There is a lack of literature that summarizes the state-of-the-art methods incorporating blockchain and DL in popular domains such as healthcare, IoT and cryptocurrency price prediction. We analyze the existing research done in the past five years (2018–2023) to review the issues and emerging trends.